國立虎尾科技大學 |

Chemical Biology = and Drug Discovery /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Chemical Biology/ by Marco F. Schmidt.
其他題名:	and Drug Discovery /
作者:	Schmidt, Marco F.
面頁冊數:	IX, 223 p. 140 illus., 100 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Biomedical Research. -
電子資源:	https://doi.org/10.1007/978-3-662-64412-6
ISBN:	9783662644126

Chemical Biology = and Drug Discovery /
Schmidt, Marco F.

Chemical Biologyand Drug Discovery /[electronic resource] :by Marco F. Schmidt. - 1st ed. 2022. - IX, 223 p. 140 illus., 100 illus. in color.online resource.

Foreword -- Introduction -- Part I: Chemical Biology and Drug Development -- Chemical Biology - a Holistic Science -- Drug Development -- From Genomics to Chemical Biology -- Part II: DNA -- DNA - blueprint of proteins -- Genomic Variation -- Gene Therapy and Genome Editing -- Part III: RNA -- RNA - information and function carrier -- RNA Interference in Drug Development -- Part IV: Proteins -- Peptides & proteins -- Proteins as drug targets -- Chemical genomics - From target protein to drug -- From target protein to macromolecular drug - Biologics -- Chemical proteomics: From drug to target protein -- Chemical genetics: validation of drug target by elucidation of signaling pathway -- Chemical biology - Addressing new drug targets.

The focus of this textbook is on application, rather than pure knowledge transfer of the results of all chemical biological work (which would also be beyond the scope of a book). It gives the reader, through the specific selection of chemical-biological techniques and concepts, the necessary tools to be able to develop new ways of thinking and thus new therapeutic options in the complex field of chemical biology and drug development. The stated aim of this book is to provide concrete solutions and inspiration to students, (post)graduate students, and experienced scientists at universities as well as in industry in their problems. After an introduction to the problems addressed by chemical biology in drug discovery, the three levels of molecular biology dogma: DNA, RNA and proteins and their role as drug targets serve as the common thread of this book. This book is a translation of the original German 1st edition Chemische Biologie by Marco F. Schmidt, published by Springer-Verlag GmbH Germany, part of Springer Nature in 2020. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors. Marco F. Schmidt is co-founder and Chief Scientific Officer of biotx.ai Inc. which develops Artificial Intelligence for biomedical data analysis. Together with his team, he researches how machine learning can be used to identify drug targets and predict the clinical effect of drug candidates. He studied biochemistry at the FU Berlin and in Tübingen, received his PhD in chemical biology at the FMP Berlin and worked on new drug concepts at the University of Cambridge.

ISBN: 9783662644126

Standard No.: 10.1007/978-3-662-64412-6doiSubjects--Topical Terms:

643481
Biomedical Research.

LC Class. No.: QP550-801

Dewey Class. No.: 547

Chemical Biology = and Drug Discovery /
LDR:04070nam a22004215i 4500 001 1093740
003 DE-He213
005 20220131213213.0
007 cr nn 008mamaa
008 221228s2022 gw | s |||| 0|eng d
020 $a 9783662644126 $9 978-3-662-64412-6
024 7 $a 10.1007/978-3-662-64412-6 $2 doi
035 $a 978-3-662-64412-6
050 4 $a QP550-801
072 7 $a PNN $2 bicssc
072 7 $a PSB $2 bicssc
072 7 $a SCI013040 $2 bisacsh
072 7 $a PNN $2 thema
072 7 $a PSB $2 thema
082 0 4 $a 547 $2 23
082 0 4 $a 572 $2 23
100 1 $a Schmidt, Marco F. $e author. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 1317539
245 1 0 $a Chemical Biology $h [electronic resource] : $b and Drug Discovery / $c by Marco F. Schmidt.
250 $a 1st ed. 2022.
264 1 $a Berlin, Heidelberg : $b Springer Berlin Heidelberg : $b Imprint: Springer, $c 2022.
300 $a IX, 223 p. 140 illus., 100 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
505 0 $a Foreword -- Introduction -- Part I: Chemical Biology and Drug Development -- Chemical Biology - a Holistic Science -- Drug Development -- From Genomics to Chemical Biology -- Part II: DNA -- DNA - blueprint of proteins -- Genomic Variation -- Gene Therapy and Genome Editing -- Part III: RNA -- RNA - information and function carrier -- RNA Interference in Drug Development -- Part IV: Proteins -- Peptides & proteins -- Proteins as drug targets -- Chemical genomics - From target protein to drug -- From target protein to macromolecular drug - Biologics -- Chemical proteomics: From drug to target protein -- Chemical genetics: validation of drug target by elucidation of signaling pathway -- Chemical biology - Addressing new drug targets.
520 $a The focus of this textbook is on application, rather than pure knowledge transfer of the results of all chemical biological work (which would also be beyond the scope of a book). It gives the reader, through the specific selection of chemical-biological techniques and concepts, the necessary tools to be able to develop new ways of thinking and thus new therapeutic options in the complex field of chemical biology and drug development. The stated aim of this book is to provide concrete solutions and inspiration to students, (post)graduate students, and experienced scientists at universities as well as in industry in their problems. After an introduction to the problems addressed by chemical biology in drug discovery, the three levels of molecular biology dogma: DNA, RNA and proteins and their role as drug targets serve as the common thread of this book. This book is a translation of the original German 1st edition Chemische Biologie by Marco F. Schmidt, published by Springer-Verlag GmbH Germany, part of Springer Nature in 2020. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors. Marco F. Schmidt is co-founder and Chief Scientific Officer of biotx.ai Inc. which develops Artificial Intelligence for biomedical data analysis. Together with his team, he researches how machine learning can be used to identify drug targets and predict the clinical effect of drug candidates. He studied biochemistry at the FU Berlin and in Tübingen, received his PhD in chemical biology at the FMP Berlin and worked on new drug concepts at the University of Cambridge.
650 2 4 $a Biomedical Research. $3 643481
650 2 4 $a Medicinal Chemistry. $3 668872
650 2 4 $a Medical Biochemistry. $3 668897
650 2 4 $a Life Sciences. $3 593888
650 1 4 $a Bioorganic Chemistry. $3 677511
650 0 $a Pharmacy. $3 582411
650 0 $a Biology—Research. $3 1365799
650 0 $a Medicine—Research. $3 1365798
650 0 $a Medicinal chemistry. $3 1253747
650 0 $a Clinical biochemistry. $3 591508
650 0 $a Life sciences. $3 815602
650 0 $a Bioorganic chemistry. $3 743635
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9783662644119
776 0 8 $i Printed edition: $z 9783662644133
856 4 0 $u https://doi.org/10.1007/978-3-662-64412-6
912 $a ZDB-2-CMS
912 $a ZDB-2-SXC
950 $a Chemistry and Materials Science (SpringerNature-11644)
950 $a Chemistry and Material Science (R0) (SpringerNature-43709)