國立虎尾科技大學 |

Human challenge studies for vaccine development

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Human challenge studies for vaccine development/ edited by Fabio Bagnoli ... [et al.].
其他作者:	Bagnoli, Fabio.
出版者:	Cham :Springer Nature Switzerland : : 2024.,
面頁冊數:	viii, 377 p. :ill. (some col.), digital ; : 24 cm.;
Contained By:	Springer Nature eBook
標題:	Pathogenesis. -
電子資源:	https://doi.org/10.1007/978-3-031-63118-4
ISBN:	9783031631184

Human challenge studies for vaccine development
Human challenge studies for vaccine development[electronic resource] /edited by Fabio Bagnoli ... [et al.]. - Cham :Springer Nature Switzerland :2024. - viii, 377 p. :ill. (some col.), digital ;24 cm. - Current topics in microbiology and immunology,v. 4452196-9965 ;. - Current topics in microbiology and immunology ;v.355..

A brief history of human challenge studies (1900-2021) emphasising the virology, regulatory and ethical requirements, raison d'etre, ethnography, selection of volunteers and unit design -- Regulatory aspects of human challenge studies -- Controlled Human Infection challenge studies with RSV -- Human challenge studies with coronaviruses old and new -- Experimental urethral infection with Neisseria gonorrhoeae -- Helicobacter pylori -- Controlled human infection with Bordetella pertussis Human challenge studies for cholera -- The Controlled Human Infection Model for Enterotoxigenic Escherichia coli -- Challenges in developing a controlled human tuberculosis challenge model -- Shigella Controlled Human Infection Models: Current and Future Perspectives -- The background, role and outline approach for development of a Controlled Human Infection Model for Nontyphoidal Salmonella -- Controlled Human Malaria Infection studies in Africa - past, present, and future -- Controlled infection of humans with the hookworm parasite Necator americanus to accelerate vaccine development.

This volume offers insights into human challenge studies, where adult volunteers are deliberately infected with a pathogen of interest. These studies can broaden our knowledge on infections that have a rather low natural infection rate, but still bear a great threat to global health. The authors also present instances, where no suitable animal model is available to help understand human immune responses to a specific pathogen. The recent SARS-CoV-2 pandemic is another example, where studies that are directly conducted in humans, could save valuable time. Human challenge studies can provide immunogenicity and early efficacy data for vaccine development. However, similar models could be used for studying a wide variety of medical treatments such as monoclonal antibodies, antibiotics, antivirals and bacteriophages. The chapters in this volume cover several pathogens, including viruses, bacteria and parasites, scientific and technical aspects as well as descriptions of regulatory, ethical and manufacturing requirements. The book serves as a valuable resource for scientists and clinicians working on human pathogens.

ISBN: 9783031631184

Standard No.: 10.1007/978-3-031-63118-4doiSubjects--Topical Terms:

1390667
Pathogenesis.

LC Class. No.: RM281

Dewey Class. No.: 615.372

Human challenge studies for vaccine development
LDR:03294nam a2200337 a 4500 001 1138113
003 DE-He213
005 20241027115928.0
006 m d
007 cr nn 008maaau
008 250117s2024 sz s 0 eng d
020 $a 9783031631184 $q (electronic bk.)
020 $a 9783031631177 $q (paper)
024 7 $a 10.1007/978-3-031-63118-4 $2 doi
035 $a 978-3-031-63118-4
040 $a GP $c GP
041 0 $a eng
050 4 $a RM281
072 7 $a MJCM $2 bicssc
072 7 $a MED044000 $2 bisacsh
072 7 $a MJCM $2 thema
082 0 4 $a 615.372 $2 23
090 $a RM281 $b .H918 2024
245 0 0 $a Human challenge studies for vaccine development $h [electronic resource] / $c edited by Fabio Bagnoli ... [et al.].
260 $a Cham : $c 2024. $b Springer Nature Switzerland : $b Imprint: Springer,
300 $a viii, 377 p. : $b ill. (some col.), digital ; $c 24 cm.
490 1 $a Current topics in microbiology and immunology, $x 2196-9965 ; $v v. 445
505 0 $a A brief history of human challenge studies (1900-2021) emphasising the virology, regulatory and ethical requirements, raison d'etre, ethnography, selection of volunteers and unit design -- Regulatory aspects of human challenge studies -- Controlled Human Infection challenge studies with RSV -- Human challenge studies with coronaviruses old and new -- Experimental urethral infection with Neisseria gonorrhoeae -- Helicobacter pylori -- Controlled human infection with Bordetella pertussis Human challenge studies for cholera -- The Controlled Human Infection Model for Enterotoxigenic Escherichia coli -- Challenges in developing a controlled human tuberculosis challenge model -- Shigella Controlled Human Infection Models: Current and Future Perspectives -- The background, role and outline approach for development of a Controlled Human Infection Model for Nontyphoidal Salmonella -- Controlled Human Malaria Infection studies in Africa - past, present, and future -- Controlled infection of humans with the hookworm parasite Necator americanus to accelerate vaccine development.
520 $a This volume offers insights into human challenge studies, where adult volunteers are deliberately infected with a pathogen of interest. These studies can broaden our knowledge on infections that have a rather low natural infection rate, but still bear a great threat to global health. The authors also present instances, where no suitable animal model is available to help understand human immune responses to a specific pathogen. The recent SARS-CoV-2 pandemic is another example, where studies that are directly conducted in humans, could save valuable time. Human challenge studies can provide immunogenicity and early efficacy data for vaccine development. However, similar models could be used for studying a wide variety of medical treatments such as monoclonal antibodies, antibiotics, antivirals and bacteriophages. The chapters in this volume cover several pathogens, including viruses, bacteria and parasites, scientific and technical aspects as well as descriptions of regulatory, ethical and manufacturing requirements. The book serves as a valuable resource for scientists and clinicians working on human pathogens.
650 2 4 $a Pathogenesis. $3 1390667
650 2 4 $a Translational Research. $3 1389283
650 2 4 $a Medical Microbiology. $3 668401
650 1 4 $a Immunology. $3 592892
650 0 $a Human experimentation in medicine. $3 577679
650 0 $a Vaccines. $3 582184
700 1 $a Bagnoli, Fabio. $3 1142112
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
830 0 $a Current topics in microbiology and immunology ; $v v.355. $3 882363
856 4 0 $u https://doi.org/10.1007/978-3-031-63118-4
950 $a Biomedical and Life Sciences (SpringerNature-11642)