語系:
繁體中文
English
說明(常見問題)
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Targeting the DNA damage response for cancer therapy
紀錄類型:
書目-語言資料,印刷品 : Monograph/item
正題名/作者:
Targeting the DNA damage response for cancer therapy/ edited by Timothy A. Yap, Geoffrey I. Shapiro.
其他作者:
Shapiro, Geoffrey I.
出版者:
Cham :Springer International Publishing : : 2023.,
面頁冊數:
x, 328 p. :illustrations, digital ; : 24 cm.;
Contained By:
Springer Nature eBook
標題:
Pharmacology. -
電子資源:
https://doi.org/10.1007/978-3-031-30065-3
ISBN:
9783031300653
Targeting the DNA damage response for cancer therapy
Targeting the DNA damage response for cancer therapy
[electronic resource] /edited by Timothy A. Yap, Geoffrey I. Shapiro. - Cham :Springer International Publishing :2023. - x, 328 p. :illustrations, digital ;24 cm. - Cancer treatment and research,v. 1862509-8497 ;. - Cancer treatment and research ;v. 114..
Evolution of the development of PARP inhibitors -- Exploiting cancer synthetic lethality in cancer - Lessons learnt from PARP inhibitors -- Mechanisms of PARP inhibitor resistance -- Development of homologous recombination functional assays for targeting the DDR -- Clinical application of Poly(ADP Ribose) Polymerase (PARP) inhibitors in ovarian cancer -- Clinical use of PARP inhibitors in BRCA mutant and non-BRCA mutant breast cancer -- Development of PARP inhibitors in targeting castration-resistant prostate cancer -- Strategies for the management of patients with pancreatic cancer with PARP inhibitors -- Combining poly (ADP-ribose) polymerase (PARP) inhibitors with chemotherapeutic agents: Promise and challenges -- Rational combinations of PARP inhibitors with HRD-inducing molecularly targeted agents -- Combining PARP inhibition and immunotherapy in BRCA-associated cancers -- Mitotic MTH1 inhibitors in treatment of cancer -- Targeting ATR in cancer medicine -- Targeting polymerase Theta (POLq) for cancer therapy -- Targeting DNA-PK -- WRN is a promising synthetic lethal target for cancers with microsatellite instability (MSI)
This book discusses the latest developments in Poly (ADP-ribose) polymerase (PARP) inhibitor drug development. It focuses on the translational and clinical development of the latest drugs, as well as the evidence for regulatory approval of PARP inhibitors in multiple different molecular subtypes and tumor indications. The most-up-to-date information on basic scientific research on DNA repair pathways and the DNA Damage Response (DDR) is also covered. Every chapter contains insight into the preclinical, translational along with clinical aspects of a specific DDR inhibitor with key and expert opinion points reinforcing the most important concepts detailed to enable the reader to develop a deep understanding of the topic. Targeting the DNA Damage Response for Cancer Therapy comprehensively reviews the application of PARP and other DDR inhibitors across oncology disciplines. Therefore, it is a valuable resource for all medical professionals and researchers who use or who are researching the use of these inhibitors on a day-to-day basis.
ISBN: 9783031300653
Standard No.: 10.1007/978-3-031-30065-3doiSubjects--Topical Terms:
583819
Pharmacology.
LC Class. No.: RC270.8
Dewey Class. No.: 616.99406
Targeting the DNA damage response for cancer therapy
LDR
:03253nam a2200337 a 4500
001
1119911
003
DE-He213
005
20231117181003.0
006
m d
007
cr nn 008maaau
008
240612s2023 sz s 0 eng d
020
$a
9783031300653
$q
(electronic bk.)
020
$a
9783031300646
$q
(paper)
024
7
$a
10.1007/978-3-031-30065-3
$2
doi
035
$a
978-3-031-30065-3
040
$a
GP
$c
GP
041
0
$a
eng
050
4
$a
RC270.8
072
7
$a
MJCL
$2
bicssc
072
7
$a
MED062000
$2
bisacsh
072
7
$a
MJCL
$2
thema
082
0 4
$a
616.99406
$2
23
090
$a
RC270.8
$b
.T185 2023
245
0 0
$a
Targeting the DNA damage response for cancer therapy
$h
[electronic resource] /
$c
edited by Timothy A. Yap, Geoffrey I. Shapiro.
260
$a
Cham :
$c
2023.
$b
Springer International Publishing :
$b
Imprint: Springer,
300
$a
x, 328 p. :
$b
illustrations, digital ;
$c
24 cm.
490
1
$a
Cancer treatment and research,
$x
2509-8497 ;
$v
v. 186
505
0
$a
Evolution of the development of PARP inhibitors -- Exploiting cancer synthetic lethality in cancer - Lessons learnt from PARP inhibitors -- Mechanisms of PARP inhibitor resistance -- Development of homologous recombination functional assays for targeting the DDR -- Clinical application of Poly(ADP Ribose) Polymerase (PARP) inhibitors in ovarian cancer -- Clinical use of PARP inhibitors in BRCA mutant and non-BRCA mutant breast cancer -- Development of PARP inhibitors in targeting castration-resistant prostate cancer -- Strategies for the management of patients with pancreatic cancer with PARP inhibitors -- Combining poly (ADP-ribose) polymerase (PARP) inhibitors with chemotherapeutic agents: Promise and challenges -- Rational combinations of PARP inhibitors with HRD-inducing molecularly targeted agents -- Combining PARP inhibition and immunotherapy in BRCA-associated cancers -- Mitotic MTH1 inhibitors in treatment of cancer -- Targeting ATR in cancer medicine -- Targeting polymerase Theta (POLq) for cancer therapy -- Targeting DNA-PK -- WRN is a promising synthetic lethal target for cancers with microsatellite instability (MSI)
520
$a
This book discusses the latest developments in Poly (ADP-ribose) polymerase (PARP) inhibitor drug development. It focuses on the translational and clinical development of the latest drugs, as well as the evidence for regulatory approval of PARP inhibitors in multiple different molecular subtypes and tumor indications. The most-up-to-date information on basic scientific research on DNA repair pathways and the DNA Damage Response (DDR) is also covered. Every chapter contains insight into the preclinical, translational along with clinical aspects of a specific DDR inhibitor with key and expert opinion points reinforcing the most important concepts detailed to enable the reader to develop a deep understanding of the topic. Targeting the DNA Damage Response for Cancer Therapy comprehensively reviews the application of PARP and other DDR inhibitors across oncology disciplines. Therefore, it is a valuable resource for all medical professionals and researchers who use or who are researching the use of these inhibitors on a day-to-day basis.
650
2 4
$a
Pharmacology.
$3
583819
650
2 4
$a
Radiation Oncology.
$3
1388865
650
1 4
$a
Oncology.
$3
593951
650
0
$a
DNA repair.
$3
582917
650
0
$a
DNA damage.
$3
582916
650
0
$a
Cancer
$x
Treatment.
$3
661325
700
1
$a
Shapiro, Geoffrey I.
$3
1434822
700
1
$a
Yap, Timothy A.
$e
editor.
$3
1325896
710
2
$a
SpringerLink (Online service)
$3
593884
773
0
$t
Springer Nature eBook
830
0
$a
Cancer treatment and research ;
$v
v. 114.
$3
893632
856
4 0
$u
https://doi.org/10.1007/978-3-031-30065-3
950
$a
Medicine (SpringerNature-11650)
筆 0 讀者評論
多媒體
評論
新增評論
分享你的心得
Export
取書館別
處理中
...
變更密碼[密碼必須為2種組合(英文和數字)及長度為10碼以上]
登入