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Involvement of α1-Adrenergic Receptors in Angiotensin II-Mediated Blood Pressure Changes in the Channel Catfish, Ictalurus punctatus.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Involvement of α1-Adrenergic Receptors in Angiotensin II-Mediated Blood Pressure Changes in the Channel Catfish, Ictalurus punctatus./
Author:	Lewis, Katelynn.
Description:	1 online resource (37 pages)
Notes:	Source: Masters Abstracts International, Volume: 85-06.
Contained By:	Masters Abstracts International85-06.
Subject:	Biology. -
Online resource:	click for full text (PQDT)
ISBN:	9798381181845

Involvement of α1-Adrenergic Receptors in Angiotensin II-Mediated Blood Pressure Changes in the Channel Catfish, Ictalurus punctatus.
Lewis, Katelynn.

Involvement of α1-Adrenergic Receptors in Angiotensin II-Mediated Blood Pressure Changes in the Channel Catfish, Ictalurus punctatus. - 1 online resource (37 pages)

Source: Masters Abstracts International, Volume: 85-06.

Thesis (M.S.)--Tarleton State University, 2023.

Includes bibliographical references

The renin-angiotensin system (RAS) evolved during the early evolution of vertebrates and has been highly conserved throughout vertebrate evolution, suggesting a fundamental physiological role. The RAS produces the humoral factor, angiotensin II (ANG II), which is responsible for regulating blood pressure (BP) and blood volume. Research on the mechanisms involved in the ANG II-mediated BP response is limited in teleost fishes. The goal of the study was to determine the role of α1-adrenergic receptors in the BP response to ANG II in the channel catfish (I. punctatus) by measuring the dorsal aortic pressure (PDA) and heart rate (HR) response to ANG II before and after treatment with the α1-adrenergic antagonist, prazosin. Prazosin treatment decreased PDA from baseline levels, suggesting α1-adrenergic mechanisms play a role in tonic maintenance of BP. In addition, the peak PDA response to ANG II was not significantly affected by prazosin treatment, suggesting α1-adrenergic mechanisms do not play a role in the ANG II-mediated peak PDA response. Prazosin treatment also reversed the ANG II-mediated HR response, suggesting α1-adrenergic mechanisms play a role in ANG II's ability to attenuate the arterial baroreflex control of HR. Experimentation blocking a higher percentage of α1-adrenoreceptors would provide further clarification regarding the role of α1-adrenergic mechanisms in the ANG II-mediated BP regulation. Additionally, experimentation measuring plasma catecholamine concentrations and hemodynamic parameters such as cardiac output, vascular resistance and stroke volume, would provide insights on the source of catecholamines and the cardiovascular changes responsible for the ANG II-mediated BP response. Ultimately, this study allows for a more extensive comparative analysis of the RAS between teleost species. In addition, research from non-mammalian species may provide insights on more advanced RAS mechanisms in mammals to assist in the development of treatment therapies for common cardiovascular and renal conditions.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798381181845Subjects--Topical Terms:

599573
Biology.
Subjects--Index Terms:

Channel catfishIndex Terms--Genre/Form:

554714
Electronic books.

Involvement of α1-Adrenergic Receptors in Angiotensin II-Mediated Blood Pressure Changes in the Channel Catfish, Ictalurus punctatus.
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