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Design, Fabrication, and Characterization of Melt Electrowriting-Enabled 3D Structured Materials.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Design, Fabrication, and Characterization of Melt Electrowriting-Enabled 3D Structured Materials./
Author:	Zhang, Fucheng.
Description:	1 online resource (198 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-04, Section: B.
Contained By:	Dissertations Abstracts International85-04B.
Subject:	Mechanical engineering. -
Online resource:	click for full text (PQDT)
ISBN:	9798380581158

Design, Fabrication, and Characterization of Melt Electrowriting-Enabled 3D Structured Materials.
Zhang, Fucheng.

Design, Fabrication, and Characterization of Melt Electrowriting-Enabled 3D Structured Materials. - 1 online resource (198 pages)

Source: Dissertations Abstracts International, Volume: 85-04, Section: B.

Thesis (Ph.D.)--Stevens Institute of Technology, 2023.

Includes bibliographical references

A melt electrospinning writing (MEW) system that additively processes molten polymers has emerged as a reliable method to fabricate high-fidelity 3D structured materials, specifically fibrous tissue scaffolds for the investigation of biological performance outcomes as a function of microscale structural features. This dissertation aims to address two research challenges that represent bottlenecks to broadening the applications for MEW as a reliable additive manufacturing process.Firstly, the current state-of-art toolpath design of scaffolds is limited owing to the lack of a generalized model for the creation of heterogeneous scaffolds. To address this bottleneck, MEW is implemented to leverage customized toolpath designs to fabricate various scaffold architectures. To achieve this, two toolpath design models are proposed for the design of customizable planar and tubular scaffolds. These two models enable the heterogeneous scaffold design by prescribing analytical scaffold design parameters. The heterogeneous planar scaffolds can possess at most three different morphologies, which can be analyzed by a matrix analysis model. Furthermore, the tubular scaffolds can possess multi-sided pores (pore side number ≥ 4) with heterogeneous distribution of various pore morphologies along the axial direction. Based on the mechanical testing of the tubular scaffolds, the elastic modulus is found to be a function of the scaffold design parameters. These fabricated spatially heterogeneous scaffolds with well-defined, non-uniform pore attributes can serve as biomimetic, multiplexed platforms for biological investigations including musculoskeletal tissue that is typified by heterogeneity in the mechanical properties.Secondly, deterioration in the MEW printing accuracy is observed to coincide with the occurrence of fiber deviation phenomena during the scaffold fabrication process. Herein, an efficient universal index (Ip), along with an evaluation protocol, is advanced to evaluate the printing accuracy of MEW. Specifically, the key scaffold design parameters (fiber diameter, inter-fiber distance, and layer number) are observed to affect the value of Ip significantly. Furthermore, the printing sequence can affect the printing accuracy when fabricating scaffolds with different inter-fiber distances along different printing directions. This dependency is most apparent when qualifying loosely structured scaffolds marked by inter-layer gaps. Lastly, residual charge densities entrapped in the scaffolds are measured, thereby furnishing mechanistic insights into the effects of charge on printing accuracy. Therefore, the evaluation protocol advanced herein will enable the qualification of various methodologies to reduce the residual charge densities, yielding a decrease in the observed fiber deviation phenomena with enhanced printing accuracy.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798380581158Subjects--Topical Terms:

557493
Mechanical engineering.
Subjects--Index Terms:

Melt electrospinning writingIndex Terms--Genre/Form:

554714
Electronic books.

Design, Fabrication, and Characterization of Melt Electrowriting-Enabled 3D Structured Materials.
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520 $a A melt electrospinning writing (MEW) system that additively processes molten polymers has emerged as a reliable method to fabricate high-fidelity 3D structured materials, specifically fibrous tissue scaffolds for the investigation of biological performance outcomes as a function of microscale structural features. This dissertation aims to address two research challenges that represent bottlenecks to broadening the applications for MEW as a reliable additive manufacturing process.Firstly, the current state-of-art toolpath design of scaffolds is limited owing to the lack of a generalized model for the creation of heterogeneous scaffolds. To address this bottleneck, MEW is implemented to leverage customized toolpath designs to fabricate various scaffold architectures. To achieve this, two toolpath design models are proposed for the design of customizable planar and tubular scaffolds. These two models enable the heterogeneous scaffold design by prescribing analytical scaffold design parameters. The heterogeneous planar scaffolds can possess at most three different morphologies, which can be analyzed by a matrix analysis model. Furthermore, the tubular scaffolds can possess multi-sided pores (pore side number ≥ 4) with heterogeneous distribution of various pore morphologies along the axial direction. Based on the mechanical testing of the tubular scaffolds, the elastic modulus is found to be a function of the scaffold design parameters. These fabricated spatially heterogeneous scaffolds with well-defined, non-uniform pore attributes can serve as biomimetic, multiplexed platforms for biological investigations including musculoskeletal tissue that is typified by heterogeneity in the mechanical properties.Secondly, deterioration in the MEW printing accuracy is observed to coincide with the occurrence of fiber deviation phenomena during the scaffold fabrication process. Herein, an efficient universal index (Ip), along with an evaluation protocol, is advanced to evaluate the printing accuracy of MEW. Specifically, the key scaffold design parameters (fiber diameter, inter-fiber distance, and layer number) are observed to affect the value of Ip significantly. Furthermore, the printing sequence can affect the printing accuracy when fabricating scaffolds with different inter-fiber distances along different printing directions. This dependency is most apparent when qualifying loosely structured scaffolds marked by inter-layer gaps. Lastly, residual charge densities entrapped in the scaffolds are measured, thereby furnishing mechanistic insights into the effects of charge on printing accuracy. Therefore, the evaluation protocol advanced herein will enable the qualification of various methodologies to reduce the residual charge densities, yielding a decrease in the observed fiber deviation phenomena with enhanced printing accuracy.
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