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From Obesity to Diabetes

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	From Obesity to Diabetes/ edited by Juergen Eckel, Karine Clément.
其他作者:	Clément, Karine.
面頁冊數:	VIII, 513 p. 1 illus.online resource. :
Contained By:	Springer Nature eBook
標題:	Metabolic Disease. -
電子資源:	https://doi.org/10.1007/978-3-030-99995-7
ISBN:	9783030999957

From Obesity to Diabetes
From Obesity to Diabetes[electronic resource] /edited by Juergen Eckel, Karine Clément. - 1st ed. 2022. - VIII, 513 p. 1 illus.online resource. - Handbook of Experimental Pharmacology,2741865-0325 ;. - Handbook of Experimental Pharmacology,224.

Part I Obesity. Epidemiology of Obesity -- The Circadian Clock and Obesity -- Nutrition and Microbiome -- From Obesity to Diabetes: The Role of the Adipose Organ -- Targeting Epicardial Fat in Obesity and Diabetes Pharmacotherapy -- The Enteroendocrine System in Obesity -- Insights from Studies of White Adipose Tissue Using Single-Cell Approaches -- Obesity-Related Insulin Resistance: The Central Role of Adipose Tissue Dysfunction -- Obesity, Senescence, and Senolytics -- Obesity and Obstructive Sleep Apnea -- Part II Diabetes and Complications. Inter-Organ Crosstalk in the Development of Obesity-Associated Insulin Resistance -- Islet Inflammation and β Cell Dysfunction in Type 2 Diabetes -- NAFLD and NASH: The Metabolically Diseased Liver -- Diabetic Kidney Disease: From Pathogenesis to Novel Treatment Possibilities -- Diabetic Peripheral Neuropathy -- Part III Lifestyle Modifications and Future Treatments. Weight Loss Strategies -- Physical Activity, Obesity and Weight Loss Maintenance -- Bariatric/Metabolic Surgery -- Drugs for Treating Obesity -- Novel Drugs for Diabetes Therapy -- Novel Approaches to Restore Pancreatic Beta-Cell Mass and Function -- Precision Medicine and Obesity -- Targeting the Enteroendocrine System for Treatment of Obesity.

Obesity is a major risk factor for the development of type 2 diabetes and its associated complications, a major socio-economic burden for health care systems. The worldwide prevalence of obesity doubled since 1980 and as a consequence the number of patients with diabetes has been continuously rising with more than 450 Mio. people suffering from this disease at the present time. Substantial progress has been made in understanding the molecular pathways leading from excessive fat accumulation to metabolic perturbation and finally diabetes manifestation. This edition of the "Handbook of Experimental Pharmacology" aims to analyze new insight into the pathophysiology of obesity, to decipher the complex links to diabetes and its complications, and to collect most recent information on new strategies for prevention and treatment of obesity and diabetes.

ISBN: 9783030999957

Standard No.: 10.1007/978-3-030-99995-7doiSubjects--Topical Terms:

1393722
Metabolic Disease.

LC Class. No.: RM300-666

Dewey Class. No.: 615

From Obesity to Diabetes
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