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Exploring Relationships between Peripheral Inflammation and Resting-State Functional Connectivity in Two Chronic Inflammation-Prone Samples.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Exploring Relationships between Peripheral Inflammation and Resting-State Functional Connectivity in Two Chronic Inflammation-Prone Samples./
Author:	YorkWilliams, Sophie L.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
Description:	73 p.
Notes:	Source: Dissertations Abstracts International, Volume: 83-03, Section: B.
Contained By:	Dissertations Abstracts International83-03B.
Subject:	Clinical psychology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28651857
ISBN:	9798538131549

Exploring Relationships between Peripheral Inflammation and Resting-State Functional Connectivity in Two Chronic Inflammation-Prone Samples.
YorkWilliams, Sophie L.

Exploring Relationships between Peripheral Inflammation and Resting-State Functional Connectivity in Two Chronic Inflammation-Prone Samples. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 73 p.

Source: Dissertations Abstracts International, Volume: 83-03, Section: B.

Thesis (Ph.D.)--University of Colorado at Boulder, 2021.

This item must not be sold to any third party vendors.

Alcohol use disorder (AUD) and age-related executive dysfunction are pervasive and neurobiologically complex conditions with large public health burdens. While research continues to elucidate the mechanisms underlying their development and maintenance, both conditions are associated with chronic peripheral inflammation and with functional brain changes in the default mode and frontoparietal control networks (DMN and FPCN). Whether these two phenomena are connected has not been adequately explored in either AUD or age-related executive decline. The present study examines whether this link exists in a sample of adults with AUD, and in a sample of sedentary older adults, using cross-sectional data from two parent studies. Namely, it examines whether region-to-region functional connectivity within the DMN and FPCN are associated with peripheral inflammation as measured by plasma levels of key inflammatory proteins (interleukin 1-beta, interleukin 6, and tumor necrosis factor alpha). In the AUD sample, connectivity changes within both DMN and FPCN occurred as peripheral inflammation increased, and results remained after controlling for participant age. In the sedentary older-adult sample, neuroimaging results did not survive correction for false discovery rate, but DMN and FPCN associations with peripheral inflammation were observed at uncorrected thresholds. Results provide support for continued exploration of aging- and AUD-related changes in neuroimmune communication. The study’s methodological considerations, clinical significance, and future directions are explored.

ISBN: 9798538131549Subjects--Topical Terms:

649607
Clinical psychology.
Subjects--Index Terms:

Age-related cognitive decline

Exploring Relationships between Peripheral Inflammation and Resting-State Functional Connectivity in Two Chronic Inflammation-Prone Samples.
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520 $a Alcohol use disorder (AUD) and age-related executive dysfunction are pervasive and neurobiologically complex conditions with large public health burdens. While research continues to elucidate the mechanisms underlying their development and maintenance, both conditions are associated with chronic peripheral inflammation and with functional brain changes in the default mode and frontoparietal control networks (DMN and FPCN). Whether these two phenomena are connected has not been adequately explored in either AUD or age-related executive decline. The present study examines whether this link exists in a sample of adults with AUD, and in a sample of sedentary older adults, using cross-sectional data from two parent studies. Namely, it examines whether region-to-region functional connectivity within the DMN and FPCN are associated with peripheral inflammation as measured by plasma levels of key inflammatory proteins (interleukin 1-beta, interleukin 6, and tumor necrosis factor alpha). In the AUD sample, connectivity changes within both DMN and FPCN occurred as peripheral inflammation increased, and results remained after controlling for participant age. In the sedentary older-adult sample, neuroimaging results did not survive correction for false discovery rate, but DMN and FPCN associations with peripheral inflammation were observed at uncorrected thresholds. Results provide support for continued exploration of aging- and AUD-related changes in neuroimmune communication. The study’s methodological considerations, clinical significance, and future directions are explored.
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