國立虎尾科技大學 |

New Model-Based and Deep Learning Methods for Survival Data with or Without Competing Risks.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	New Model-Based and Deep Learning Methods for Survival Data with or Without Competing Risks./
Author:	Jia, Yichen.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2022,
Description:	93 p.
Notes:	Source: Dissertations Abstracts International, Volume: 84-03, Section: B.
Contained By:	Dissertations Abstracts International84-03B.
Subject:	Probability. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29281169
ISBN:	9798845433183

New Model-Based and Deep Learning Methods for Survival Data with or Without Competing Risks.
Jia, Yichen.

New Model-Based and Deep Learning Methods for Survival Data with or Without Competing Risks. - Ann Arbor : ProQuest Dissertations & Theses, 2022 - 93 p.

Source: Dissertations Abstracts International, Volume: 84-03, Section: B.

Thesis (Ph.D.)--University of Pittsburgh, 2022.

This item must not be sold to any third party vendors.

Survival data (or time-to-event data) is a special type of data that focus on the time until occurrence of an event of interest. Traditional statistical methods have been based on the survival function or hazard function. This dissertation proposes inference and prediction models for survival data that focus on event time itself and its various quantities.In the first part, a quantile regression model is proposed to associate the inactivity time, a new summary measure for survival data, with covariates under competing risks. Asymptotic properties were derived for the regression coefficient estimators and associated test statistics. Simulation results show that my proposed method works well under the assumed finite sample settings. The proposed method is then illustrated with a real dataset from a breast cancer study.In the second part, a deep learning method for quantile regression, DeepQuantreg, is developed to predict conditional quantile survival time. The Huber check function was adopted in the loss function with inverse probability weights to adjust for censoring. Sim- ulation studies were performed to generate nonlinear censored survival data and compare the deep learning method with the traditional linear quantile regression and nonparametric quantile regression. The proposed method is illustrated with two publicly available breast cancer data sets with gene signatures.In the third part, a deep learning method with an innovative loss function, DeepCENT, is proposed to directly predict survival time. The newly proposed loss function combines the mean square error and the concordance index, which not only consider the prediction accu- racy but also the discriminative performance. Moreover, DeepCENT can handle competing risks. The validity and advantage of DeepCENT were evaluated using simulation studies and illustrated with three publicly available cancer data sets.

ISBN: 9798845433183Subjects--Topical Terms:

667790
Probability.

New Model-Based and Deep Learning Methods for Survival Data with or Without Competing Risks.
LDR:03101nam a2200373 4500 001 1104647
005 20230619080111.5
006 m o d
007 cr#unu||||||||
008 230907s2022 ||||||||||||||||| ||eng d
020 $a 9798845433183
035 $a (MiAaPQ)AAI29281169
035 $a (MiAaPQ)Pittsburgh42575
035 $a AAI29281169
040 $a MiAaPQ $c MiAaPQ
100 1 $a Jia, Yichen. $3 1413552
245 1 0 $a New Model-Based and Deep Learning Methods for Survival Data with or Without Competing Risks.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2022
300 $a 93 p.
500 $a Source: Dissertations Abstracts International, Volume: 84-03, Section: B.
500 $a Advisor: Ding, Ying;Cheng, Yu;Chang, Chung-Chou H. ;Jeong, Jong H. .
502 $a Thesis (Ph.D.)--University of Pittsburgh, 2022.
506 $a This item must not be sold to any third party vendors.
520 $a Survival data (or time-to-event data) is a special type of data that focus on the time until occurrence of an event of interest. Traditional statistical methods have been based on the survival function or hazard function. This dissertation proposes inference and prediction models for survival data that focus on event time itself and its various quantities.In the first part, a quantile regression model is proposed to associate the inactivity time, a new summary measure for survival data, with covariates under competing risks. Asymptotic properties were derived for the regression coefficient estimators and associated test statistics. Simulation results show that my proposed method works well under the assumed finite sample settings. The proposed method is then illustrated with a real dataset from a breast cancer study.In the second part, a deep learning method for quantile regression, DeepQuantreg, is developed to predict conditional quantile survival time. The Huber check function was adopted in the loss function with inverse probability weights to adjust for censoring. Sim- ulation studies were performed to generate nonlinear censored survival data and compare the deep learning method with the traditional linear quantile regression and nonparametric quantile regression. The proposed method is illustrated with two publicly available breast cancer data sets with gene signatures.In the third part, a deep learning method with an innovative loss function, DeepCENT, is proposed to directly predict survival time. The newly proposed loss function combines the mean square error and the concordance index, which not only consider the prediction accu- racy but also the discriminative performance. Moreover, DeepCENT can handle competing risks. The validity and advantage of DeepCENT were evaluated using simulation studies and illustrated with three publicly available cancer data sets.
590 $a School code: 0178.
650 4 $a Probability. $3 667790
650 4 $a Gene expression. $3 581931
650 4 $a Deep learning. $3 1127428
650 4 $a Survival analysis. $3 1413553
650 4 $a Breast cancer. $3 1413554
650 4 $a Neural networks. $3 1011215
650 4 $a Bioinformatics. $3 583857
650 4 $a Genetics. $3 578972
650 4 $a Mathematics. $3 527692
650 4 $a Oncology. $3 593951
690 $a 0800
690 $a 0715
690 $a 0369
690 $a 0405
690 $a 0992
710 2 $a University of Pittsburgh. $3 1178873
773 0 $t Dissertations Abstracts International $g 84-03B.
790 $a 0178
791 $a Ph.D.
792 $a 2022
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29281169