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Exosomes and MicroRNAs in Biomedical Science

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Exosomes and MicroRNAs in Biomedical Science/ by Hamed Mirzaei, Neda Rahimian, Hamid Reza Mirzaei, Javid Sadri Nahand, Michael R. Hamblin.
作者:	Mirzaei, Hamed.
其他作者:	Hamblin, Michael R.
面頁冊數:	IV, 175 p.online resource. :
Contained By:	Springer Nature eBook
標題:	Biomedical Engineering and Bioengineering. -
電子資源:	https://doi.org/10.1007/978-3-031-79177-2
ISBN:	9783031791772

Exosomes and MicroRNAs in Biomedical Science
Mirzaei, Hamed.

Exosomes and MicroRNAs in Biomedical Science[electronic resource] /by Hamed Mirzaei, Neda Rahimian, Hamid Reza Mirzaei, Javid Sadri Nahand, Michael R. Hamblin. - 1st ed. 2022. - IV, 175 p.online resource. - Synthesis Lectures on Biomedical Engineering,1930-0336. - Synthesis Lectures on Biomedical Engineering,.

MicroRNAs (miRNAs) are a member of the family of non-coding RNA molecules, and consist of small conserved sequences between 19–25 nucleotides in length that are responsible for regulating many cellular functions by affecting a wide range of messenger RNAs in a sequence specific manner. Fundamental biological processes like cell proliferation and growth, stress resistance, tumorigenesis, fat metabolism, and neural development have all been shown to be governed by miRNAs. miRNAs carry out the post-transcriptional silencing of gene expression via targeting the 30-untranslated region (UTR) of the complementary mRNA sequence. The dysregulation of the expression levels of various miRNAs is typical of tumor cells, and has been associated with tumor progression and poor prognosis. Many miRNAs are up-regulated in cancer, where they can silence tumor suppressor genes such as apoptosis and immune response associated genes. Therefore, it is possible to profile the expression levels of miRNAs as biomarkers, in order to diagnose cancer and noncancerous diseases. Moreover, cancer detection in the early stages is crucial in clinical situations. Characterization of miRNAs in serum, plasma, and other bodily fluids, and understanding their stability against RNase degradation, is important to assess their suitability as biomarkers and diagnostic tools. Exosomes play an important role in inter-cellular communications, and these nanosized particles have various functions in diverse physiological pathways, in normal as well as abnormal cells. Exosomes can carry diverse cargos such as mRNAs, miRNAs, and proteins that transfer information between donor and recipient cells. Furthermore, uptake of exosomes and their cargos may promote or suppress various molecular and cellular pathways, which alter the cellular behavior. Many reports have discussed the role of exosomes released from cancer cells on the progression of cancer at various stages. Exosomes and their cargos may affect the growth of the tumor, metastasis, drug resistance, immune system function, as well as angiogenesis. Therefore, exosomes have been explored as diagnostic biomarkers in many cancers. Moreover, exosomes can be used as biological vehicles to deliver different drugs and agents like doxorubicin (DOX), miRNAs, and siRNAs. The present book covers the role of exosomes and micro-RNAs in the pathogenesis and treatment of various diseases.

ISBN: 9783031791772

Standard No.: 10.1007/978-3-031-79177-2doiSubjects--Topical Terms:

1211019
Biomedical Engineering and Bioengineering.

LC Class. No.: T1-995

Dewey Class. No.: 620

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