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Exploring Relationships between Peripheral Inflammation and Resting-State Functional Connectivity in Two Chronic Inflammation-Prone Samples.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	Exploring Relationships between Peripheral Inflammation and Resting-State Functional Connectivity in Two Chronic Inflammation-Prone Samples./
作者:	YorkWilliams, Sophie L.
面頁冊數:	1 online resource (73 pages)
附註:	Source: Dissertations Abstracts International, Volume: 83-03, Section: B.
Contained By:	Dissertations Abstracts International83-03B.
標題:	Adults. -
電子資源:	click for full text (PQDT)
ISBN:	9798538131549

Exploring Relationships between Peripheral Inflammation and Resting-State Functional Connectivity in Two Chronic Inflammation-Prone Samples.
YorkWilliams, Sophie L.

Exploring Relationships between Peripheral Inflammation and Resting-State Functional Connectivity in Two Chronic Inflammation-Prone Samples. - 1 online resource (73 pages)

Source: Dissertations Abstracts International, Volume: 83-03, Section: B.

Thesis (Ph.D.)--University of Colorado at Boulder, 2021.

Includes bibliographical references

Alcohol use disorder (AUD) and age-related executive dysfunction are pervasive and neurobiologically complex conditions with large public health burdens. While research continues to elucidate the mechanisms underlying their development and maintenance, both conditions are associated with chronic peripheral inflammation and with functional brain changes in the default mode and frontoparietal control networks (DMN and FPCN). Whether these two phenomena are connected has not been adequately explored in either AUD or age-related executive decline. The present study examines whether this link exists in a sample of adults with AUD, and in a sample of sedentary older adults, using cross-sectional data from two parent studies. Namely, it examines whether region-to-region functional connectivity within the DMN and FPCN are associated with peripheral inflammation as measured by plasma levels of key inflammatory proteins (interleukin 1-beta, interleukin 6, and tumor necrosis factor alpha). In the AUD sample, connectivity changes within both DMN and FPCN occurred as peripheral inflammation increased, and results remained after controlling for participant age. In the sedentary older-adult sample, neuroimaging results did not survive correction for false discovery rate, but DMN and FPCN associations with peripheral inflammation were observed at uncorrected thresholds. Results provide support for continued exploration of aging- and AUD-related changes in neuroimmune communication. The study's methodological considerations, clinical significance, and future directions are explored.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798538131549Subjects--Topical Terms:

1372489
Adults.
Subjects--Index Terms:

Age-related cognitive declineIndex Terms--Genre/Form:

554714
Electronic books.

Exploring Relationships between Peripheral Inflammation and Resting-State Functional Connectivity in Two Chronic Inflammation-Prone Samples.
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