國立虎尾科技大學 |

Bioprocess and analytics development for virus-based advanced therapeutics and medicinal products (ATMPs)

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Bioprocess and analytics development for virus-based advanced therapeutics and medicinal products (ATMPs)/ edited by Saurabh Gautam, Abhilash I. Chiramel, Roland Pach.
其他作者:	Pach, Roland.
出版者:	Cham :Springer International Publishing : : 2023.,
面頁冊數:	xvi, 442 p. :ill. (some col.), digital ; : 24 cm.;
Contained By:	Springer Nature eBook
標題:	Therapeutics. -
電子資源:	https://doi.org/10.1007/978-3-031-28489-2
ISBN:	9783031284892

Bioprocess and analytics development for virus-based advanced therapeutics and medicinal products (ATMPs)
Bioprocess and analytics development for virus-based advanced therapeutics and medicinal products (ATMPs)[electronic resource] /edited by Saurabh Gautam, Abhilash I. Chiramel, Roland Pach. - Cham :Springer International Publishing :2023. - xvi, 442 p. :ill. (some col.), digital ;24 cm.

Chapter 1: Bioprocessing and analytical development for virus-based therapeutics -- Chapter 2: Viral Vector Upstream Processing and Clarification -- Chapter 3: Upstream processing of viral therapeutics: From host cell expansion to virus production -- Chapter 4: Leveraging virus biology and host genetic conflicts for cell line development and engineering for virus-based therapeutics -- Chapter 5: Overview of Current Downstream Processing for Modern Viral Vectors -- Chapter 6: Filtration Principles and Techniques for Bioprocessing of Viral Vector-Based Therapeutics -- Chapter 7: Chromatographic purification of viruses: State of the art and current trends -- Chapter 8: Purifying Viral Vectors - A Review of Chromatography Solutions -- Chapter 9: Particle analytics - Comparative approaches for analysis of viral vectors -- Chapter 10: Phase-Appropriate Potency Assay Development for AAV-based Gene Therapy Products -- Chapter 11: Quantification of virus infectivity - the key assay for the development of viral therapeutics -- Chapter 12: Product-related impurities in therapeutic virus bioprocessing -- Chapter 13: Process Analytical Technologies (PAT) and Quality by Design (QbD) for bioprocessing of virus-based therapeutics -- Chapter 14: Methods and practical considerations in imaging viral therapeutics -- Chapter 15: Application of NMR Spectroscopy in Viral Assembly Characterization -- Chapter 16: Improved Production Strategies for Oncolytic Measles Viruses as a Therapeutic Cancer Treatment -- Chapter 17: Recent Advancements and Challenges in Recombinant Expression for Commercial Production of Virus Like Particles (VLPs) -- Chapter 18: Oncolytic viruses and viral gene therapy vectors: Principles of safety.

This book reviews the knowledge, methods and available techniques in the rapidly advancing field of virus based vaccines and gene therapeutics. It also highlights new innovative tools and interdisciplinary techniques for bioprocess development and analytics of viruses and viral vectors. As such, it provides a timely and highly relevant resource, since current advances in pharmaceutical research have seen the rise of vaccines and advanced therapeutics and medicinal products (ATMPs), that rely on the power of viruses. However, developing bioprocesses and analytics required to create this often called "magic bullet" (i.e. gene therapy) remains an extremely challenging and costly task. This book offers strategies for overcoming hurdles and difficulties within in all the necessary steps of viral vector development - from scalability to purification methods and quality control. The book is intended for researchers working in academia or industry, as well as graduate students pursuing a career in virology.

ISBN: 9783031284892

Standard No.: 10.1007/978-3-031-28489-2doiSubjects--Topical Terms:

644915
Therapeutics.

LC Class. No.: RM411 / .B56 2023

Dewey Class. No.: 615.7924

Bioprocess and analytics development for virus-based advanced therapeutics and medicinal products (ATMPs)
LDR:03830nam a2200325 a 4500 001 1115743
003 DE-He213
005 20230810064504.0
006 m d
007 cr nn 008maaau
008 240123s2023 sz s 0 eng d
020 $a 9783031284892 $q (electronic bk.)
020 $a 9783031284885 $q (paper)
024 7 $a 10.1007/978-3-031-28489-2 $2 doi
035 $a 978-3-031-28489-2
040 $a GP $c GP
041 0 $a eng
050 4 $a RM411 $b .B56 2023
072 7 $a PSGL $2 bicssc
072 7 $a MED052000 $2 bisacsh
072 7 $a PSG $2 thema
082 0 4 $a 615.7924 $2 23
090 $a RM411 $b .B615 2023
245 0 0 $a Bioprocess and analytics development for virus-based advanced therapeutics and medicinal products (ATMPs) $h [electronic resource] / $c edited by Saurabh Gautam, Abhilash I. Chiramel, Roland Pach.
260 $a Cham : $c 2023. $b Springer International Publishing : $b Imprint: Springer,
300 $a xvi, 442 p. : $b ill. (some col.), digital ; $c 24 cm.
505 0 $a Chapter 1: Bioprocessing and analytical development for virus-based therapeutics -- Chapter 2: Viral Vector Upstream Processing and Clarification -- Chapter 3: Upstream processing of viral therapeutics: From host cell expansion to virus production -- Chapter 4: Leveraging virus biology and host genetic conflicts for cell line development and engineering for virus-based therapeutics -- Chapter 5: Overview of Current Downstream Processing for Modern Viral Vectors -- Chapter 6: Filtration Principles and Techniques for Bioprocessing of Viral Vector-Based Therapeutics -- Chapter 7: Chromatographic purification of viruses: State of the art and current trends -- Chapter 8: Purifying Viral Vectors - A Review of Chromatography Solutions -- Chapter 9: Particle analytics - Comparative approaches for analysis of viral vectors -- Chapter 10: Phase-Appropriate Potency Assay Development for AAV-based Gene Therapy Products -- Chapter 11: Quantification of virus infectivity - the key assay for the development of viral therapeutics -- Chapter 12: Product-related impurities in therapeutic virus bioprocessing -- Chapter 13: Process Analytical Technologies (PAT) and Quality by Design (QbD) for bioprocessing of virus-based therapeutics -- Chapter 14: Methods and practical considerations in imaging viral therapeutics -- Chapter 15: Application of NMR Spectroscopy in Viral Assembly Characterization -- Chapter 16: Improved Production Strategies for Oncolytic Measles Viruses as a Therapeutic Cancer Treatment -- Chapter 17: Recent Advancements and Challenges in Recombinant Expression for Commercial Production of Virus Like Particles (VLPs) -- Chapter 18: Oncolytic viruses and viral gene therapy vectors: Principles of safety.
520 $a This book reviews the knowledge, methods and available techniques in the rapidly advancing field of virus based vaccines and gene therapeutics. It also highlights new innovative tools and interdisciplinary techniques for bioprocess development and analytics of viruses and viral vectors. As such, it provides a timely and highly relevant resource, since current advances in pharmaceutical research have seen the rise of vaccines and advanced therapeutics and medicinal products (ATMPs), that rely on the power of viruses. However, developing bioprocesses and analytics required to create this often called "magic bullet" (i.e. gene therapy) remains an extremely challenging and costly task. This book offers strategies for overcoming hurdles and difficulties within in all the necessary steps of viral vector development - from scalability to purification methods and quality control. The book is intended for researchers working in academia or industry, as well as graduate students pursuing a career in virology.
650 2 4 $a Therapeutics. $3 644915
650 2 4 $a Analytical Biochemistry. $3 1389287
650 2 4 $a Microbial Genetics. $3 1366868
650 2 4 $a Biotechnology. $3 554955
650 2 4 $a Biomedical Engineering and Bioengineering. $3 1211019
650 1 4 $a Virology. $3 644995
650 0 $a Viral vaccines. $3 1428685
650 0 $a Antiviral agents. $3 788709
700 1 $a Pach, Roland. $3 1428684
700 1 $a Chiramel, Abhilash I. $3 1428683
700 1 $a Gautam, Saurabh. $3 1428682
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
856 4 0 $u https://doi.org/10.1007/978-3-031-28489-2
950 $a Biomedical and Life Sciences (SpringerNature-11642)