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Drugs and a methodological compendium = from bench to bedside /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Drugs and a methodological compendium/ edited by Vikrant Singh Rajput, Ashish Runthala.
其他題名:	from bench to bedside /
其他作者:	Runthala, Ashish.
出版者:	Singapore :Springer Nature Singapore : : 2023.,
面頁冊數:	xv, 425 p. :ill., digital ; : 24 cm.;
Contained By:	Springer Nature eBook
標題:	Biomedical Research. -
電子資源:	https://doi.org/10.1007/978-981-19-7952-1
ISBN:	9789811979521

Drugs and a methodological compendium = from bench to bedside /
Drugs and a methodological compendiumfrom bench to bedside /[electronic resource] :edited by Vikrant Singh Rajput, Ashish Runthala. - Singapore :Springer Nature Singapore :2023. - xv, 425 p. :ill., digital ;24 cm.

Chapter 1.Computational and informatics methodologies in Drug Discovery, with focus on Natural Products -- Chapter 2.Structural biology an essential tool for Drug discovery and Development -- Chapter 3.Bioactivity guided fractionation and identification of bioactive molecules: A basic method in drug discovery -- Chapter 4.In-vitro methodologies for the safety assessment of drugs -- Chapter 5.In-vivo models for evaluation of Drug efficacy: Demand and Challenges -- Chapter 6.Preclinical In vivo Drug Development Studies: Limitations, Model Organisms and Techniques -- Chapter 7.Peptide Based Therapeutics and Drug Delivery Systems -- Chapter 8.Basics of Clinical Drug Development: Clinical Trial and Drug Development -- Chapter 9.Trailblazing contemporary frameworks for drug repurposing: A saga on drugs' expedition to disinter the veiled destiny -- Chapter 10.Small molecules as promising tool for targeted cancer therapies: an overview of 21st century -- Chapter 11.Nanoparticles for Targeted Drug Delivery Systems with Cancer Therapy in Perspective -- Chapter 12.Biomimetic approach for the controlled drug delivery through 3D bioactive scaffolds: A novel strategy for tissue engineering applications -- Chapter 13.Perspectives on anti-tuberculosis drug discovery -- Chapter 14.Cofactor-Receptor interactions based pharmacophore design for development of novel inhibitors: A case study against Tuberculosis -- Chapter 15.Insilico identification of potential antivirals against SARS-CoV2 main protease and RBD of spike protein - A Drug Repurposing Approach -- Chapter16.Anti-malarial drug discovery and development: from bench to bedside.

This book provides a meticulous view on methodological drug discovery and development insights from bench to bedside. The current book threads almost each step encompassing drug the discovery and development of a molecule. The chapters focus on computational modus operandi, pharmacological optimization approaches, modern high-throughput screening methods and in-vitro procedures, role of structural biologists in drug discovery and development, medicinal chemistry approaches for drug design, formulation and drug delivery, in-vivo evaluations of candidate molecules, clinical trial procedures and others. The book also covers specific case studies, regulatory approval proceedings, and industrial view point alongside the aforementioned conceptual layout. And at the same time, the volume integrates medical, biological, medicinal, pharmacological and computational streams, and it is suggested as an ideal guideline to a wide audience including molecular biologists, biochemist, pharmacologists, medicinal chemist, toxicologists, drug discovery and development researchers, and all other students interested in these disciplines.

ISBN: 9789811979521

Standard No.: 10.1007/978-981-19-7952-1doiSubjects--Topical Terms:

643481
Biomedical Research.

LC Class. No.: RM301

Dewey Class. No.: 615.1

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505 0 $a Chapter 1.Computational and informatics methodologies in Drug Discovery, with focus on Natural Products -- Chapter 2.Structural biology an essential tool for Drug discovery and Development -- Chapter 3.Bioactivity guided fractionation and identification of bioactive molecules: A basic method in drug discovery -- Chapter 4.In-vitro methodologies for the safety assessment of drugs -- Chapter 5.In-vivo models for evaluation of Drug efficacy: Demand and Challenges -- Chapter 6.Preclinical In vivo Drug Development Studies: Limitations, Model Organisms and Techniques -- Chapter 7.Peptide Based Therapeutics and Drug Delivery Systems -- Chapter 8.Basics of Clinical Drug Development: Clinical Trial and Drug Development -- Chapter 9.Trailblazing contemporary frameworks for drug repurposing: A saga on drugs' expedition to disinter the veiled destiny -- Chapter 10.Small molecules as promising tool for targeted cancer therapies: an overview of 21st century -- Chapter 11.Nanoparticles for Targeted Drug Delivery Systems with Cancer Therapy in Perspective -- Chapter 12.Biomimetic approach for the controlled drug delivery through 3D bioactive scaffolds: A novel strategy for tissue engineering applications -- Chapter 13.Perspectives on anti-tuberculosis drug discovery -- Chapter 14.Cofactor-Receptor interactions based pharmacophore design for development of novel inhibitors: A case study against Tuberculosis -- Chapter 15.Insilico identification of potential antivirals against SARS-CoV2 main protease and RBD of spike protein - A Drug Repurposing Approach -- Chapter16.Anti-malarial drug discovery and development: from bench to bedside.
520 $a This book provides a meticulous view on methodological drug discovery and development insights from bench to bedside. The current book threads almost each step encompassing drug the discovery and development of a molecule. The chapters focus on computational modus operandi, pharmacological optimization approaches, modern high-throughput screening methods and in-vitro procedures, role of structural biologists in drug discovery and development, medicinal chemistry approaches for drug design, formulation and drug delivery, in-vivo evaluations of candidate molecules, clinical trial procedures and others. The book also covers specific case studies, regulatory approval proceedings, and industrial view point alongside the aforementioned conceptual layout. And at the same time, the volume integrates medical, biological, medicinal, pharmacological and computational streams, and it is suggested as an ideal guideline to a wide audience including molecular biologists, biochemist, pharmacologists, medicinal chemist, toxicologists, drug discovery and development researchers, and all other students interested in these disciplines.
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