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Evaluating the Role of the Bovine Vaginal Microbiome in Neonatal and Maternal Health Outcomes.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Evaluating the Role of the Bovine Vaginal Microbiome in Neonatal and Maternal Health Outcomes./
Author:	Messman, Riley D. .
Description:	1 online resource (158 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-02, Section: B.
Contained By:	Dissertations Abstracts International85-02B.
Subject:	Animal sciences. -
Online resource:	click for full text (PQDT)
ISBN:	9798380119696

Evaluating the Role of the Bovine Vaginal Microbiome in Neonatal and Maternal Health Outcomes.
Messman, Riley D. .

Evaluating the Role of the Bovine Vaginal Microbiome in Neonatal and Maternal Health Outcomes. - 1 online resource (158 pages)

Source: Dissertations Abstracts International, Volume: 85-02, Section: B.

Thesis (Ph.D.)--Mississippi State University, 2023.

Includes bibliographical references

The dam vaginal microbiota is the first major microbial inoculating community within the neonate. The composition of the dam vaginal microbiota has implications in calf commensal microbiota development. Alterations of the dam microbial community prior to parturition could alter inoculating communities and immune responses in both the dam and calf. Thus, authors aimed to elucidate the microbial community composition of the bovine dam vaginal and calf nasal microbiota post-partum after utilizing betadine lavages (BL). The dam vaginal and calf nasal microbial communities and immune responses were evaluated at 0-, 15-, 30- and 60-day post-partum. Microbiota composition of the dam haircoat, udder, and IgG in the colostrum/calf sera were also evaluated at day 0. Serial BLG prior to parturition did not alter the alpha diversity of the dam-vaginal microbiota but did alter the calf-nasal microbiota at parturition (P = 0.03). Dams receiving BLG prior to calving had increased colostrum IgG concentrations compared to CON dams (P =0.04). These results suggest physiological insults (BLG) prior to parturition led to an increased immune response which altering dam colostrum IgG. Thus, neonatal colostrum consumption could drive immune responses against inoculating bacteria resulting in differing nasal microbial communities between treatment groups. The beta diversity of the calf nasal microbiota was significantly different at day 0 compared to all other timepoints (P = 0.006). The calf nasal beta diversity at day 15 was similar to day 30 (P = 0.38) but significantly different compared to day 60 (P = 0.006). There was no effect of time on altering the alpha (P = 0.60) or beta (P = 0.06) diversity of the dam vaginal microbiota. The calf nasal microbiota was different from the dam vaginal microbiota at all timepoints post-partum, regardless of treatment. At day 15, the alpha and beta diversity of calves was altered compared to day 0, suggestive of a reinoculation timepoint between 0 and 14 days of age. Together, this data contributes to the paucity within beef cattle dam-calf post-partum microbiota literature and provides directionality for future research objectives within this field.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798380119696Subjects--Topical Terms:

1178863
Animal sciences.
Subjects--Index Terms:

BovineIndex Terms--Genre/Form:

554714
Electronic books.

Evaluating the Role of the Bovine Vaginal Microbiome in Neonatal and Maternal Health Outcomes.
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520 $a The dam vaginal microbiota is the first major microbial inoculating community within the neonate. The composition of the dam vaginal microbiota has implications in calf commensal microbiota development. Alterations of the dam microbial community prior to parturition could alter inoculating communities and immune responses in both the dam and calf. Thus, authors aimed to elucidate the microbial community composition of the bovine dam vaginal and calf nasal microbiota post-partum after utilizing betadine lavages (BL). The dam vaginal and calf nasal microbial communities and immune responses were evaluated at 0-, 15-, 30- and 60-day post-partum. Microbiota composition of the dam haircoat, udder, and IgG in the colostrum/calf sera were also evaluated at day 0. Serial BLG prior to parturition did not alter the alpha diversity of the dam-vaginal microbiota but did alter the calf-nasal microbiota at parturition (P = 0.03). Dams receiving BLG prior to calving had increased colostrum IgG concentrations compared to CON dams (P =0.04). These results suggest physiological insults (BLG) prior to parturition led to an increased immune response which altering dam colostrum IgG. Thus, neonatal colostrum consumption could drive immune responses against inoculating bacteria resulting in differing nasal microbial communities between treatment groups. The beta diversity of the calf nasal microbiota was significantly different at day 0 compared to all other timepoints (P = 0.006). The calf nasal beta diversity at day 15 was similar to day 30 (P = 0.38) but significantly different compared to day 60 (P = 0.006). There was no effect of time on altering the alpha (P = 0.60) or beta (P = 0.06) diversity of the dam vaginal microbiota. The calf nasal microbiota was different from the dam vaginal microbiota at all timepoints post-partum, regardless of treatment. At day 15, the alpha and beta diversity of calves was altered compared to day 0, suggestive of a reinoculation timepoint between 0 and 14 days of age. Together, this data contributes to the paucity within beef cattle dam-calf post-partum microbiota literature and provides directionality for future research objectives within this field.
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