國立虎尾科技大學 |

Tuning Autophagy-Inducing Activity and Toxicity for Lanthanide Nanocrystals

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Tuning Autophagy-Inducing Activity and Toxicity for Lanthanide Nanocrystals/ by Yunjiao Zhang.
作者:	Zhang, Yunjiao.
面頁冊數:	XV, 156 p. 78 illus., 66 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Biomedical Research. -
電子資源:	https://doi.org/10.1007/978-981-16-8166-0
ISBN:	9789811681660

Tuning Autophagy-Inducing Activity and Toxicity for Lanthanide Nanocrystals
Zhang, Yunjiao.

Tuning Autophagy-Inducing Activity and Toxicity for Lanthanide Nanocrystals[electronic resource] /by Yunjiao Zhang. - 1st ed. 2022. - XV, 156 p. 78 illus., 66 illus. in color.online resource. - Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5061. - Springer Theses, Recognizing Outstanding Ph.D. Research,.

Introduction -- Phage display identifies a specific high-affinity binding peptide RE-1 for lanthanide (LN) nanomaterials -- RE-1 forms a stable coating layer on the surface of upconversion nanoparticles / nanocrystals (UCN) -- Reduction of UCN sedimentation and nanomaterial–cell interaction by RE-1 coating -- RE-1 coating abrogates autophagy induction and toxicity for UCN in vitro and in vivo -- Enhancement of cell interaction and autophagy induction by coating with RE-1-RGD.-Conclusion and prospect.

This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.

ISBN: 9789811681660

Standard No.: 10.1007/978-981-16-8166-0doiSubjects--Topical Terms:

643481
Biomedical Research.

LC Class. No.: T174.7

Dewey Class. No.: 620.5

Tuning Autophagy-Inducing Activity and Toxicity for Lanthanide Nanocrystals
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