國立虎尾科技大學 |

Microfluidic Generation of Polymeric Microparticle Droplets.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Microfluidic Generation of Polymeric Microparticle Droplets./
作者:	Hanan, Blake F.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2022,
面頁冊數:	57 p.
附註:	Source: Masters Abstracts International, Volume: 84-05.
Contained By:	Masters Abstracts International84-05.
標題:	Biomedical engineering. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30192769
ISBN:	9798352946824

Microfluidic Generation of Polymeric Microparticle Droplets.
Hanan, Blake F.

Microfluidic Generation of Polymeric Microparticle Droplets. - Ann Arbor : ProQuest Dissertations & Theses, 2022 - 57 p.

Source: Masters Abstracts International, Volume: 84-05.

Thesis (M.S.)--Vanderbilt University, 2022.

This item must not be sold to any third party vendors.

Long-term, sustained drug release utilizing an injectable delivery vehicle in localized, chronic diseases is a therapeutic strategy with the potential to extend the action of drugs, reduce drug off-target side effects, and improve patient compliance/outcomes. Polymeric microparticles (MPs) are one such delivery strategy in which drugs are encapsulated and immobilized in a polymer matrix. Bulk emulsion methods of generating MPs, in which a solubilized polymer is added to a separate, immiscible phase, forming droplets that harden into particles when the solvent is removed, often results in high polydispersity and low drug loading efficiency. To address these issues, droplet microfluidics was employed to produce monodisperse polymeric microparticles. Traditional microfluidic devices are made of an elastomeric polymer, polydimethylsiloxane (PDMS), however many solvents required to solubilize more intelligently responsive polymers are incompatible with this material. Therefore, we developed a high-fidelity glass etching method to microfabricate devices compatible with a variety of solvents, allowing for the generation of MPs with improved quality metrics using polymers of varying crystallinities and solubilities, including the clinical standard poly(lactic-co-glycolic acid) (PLGA), as well as antioxidant scavenging polysulfide polymers.

ISBN: 9798352946824Subjects--Topical Terms:

588770
Biomedical engineering.
Subjects--Index Terms:

Glass microfluidics

Microfluidic Generation of Polymeric Microparticle Droplets.
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300 $a 57 p.
500 $a Source: Masters Abstracts International, Volume: 84-05.
500 $a Advisor: Duvall, Craig.
502 $a Thesis (M.S.)--Vanderbilt University, 2022.
506 $a This item must not be sold to any third party vendors.
520 $a Long-term, sustained drug release utilizing an injectable delivery vehicle in localized, chronic diseases is a therapeutic strategy with the potential to extend the action of drugs, reduce drug off-target side effects, and improve patient compliance/outcomes. Polymeric microparticles (MPs) are one such delivery strategy in which drugs are encapsulated and immobilized in a polymer matrix. Bulk emulsion methods of generating MPs, in which a solubilized polymer is added to a separate, immiscible phase, forming droplets that harden into particles when the solvent is removed, often results in high polydispersity and low drug loading efficiency. To address these issues, droplet microfluidics was employed to produce monodisperse polymeric microparticles. Traditional microfluidic devices are made of an elastomeric polymer, polydimethylsiloxane (PDMS), however many solvents required to solubilize more intelligently responsive polymers are incompatible with this material. Therefore, we developed a high-fidelity glass etching method to microfabricate devices compatible with a variety of solvents, allowing for the generation of MPs with improved quality metrics using polymers of varying crystallinities and solubilities, including the clinical standard poly(lactic-co-glycolic acid) (PLGA), as well as antioxidant scavenging polysulfide polymers.
590 $a School code: 0242.
650 4 $a Biomedical engineering. $3 588770
653 $a Glass microfluidics
653 $a Droplet microfluidics
653 $a Glass etching
653 $a PLGA
653 $a Microparticles
653 $a Microfabrication
653 $a Polysulfide
653 $a Drug delivery
653 $a Polymeric microparticles
653 $a Emulsions
690 $a 0541
710 2 $a Vanderbilt University. $3 1178871
773 0 $t Masters Abstracts International $g 84-05.
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793 $a English
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