國立虎尾科技大學 |

Computational Study of Receptor Mediated Endocytosis for Functional Nanoparticle Transport.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Computational Study of Receptor Mediated Endocytosis for Functional Nanoparticle Transport./
Author:	Billah, Md. Muhtasim.
Description:	1 online resource (151 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-03, Section: B.
Contained By:	Dissertations Abstracts International85-03B.
Subject:	Mechanical engineering. -
Online resource:	click for full text (PQDT)
ISBN:	9798380378444

Computational Study of Receptor Mediated Endocytosis for Functional Nanoparticle Transport.
Billah, Md. Muhtasim.

Computational Study of Receptor Mediated Endocytosis for Functional Nanoparticle Transport. - 1 online resource (151 pages)

Source: Dissertations Abstracts International, Volume: 85-03, Section: B.

Thesis (Ph.D.)--Washington State University, 2023.

Includes bibliographical references

Receptor mediated endocytosis (RME) is a frequently observed process used by bioparticles such as viruses, bacteria, and therapeutic drugs to enter cells. Traditionally, it was assumed that RME was always facilitated by the coat protein clathrin, but recent research has shown that there are also clathrin-independent RME pathways. These pathways are crucial for understanding how viruses, bacteria, and drugs enter cells as well as for delivering drugs to the affected cells. However, RME is a complex and multi-stage process that involves intricate interactions between the particles and cellular components, and therefore extensive research is needed. Numerous computational models have been proposed to augment experimental findings, but a comprehensive understanding of endocytic pathways remains challenging and elusive.This study utilized a stochastic model based on the Metropolis Monte Carlo method to investigate the internalization of nanoparticles into cells. The model takes into account ligand-receptor interactions, the formation of clathrin-coated pits, and membrane deformation during receptor-mediated endocytosis (RME). The model was used to examine the impact of critical physiochemical parameters, including the flexural rigidity and length of receptors, and the reaction cutoff distance, on both clathrin-dependent and clathrin-independent RME.Furthermore, while spherical nanoparticles are currently the most commonly used nanocarriers in laboratory and clinical settings, advances in nanofabrication techniques have made it possible to create nanoparticles of various shapes that closely resemble viruses and bacteria found in nature. The development of nonspherical nanoparticles holds great promise for future drug delivery systems. Therefore, we expanded our model to explore the design considerations and overall endocytosis efficiency of rod-shaped nanoparticles in comparison to their spherical counterparts.Finally, our simulation of the endocytosis process highlighted the significant impact of various physical, mechanical, and chemical factors, and a comprehensive study of these parameters can be an extensive undertaking. Therefore, incorporating more sophisticated computational algorithms during the simulation, or for post-processing the simulation results, holds promise. To explore this direction in future research, we have demonstrated a novel physics-based machine learning approach on a classic heat transfer problem in this study.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798380378444Subjects--Topical Terms:

557493
Mechanical engineering.
Subjects--Index Terms:

Clathrin-independent endocytosisIndex Terms--Genre/Form:

554714
Electronic books.

Computational Study of Receptor Mediated Endocytosis for Functional Nanoparticle Transport.
LDR:03912ntm a22004097 4500 001 1143609
005 20240517104611.5
006 m o d
007 cr mn ---uuuuu
008 250605s2023 xx obm 000 0 eng d
020 $a 9798380378444
035 $a (MiAaPQ)AAI30524666
035 $a AAI30524666
040 $a MiAaPQ $b eng $c MiAaPQ $d NTU
100 1 $a Billah, Md. Muhtasim. $3 1468347
245 1 0 $a Computational Study of Receptor Mediated Endocytosis for Functional Nanoparticle Transport.
264 0 $c 2023
300 $a 1 online resource (151 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 85-03, Section: B.
500 $a Advisor: Liu, Jin.
502 $a Thesis (Ph.D.)--Washington State University, 2023.
504 $a Includes bibliographical references
520 $a Receptor mediated endocytosis (RME) is a frequently observed process used by bioparticles such as viruses, bacteria, and therapeutic drugs to enter cells. Traditionally, it was assumed that RME was always facilitated by the coat protein clathrin, but recent research has shown that there are also clathrin-independent RME pathways. These pathways are crucial for understanding how viruses, bacteria, and drugs enter cells as well as for delivering drugs to the affected cells. However, RME is a complex and multi-stage process that involves intricate interactions between the particles and cellular components, and therefore extensive research is needed. Numerous computational models have been proposed to augment experimental findings, but a comprehensive understanding of endocytic pathways remains challenging and elusive.This study utilized a stochastic model based on the Metropolis Monte Carlo method to investigate the internalization of nanoparticles into cells. The model takes into account ligand-receptor interactions, the formation of clathrin-coated pits, and membrane deformation during receptor-mediated endocytosis (RME). The model was used to examine the impact of critical physiochemical parameters, including the flexural rigidity and length of receptors, and the reaction cutoff distance, on both clathrin-dependent and clathrin-independent RME.Furthermore, while spherical nanoparticles are currently the most commonly used nanocarriers in laboratory and clinical settings, advances in nanofabrication techniques have made it possible to create nanoparticles of various shapes that closely resemble viruses and bacteria found in nature. The development of nonspherical nanoparticles holds great promise for future drug delivery systems. Therefore, we expanded our model to explore the design considerations and overall endocytosis efficiency of rod-shaped nanoparticles in comparison to their spherical counterparts.Finally, our simulation of the endocytosis process highlighted the significant impact of various physical, mechanical, and chemical factors, and a comprehensive study of these parameters can be an extensive undertaking. Therefore, incorporating more sophisticated computational algorithms during the simulation, or for post-processing the simulation results, holds promise. To explore this direction in future research, we have demonstrated a novel physics-based machine learning approach on a classic heat transfer problem in this study.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2024
538 $a Mode of access: World Wide Web
650 4 $a Mechanical engineering. $3 557493
650 4 $a Statistics. $3 556824
650 4 $a Materials science. $3 557839
650 4 $a Nanotechnology. $3 557660
653 $a Clathrin-independent endocytosis
653 $a Inverse problems
653 $a Machine learning
653 $a Receptor mediated endocytosis
653 $a Nanoparticles
655 7 $a Electronic books. $2 local $3 554714
690 $a 0548
690 $a 0463
690 $a 0794
690 $a 0652
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a Washington State University. $b School of Mechanical and Materials Engineering. $3 1372538
773 0 $t Dissertations Abstracts International $g 85-03B.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30524666 $z click for full text (PQDT)