國立虎尾科技大學 |

Exploring Relationships between Peripheral Inflammation and Resting-State Functional Connectivity in Two Chronic Inflammation-Prone Samples.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Exploring Relationships between Peripheral Inflammation and Resting-State Functional Connectivity in Two Chronic Inflammation-Prone Samples./
Author:	YorkWilliams, Sophie L.
Description:	1 online resource (73 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 83-03, Section: B.
Contained By:	Dissertations Abstracts International83-03B.
Subject:	Clinical psychology. -
Online resource:	click for full text (PQDT)
ISBN:	9798538131549

Exploring Relationships between Peripheral Inflammation and Resting-State Functional Connectivity in Two Chronic Inflammation-Prone Samples.
YorkWilliams, Sophie L.

Exploring Relationships between Peripheral Inflammation and Resting-State Functional Connectivity in Two Chronic Inflammation-Prone Samples. - 1 online resource (73 pages)

Source: Dissertations Abstracts International, Volume: 83-03, Section: B.

Thesis (Ph.D.)--University of Colorado at Boulder, 2021.

Includes bibliographical references

Alcohol use disorder (AUD) and age-related executive dysfunction are pervasive and neurobiologically complex conditions with large public health burdens. While research continues to elucidate the mechanisms underlying their development and maintenance, both conditions are associated with chronic peripheral inflammation and with functional brain changes in the default mode and frontoparietal control networks (DMN and FPCN). Whether these two phenomena are connected has not been adequately explored in either AUD or age-related executive decline. The present study examines whether this link exists in a sample of adults with AUD, and in a sample of sedentary older adults, using cross-sectional data from two parent studies. Namely, it examines whether region-to-region functional connectivity within the DMN and FPCN are associated with peripheral inflammation as measured by plasma levels of key inflammatory proteins (interleukin 1-beta, interleukin 6, and tumor necrosis factor alpha). In the AUD sample, connectivity changes within both DMN and FPCN occurred as peripheral inflammation increased, and results remained after controlling for participant age. In the sedentary older-adult sample, neuroimaging results did not survive correction for false discovery rate, but DMN and FPCN associations with peripheral inflammation were observed at uncorrected thresholds. Results provide support for continued exploration of aging- and AUD-related changes in neuroimmune communication. The study's methodological considerations, clinical significance, and future directions are explored.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798538131549Subjects--Topical Terms:

649607
Clinical psychology.
Subjects--Index Terms:

Age-related cognitive declineIndex Terms--Genre/Form:

554714
Electronic books.

Exploring Relationships between Peripheral Inflammation and Resting-State Functional Connectivity in Two Chronic Inflammation-Prone Samples.
LDR:03232ntm a22004457 4500 001 1145442
005 20240624103652.5
006 m o d
007 cr bn ---uuuuu
008 250605s2021 xx obm 000 0 eng d
020 $a 9798538131549
035 $a (MiAaPQ)AAI28651857
035 $a AAI28651857
040 $a MiAaPQ $b eng $c MiAaPQ $d NTU
100 1 $a YorkWilliams, Sophie L. $3 1437666
245 1 0 $a Exploring Relationships between Peripheral Inflammation and Resting-State Functional Connectivity in Two Chronic Inflammation-Prone Samples.
264 0 $c 2021
300 $a 1 online resource (73 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 83-03, Section: B.
500 $a Includes supplementary digital materials.
500 $a Advisor: Hutchison, Kent;Bryan, Angela.
502 $a Thesis (Ph.D.)--University of Colorado at Boulder, 2021.
504 $a Includes bibliographical references
520 $a Alcohol use disorder (AUD) and age-related executive dysfunction are pervasive and neurobiologically complex conditions with large public health burdens. While research continues to elucidate the mechanisms underlying their development and maintenance, both conditions are associated with chronic peripheral inflammation and with functional brain changes in the default mode and frontoparietal control networks (DMN and FPCN). Whether these two phenomena are connected has not been adequately explored in either AUD or age-related executive decline. The present study examines whether this link exists in a sample of adults with AUD, and in a sample of sedentary older adults, using cross-sectional data from two parent studies. Namely, it examines whether region-to-region functional connectivity within the DMN and FPCN are associated with peripheral inflammation as measured by plasma levels of key inflammatory proteins (interleukin 1-beta, interleukin 6, and tumor necrosis factor alpha). In the AUD sample, connectivity changes within both DMN and FPCN occurred as peripheral inflammation increased, and results remained after controlling for participant age. In the sedentary older-adult sample, neuroimaging results did not survive correction for false discovery rate, but DMN and FPCN associations with peripheral inflammation were observed at uncorrected thresholds. Results provide support for continued exploration of aging- and AUD-related changes in neuroimmune communication. The study's methodological considerations, clinical significance, and future directions are explored.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2024
538 $a Mode of access: World Wide Web
650 4 $a Clinical psychology. $3 649607
650 4 $a Neurosciences. $3 593561
650 4 $a Exercise. $3 583899
650 4 $a Behavior. $3 582559
650 4 $a Pathogens. $3 1413560
650 4 $a Physical fitness. $3 583773
650 4 $a Memory. $3 555749
650 4 $a Mental disorders. $3 647312
650 4 $a Metabolism. $3 581368
650 4 $a Older people. $3 554842
650 4 $a Cognitive ability. $3 1372497
650 4 $a Medical imaging. $3 1180167
650 4 $a Alzheimers disease. $3 1413648
650 4 $a Blood-brain barrier. $3 582010
650 4 $a Addictions. $3 1437668
650 4 $a Age. $3 1116564
650 4 $a Hypotheses. $3 1372657
650 4 $a Aging. $3 559847
650 4 $a Immune system. $3 679775
650 4 $a Magnetic resonance imaging. $3 644374
650 4 $a Alcohol use. $3 935890
650 4 $a Cardiovascular disease. $3 1437669
650 4 $a Nervous system. $3 678471
650 4 $a Mental health. $3 564038
650 4 $a Addictive behaviors. $3 1437662
650 4 $a Emotional disorders. $3 1437670
650 4 $a Adults. $3 1372489
653 $a Age-related cognitive decline
653 $a Alcohol use disorder
653 $a Executive function
653 $a Intrinsically Connected Networks
653 $a Peripheral inflammation
653 $a Resting-state fMRI
655 7 $a Electronic books. $2 local $3 554714
690 $a 0622
690 $a 0317
690 $a 0493
690 $a 0347
690 $a 0574
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a University of Colorado at Boulder. $b Psychology. $3 1437667
773 0 $t Dissertations Abstracts International $g 83-03B.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28651857 $z click for full text (PQDT)