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Toward a Biomarker for Spatial Hearing Ability.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Toward a Biomarker for Spatial Hearing Ability./
Author:	Owrutsky, Zoe Lauren.
Description:	1 online resource (113 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-03, Section: B.
Contained By:	Dissertations Abstracts International85-03B.
Subject:	Neurosciences. -
Online resource:	click for full text (PQDT)
ISBN:	9798380150262

Toward a Biomarker for Spatial Hearing Ability.
Owrutsky, Zoe Lauren.

Toward a Biomarker for Spatial Hearing Ability. - 1 online resource (113 pages)

Source: Dissertations Abstracts International, Volume: 85-03, Section: B.

Thesis (Ph.D.)--University of Colorado Denver, Anschutz Medical Campus, 2023.

Includes bibliographical references

An increasing population, spanning infancy through elderly and of diverse etiology, experiences difficulty communicating in complex acoustic environments despite often having normal audiometric thresholds. However, diagnosing spatial or binaural hearing deficits remains a major clinical challenge as no objective clinical measures are available to test for it. Stimulus-evoked potentials enable noninvasive assessment of sensory function. Sound-evoked auditory brainstem responses (ABRs) are one such potential commonly used for audiological assessment. The peaks in an ABR derive from synchronous neural activity at ascending nodes of the auditory brainstem. Over the past several decades, a derived component of the ABR, the binaural interaction component (BIC), has generated interest as a potential biomarker of binaural hearing. Decades of research have established a clear link between the BIC and binaural hearing ability. However, it is often variable and unreliably measured in humans using standard methodology. Understanding the specific brainstem circuits underlying the BIC could help explain its unreliable nature, improve methods for its measurement, and improve its clinical utility as an objective diagnostic biomarker. The overarching theme of this body of work is to fill this knowledge gap by determining conclusively the brainstem nuclei underlying the BIC using transient and reversible optogenetic manipulations in the auditory brainstem while directly evaluating the effect on the BIC. Additionally, we sought to improve measurability and reduce variability in human subjects by determining the optimal stimulus for evoking the BIC. Together, these studies shed new light on the mechanisms of binaural processing underlying the elusive BIC of the ABR and improve its clinical utility as a potential biomarker for spatial hearing ability.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798380150262Subjects--Topical Terms:

593561
Neurosciences.
Subjects--Index Terms:

Auditory brainstem responseIndex Terms--Genre/Form:

554714
Electronic books.

Toward a Biomarker for Spatial Hearing Ability.
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504 $a Includes bibliographical references
520 $a An increasing population, spanning infancy through elderly and of diverse etiology, experiences difficulty communicating in complex acoustic environments despite often having normal audiometric thresholds. However, diagnosing spatial or binaural hearing deficits remains a major clinical challenge as no objective clinical measures are available to test for it. Stimulus-evoked potentials enable noninvasive assessment of sensory function. Sound-evoked auditory brainstem responses (ABRs) are one such potential commonly used for audiological assessment. The peaks in an ABR derive from synchronous neural activity at ascending nodes of the auditory brainstem. Over the past several decades, a derived component of the ABR, the binaural interaction component (BIC), has generated interest as a potential biomarker of binaural hearing. Decades of research have established a clear link between the BIC and binaural hearing ability. However, it is often variable and unreliably measured in humans using standard methodology. Understanding the specific brainstem circuits underlying the BIC could help explain its unreliable nature, improve methods for its measurement, and improve its clinical utility as an objective diagnostic biomarker. The overarching theme of this body of work is to fill this knowledge gap by determining conclusively the brainstem nuclei underlying the BIC using transient and reversible optogenetic manipulations in the auditory brainstem while directly evaluating the effect on the BIC. Additionally, we sought to improve measurability and reduce variability in human subjects by determining the optimal stimulus for evoking the BIC. Together, these studies shed new light on the mechanisms of binaural processing underlying the elusive BIC of the ABR and improve its clinical utility as a potential biomarker for spatial hearing ability.
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653 $a Spatial hearing
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