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An introduction to medicinal chemistry /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	An introduction to medicinal chemistry // Graham L. Patrick.
作者:	Patrick, Graham L.
出版者:	Oxford, UK :Oxford University Press, : c2023.,
面頁冊數:	xxx, 925 p. :ill. (some col.) ; : 28 cm.;
附註:	Revised edition of: An introduction to medicinal chemistry / Graham L. Patrick. Sixth edition. 2017.
標題:	Pharmaceutical chemistry. -
ISBN:	9780198866664 (pbk. : standard ed.)

An introduction to medicinal chemistry /
Patrick, Graham L.

An introduction to medicinal chemistry /Graham L. Patrick. - 7th ed. - Oxford, UK :Oxford University Press,c2023. - xxx, 925 p. :ill. (some col.) ;28 cm.

Revised edition of: An introduction to medicinal chemistry / Graham L. Patrick. Sixth edition. 2017.

Includes bibliographical references (p. [905]-906) and index.

1. Drugs and drug targets: an overview -- Part A. Drug targets: structure and function. 2. Protein structure and function -- 3. Enzymes: structure and function -- 4. Receptors: structure and function -- 5. Receptors and signal transaction -- 6. Nucleic acids: structure and function -- Part B. Pharmacodynamics and pharmacokinetics. 7. Enzymes as drug targets -- 8. Receptors as drug targets -- 9. Nucleic acids as drug targets -- 10. Miscellaneous drug targets -- 11. Pharmacokinetics and related topics -- Case study 1 Statins -- Part C. Drug discovery, design, and development. 12. Drug discovery: finding a lead -- 13. Drug design: optimizing target interactions -- 14. Drug design: optimizing access to the target -- 15. Getting the drug to market -- Case study 2 The design of ACE inhibitors -- Case study 3 Artemisinin and related antimalarial drugs -- Case study 4 The design of oxamniquine -- Case study 5 Fosmidomycin as an antimalarial agent -- Part D. Tools of the trade. 16. Combinatorial and parallel synthesis -- 17. In silico drug design -- 18. Quantitative structure-activity relationships (QSAR) -- Case study 6 Design of a thymidylate synthase inhibitor -- Part E. Selected topics in medicinal chemistry. 19. Antibacterial agents -- 20. Antiviral agents -- 21. Anticancer agents -- 22. Protein kinase inhibitors as anticancer agents -- 23. Antibodies and other biologics -- 24. Cholinergics, anticholinergics, and anticholinesterases -- 25. Drugs acting on the adrenergic nervous system -- 26. The opioid analgesics -- 27. Anti-ulcer agents -- 28. Cardiovascular drugs -- Case study 7 Steroidal anti-inflammatory agents -- Case study 8 Current research into antidepressant agents -- Case study 9 The design and development of aliskiren -- Case study 10 Factor Xa inhibitors -- Case study 11 Reversible inhibitors of HCV NS3-4A protease -- Appendix 1. Essential amino acids -- Appendix 2. The standard genetic code -- Appendix 3. Statistical data for QSAR -- Appendix 4. The action of nerves -- Appendix 5. Microorganisms -- Appendix 6. Drugs and their trade names -- Appendix 7. Trade name (drug name) -- Appendix 8. Potential hydrogen bond donors (HBDs) and hydrogen bond acceptors (HBAs) in common functional groups -- Appendix 9. Using the Protein Data Bank.

Providing an introduction to medicinal chemistry, this resource covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug.

ISBN: 9780198866664 (pbk. : standard ed.)

LCCN: 2022944304

Nat. Bib. No.: GBC317893bnbSubjects--Topical Terms:

581965
Pharmaceutical chemistry.

LC Class. No.: RS403 / .P38 2023

Dewey Class. No.: 615.19

National Library of Medicine Call No.: QV 744

An introduction to medicinal chemistry /
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245 1 3 $a An introduction to medicinal chemistry / $c Graham L. Patrick.
250 $a 7th ed.
260 # $a Oxford, UK : $b Oxford University Press, $c c2023.
300 $a xxx, 925 p. : $b ill. (some col.) ; $c 28 cm.
500 $a Revised edition of: An introduction to medicinal chemistry / Graham L. Patrick. Sixth edition. 2017.
500 $a "Fourth edition 2009, Fifth edition 2013, Sixth edition 2017"--copyright page.
504 $a Includes bibliographical references (p. [905]-906) and index.
505 0 # $a 1. Drugs and drug targets: an overview -- Part A. Drug targets: structure and function. 2. Protein structure and function -- 3. Enzymes: structure and function -- 4. Receptors: structure and function -- 5. Receptors and signal transaction -- 6. Nucleic acids: structure and function -- Part B. Pharmacodynamics and pharmacokinetics. 7. Enzymes as drug targets -- 8. Receptors as drug targets -- 9. Nucleic acids as drug targets -- 10. Miscellaneous drug targets -- 11. Pharmacokinetics and related topics -- Case study 1 Statins -- Part C. Drug discovery, design, and development. 12. Drug discovery: finding a lead -- 13. Drug design: optimizing target interactions -- 14. Drug design: optimizing access to the target -- 15. Getting the drug to market -- Case study 2 The design of ACE inhibitors -- Case study 3 Artemisinin and related antimalarial drugs -- Case study 4 The design of oxamniquine -- Case study 5 Fosmidomycin as an antimalarial agent -- Part D. Tools of the trade. 16. Combinatorial and parallel synthesis -- 17. In silico drug design -- 18. Quantitative structure-activity relationships (QSAR) -- Case study 6 Design of a thymidylate synthase inhibitor -- Part E. Selected topics in medicinal chemistry. 19. Antibacterial agents -- 20. Antiviral agents -- 21. Anticancer agents -- 22. Protein kinase inhibitors as anticancer agents -- 23. Antibodies and other biologics -- 24. Cholinergics, anticholinergics, and anticholinesterases -- 25. Drugs acting on the adrenergic nervous system -- 26. The opioid analgesics -- 27. Anti-ulcer agents -- 28. Cardiovascular drugs -- Case study 7 Steroidal anti-inflammatory agents -- Case study 8 Current research into antidepressant agents -- Case study 9 The design and development of aliskiren -- Case study 10 Factor Xa inhibitors -- Case study 11 Reversible inhibitors of HCV NS3-4A protease -- Appendix 1. Essential amino acids -- Appendix 2. The standard genetic code -- Appendix 3. Statistical data for QSAR -- Appendix 4. The action of nerves -- Appendix 5. Microorganisms -- Appendix 6. Drugs and their trade names -- Appendix 7. Trade name (drug name) -- Appendix 8. Potential hydrogen bond donors (HBDs) and hydrogen bond acceptors (HBAs) in common functional groups -- Appendix 9. Using the Protein Data Bank.
520 8 $a Providing an introduction to medicinal chemistry, this resource covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug.
650 # 0 $a Pharmaceutical chemistry. $3 581965
650 # 2 $a Chemistry, Pharmaceutical. $3 582412