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High-Throughput Refractive Index Quantification via Photonic-Crystal Biosensor Microscopy.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	High-Throughput Refractive Index Quantification via Photonic-Crystal Biosensor Microscopy./
Author:	DeLuna, Frank.
Description:	1 online resource (106 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 84-11, Section: B.
Contained By:	Dissertations Abstracts International84-11B.
Subject:	Biomedical engineering. -
Online resource:	click for full text (PQDT)
ISBN:	9798379578145

High-Throughput Refractive Index Quantification via Photonic-Crystal Biosensor Microscopy.
DeLuna, Frank.

High-Throughput Refractive Index Quantification via Photonic-Crystal Biosensor Microscopy. - 1 online resource (106 pages)

Source: Dissertations Abstracts International, Volume: 84-11, Section: B.

Thesis (Ph.D.)--The University of Texas at San Antonio, 2023.

Includes bibliographical references

The work presented in this dissertation describes the development and application of a Photonic-Crystal based biosensor in a Total-Internal-Reflection (PC-TIR) configuration for various biomedical applications. The biosensor utilizes refractive index (RI) as a means of detecting and distinguishing between different cell types and biomolecules. Specifically, we demonstrate the use of the PC-TIR biosensor for the detection of prostate cancer cells and the evaluation of prostate cancer progression using cellular RI as the only contrast parameter. Additionally, we report the development of a high-throughput, multiplexed, antibody-antigen biosensor based on the PC-TIR biosensor for accurate analysis of biomarkers pertinent to traumatic brain injury (TBI). This study highlights the potential of the PC-TIR biosensor as a powerful and versatile platform for various biosensing applications.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798379578145Subjects--Topical Terms:

588770
Biomedical engineering.
Subjects--Index Terms:

Photonic-Crystal biosensorIndex Terms--Genre/Form:

554714
Electronic books.

High-Throughput Refractive Index Quantification via Photonic-Crystal Biosensor Microscopy.
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500 $a Source: Dissertations Abstracts International, Volume: 84-11, Section: B.
500 $a Advisor: Yong Ye, Jing.
502 $a Thesis (Ph.D.)--The University of Texas at San Antonio, 2023.
504 $a Includes bibliographical references
520 $a The work presented in this dissertation describes the development and application of a Photonic-Crystal based biosensor in a Total-Internal-Reflection (PC-TIR) configuration for various biomedical applications. The biosensor utilizes refractive index (RI) as a means of detecting and distinguishing between different cell types and biomolecules. Specifically, we demonstrate the use of the PC-TIR biosensor for the detection of prostate cancer cells and the evaluation of prostate cancer progression using cellular RI as the only contrast parameter. Additionally, we report the development of a high-throughput, multiplexed, antibody-antigen biosensor based on the PC-TIR biosensor for accurate analysis of biomarkers pertinent to traumatic brain injury (TBI). This study highlights the potential of the PC-TIR biosensor as a powerful and versatile platform for various biosensing applications.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2024
538 $a Mode of access: World Wide Web
650 4 $a Biomedical engineering. $3 588770
650 4 $a Oncology. $3 593951
650 4 $a Analytical chemistry. $3 1182118
653 $a Photonic-Crystal biosensor
653 $a Biomedical applications
653 $a Traumatic brain injury
653 $a Cancer cells
655 7 $a Electronic books. $2 local $3 554714
690 $a 0541
690 $a 0486
690 $a 0992
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710 2 $a The University of Texas at San Antonio. $b Biomedical Engineering. $3 1191143
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