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Inhibiting Thioredoxin Reductase for Dual Molecular Targeted and Photodynamic Cancer Therapy.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Inhibiting Thioredoxin Reductase for Dual Molecular Targeted and Photodynamic Cancer Therapy./
Author:	Balgobin, Jessica Dristi.
Description:	1 online resource (77 pages)
Notes:	Source: Masters Abstracts International, Volume: 85-01.
Contained By:	Masters Abstracts International85-01.
Subject:	Organic chemistry. -
Online resource:	click for full text (PQDT)
ISBN:	9798379765569

Inhibiting Thioredoxin Reductase for Dual Molecular Targeted and Photodynamic Cancer Therapy.
Balgobin, Jessica Dristi.

Inhibiting Thioredoxin Reductase for Dual Molecular Targeted and Photodynamic Cancer Therapy. - 1 online resource (77 pages)

Source: Masters Abstracts International, Volume: 85-01.

Thesis (M.Sc.)--University of Toronto (Canada), 2023.

Includes bibliographical references

Conventional cancer treatment is limited by lack of selectivity, limited efficacy towards metastatic cancer and resistive mechanisms acquired by cancer cells. Thus, alternative cancer treatments such as molecular targeted therapy and photodynamic therapy have emerged as promising therapies to combat these issues, although these therapies also present their own limitations. Alternatively, these two types of therapies can be combined for enhanced potency, selectivity and to combat limitations presented by each type of therapy individually. This thesis describes a novel dual therapeutic approach whereby a single small molecule drug, DG-EryB, can irreversibly and covalently inhibit thioredoxin reductase 1 (TrxR1) for molecular targeted therapy, while simultaneously acting as a photosensitizer for photodynamic therapy. This thesis also describes how a photocleavable group can be attached to DG-EryB in a prodrug design for improved pharmacokinetic properties.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798379765569Subjects--Topical Terms:

1148722
Organic chemistry.
Subjects--Index Terms:

InhibitionIndex Terms--Genre/Form:

554714
Electronic books.

Inhibiting Thioredoxin Reductase for Dual Molecular Targeted and Photodynamic Cancer Therapy.
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500 $a Advisor: Beharry, Andrew;Nitz, Mark.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2023.
504 $a Includes bibliographical references
520 $a Conventional cancer treatment is limited by lack of selectivity, limited efficacy towards metastatic cancer and resistive mechanisms acquired by cancer cells. Thus, alternative cancer treatments such as molecular targeted therapy and photodynamic therapy have emerged as promising therapies to combat these issues, although these therapies also present their own limitations. Alternatively, these two types of therapies can be combined for enhanced potency, selectivity and to combat limitations presented by each type of therapy individually. This thesis describes a novel dual therapeutic approach whereby a single small molecule drug, DG-EryB, can irreversibly and covalently inhibit thioredoxin reductase 1 (TrxR1) for molecular targeted therapy, while simultaneously acting as a photosensitizer for photodynamic therapy. This thesis also describes how a photocleavable group can be attached to DG-EryB in a prodrug design for improved pharmacokinetic properties.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2024
538 $a Mode of access: World Wide Web
650 4 $a Organic chemistry. $3 1148722
650 4 $a Biochemistry. $3 582831
650 4 $a Oncology. $3 593951
653 $a Inhibition
653 $a Photocage
653 $a Photodynamic therapy
653 $a Photosensitizer
653 $a Targeted therapy
653 $a Thioredoxin reductase
653 $a Cancer treatment
653 $a DG-EryB
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