國立虎尾科技大學 |

Development and Characterization of Shear Thinning CNF-Tempo Hydrogels for Use in Aquaculture Vaccines.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	Development and Characterization of Shear Thinning CNF-Tempo Hydrogels for Use in Aquaculture Vaccines./
作者:	Holbrook, Jacob A.
面頁冊數:	1 online resource (81 pages)
附註:	Source: Masters Abstracts International, Volume: 85-06.
Contained By:	Masters Abstracts International85-06.
標題:	Biomedical engineering. -
電子資源:	click for full text (PQDT)
ISBN:	9798380871457

Development and Characterization of Shear Thinning CNF-Tempo Hydrogels for Use in Aquaculture Vaccines.
Holbrook, Jacob A.

Development and Characterization of Shear Thinning CNF-Tempo Hydrogels for Use in Aquaculture Vaccines. - 1 online resource (81 pages)

Source: Masters Abstracts International, Volume: 85-06.

Thesis (M.S.)--The University of Maine, 2023.

Includes bibliographical references

Aquaculture has shown significant growth within the past few decades and is expected to continue expanding rapidly as the global demand for fish consumption continues to increase. A significant loss within the aquaculture industry is due to pathogen transmission within the farm systems. These pathogens are mitigated through various methods that are not cost effective or have limited protection. The most common method of pathogen mitigation is through oil-based injection vaccines as they provide even protection across vaccinated fish and provides the longest protection compared to other vaccination methods. These oil-based injection vaccines are not without their flaws as they require multiple injections throughout the lifecycle of the fish which creates unwanted handling and increased costs. Oil-based injection vaccines have also been shown to cause adverse reactions within the fish. From preliminary tests, it was determined that cellulose nanomaterials have minimal adverse reactions when injected and does not significantly affect the growth of the fish. The goal of this research was to develop an improved adjuvant that can create an immune response comparable to the current mineral oil-based adjuvant, decrease adverse effects, and improve the time of immunity. The ability for the developed adjuvant to have a prolonged release of antigen would remove the need for multiple injections that are currently used for long term immunity. One method for prolonged release of materials is with hydrogels which are currently being used in drug diffusion applications. A cellulose nanomaterial polymer hydrogel matrix offers improved biocompatibility, sustainability, tunability, and affordability. The development of a physically crosslinked hydrogel formulation and the modifications required for ease of delivery was first attempted. Even with modification these physically crosslinked hydrogels were too invasive and time intensive. The development of a chemically modified, shear thinning cellulose nanomaterial polymer was then synthesized, modified for improved injection characteristics, assessed for mechanical properties, assessed for chemical properties, and in vivo tested for the analysis of adverse reactions and ease of administration compared to the physically crosslinked hydrogel.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798380871457Subjects--Topical Terms:

588770
Biomedical engineering.
Subjects--Index Terms:

AquacultureIndex Terms--Genre/Form:

554714
Electronic books.

Development and Characterization of Shear Thinning CNF-Tempo Hydrogels for Use in Aquaculture Vaccines.
LDR:03631ntm a2200373K 4500 001 1141523
005 20240315085605.5
006 m o d
007 cr mn ---uuuuu
008 250605s2023 xx obm 000 0 eng d
020 $a 9798380871457
035 $a (MiAaPQ)AAI30973339
035 $a (MiAaPQ)U_Maine4884
035 $a AAI30973339
040 $a MiAaPQ $b eng $c MiAaPQ $d NTU
100 1 $a Holbrook, Jacob A. $3 1465358
245 1 0 $a Development and Characterization of Shear Thinning CNF-Tempo Hydrogels for Use in Aquaculture Vaccines.
264 0 $c 2023
300 $a 1 online resource (81 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Masters Abstracts International, Volume: 85-06.
500 $a Advisor: Mason, Michael.
502 $a Thesis (M.S.)--The University of Maine, 2023.
504 $a Includes bibliographical references
520 $a Aquaculture has shown significant growth within the past few decades and is expected to continue expanding rapidly as the global demand for fish consumption continues to increase. A significant loss within the aquaculture industry is due to pathogen transmission within the farm systems. These pathogens are mitigated through various methods that are not cost effective or have limited protection. The most common method of pathogen mitigation is through oil-based injection vaccines as they provide even protection across vaccinated fish and provides the longest protection compared to other vaccination methods. These oil-based injection vaccines are not without their flaws as they require multiple injections throughout the lifecycle of the fish which creates unwanted handling and increased costs. Oil-based injection vaccines have also been shown to cause adverse reactions within the fish. From preliminary tests, it was determined that cellulose nanomaterials have minimal adverse reactions when injected and does not significantly affect the growth of the fish. The goal of this research was to develop an improved adjuvant that can create an immune response comparable to the current mineral oil-based adjuvant, decrease adverse effects, and improve the time of immunity. The ability for the developed adjuvant to have a prolonged release of antigen would remove the need for multiple injections that are currently used for long term immunity. One method for prolonged release of materials is with hydrogels which are currently being used in drug diffusion applications. A cellulose nanomaterial polymer hydrogel matrix offers improved biocompatibility, sustainability, tunability, and affordability. The development of a physically crosslinked hydrogel formulation and the modifications required for ease of delivery was first attempted. Even with modification these physically crosslinked hydrogels were too invasive and time intensive. The development of a chemically modified, shear thinning cellulose nanomaterial polymer was then synthesized, modified for improved injection characteristics, assessed for mechanical properties, assessed for chemical properties, and in vivo tested for the analysis of adverse reactions and ease of administration compared to the physically crosslinked hydrogel.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2024
538 $a Mode of access: World Wide Web
650 4 $a Biomedical engineering. $3 588770
650 4 $a Aquatic sciences. $3 1178821
653 $a Aquaculture
653 $a Aquaculture vaccines
653 $a Shear thinning
655 7 $a Electronic books. $2 local $3 554714
690 $a 0541
690 $a 0792
710 2 $a The University of Maine. $3 845490
710 2 $a ProQuest Information and Learning Co. $3 1178819
773 0 $t Masters Abstracts International $g 85-06.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30973339 $z click for full text (PQDT)