國立虎尾科技大學 |

Optimisation Methods for Advanced Gamma Knife Radiosurgery Treatment.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	Optimisation Methods for Advanced Gamma Knife Radiosurgery Treatment./
作者:	Tham, Benjamin Zhen-Hong.
面頁冊數:	1 online resource (87 pages)
附註:	Source: Dissertations Abstracts International, Volume: 85-10, Section: B.
Contained By:	Dissertations Abstracts International85-10B.
標題:	Biomedical engineering. -
電子資源:	click for full text (PQDT)
ISBN:	9798382192611

Optimisation Methods for Advanced Gamma Knife Radiosurgery Treatment.
Tham, Benjamin Zhen-Hong.

Optimisation Methods for Advanced Gamma Knife Radiosurgery Treatment. - 1 online resource (87 pages)

Source: Dissertations Abstracts International, Volume: 85-10, Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2024.

Includes bibliographical references

Stereotactic radiosurgery is a high-precision mode of radiotherapy that delivers high dose radiation to brain tumours in one or a few sessions. Recent developments in Gamma Knife® radiosurgery machines (Elekta AB, Stockholm, Sweden) have increased treatment precision and functionality, allowing the exploration of new and promising treatment methods. This thesis works to bring two such methods towards clinical implementation. One method is dose painting, which leverages tumour heterogeneity to deliver variable prescribed doses to different parts of a tumour, potentially improving tumour control while reducing unnecessary dose to healthy tissue. A second method is dynamic treatment, which delivers radiation while moving the treatment isocentre, potentially reducing treatment time while improving dose conformity and homogeneity.For dose painting, we first developed a set of metrics to allow the assessment of dose painting radiosurgery plan quality, meeting both clinical radiosurgery needs while being calculated with nonuniform dose painting prescriptions. We then used treatment planning optimisation and automated isocentre placement to generate treatment plans for dose painting prescriptions, allowing us to examine the quality of dose painting Gamma Knife® plans achievable through optimisation, quantify how dose painting prescription methods affect plan quality, and explore how automated isocentre placement affects plan quality.For dynamic treatment, we conducted physical experiments to validate the real-world feasibility of dynamic Gamma Knife® treatment. The experiments allowed us to address assumptions made with previous computational studies (such as the validity of treating a continuous path as discretised points), investigate uncertainties in translating computed plans to actual dynamic treatment, and determine ideal treatment planning parameters (such as interval distance for the discretisation of movement paths, collimator change limitations, and minimum isocentre treatment times).Through our work, both dose painting and dynamic treatment are better investigated as potential treatment methods for the current Gamma Knife® radiosurgery machines.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798382192611Subjects--Topical Terms:

588770
Biomedical engineering.
Subjects--Index Terms:

Gamma KnifeIndex Terms--Genre/Form:

554714
Electronic books.

Optimisation Methods for Advanced Gamma Knife Radiosurgery Treatment.
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