國立虎尾科技大學 |

Nanodiamond mediated therapies for prostate cancer.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Nanodiamond mediated therapies for prostate cancer./
Author:	Salaam, Amanee D.
Description:	1 online resource (128 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 75-12, Section: B.
Contained By:	Dissertations Abstracts International75-12B.
Subject:	Oncology. -
Online resource:	click for full text (PQDT)
ISBN:	9781303868528

Nanodiamond mediated therapies for prostate cancer.
Salaam, Amanee D.

Nanodiamond mediated therapies for prostate cancer. - 1 online resource (128 pages)

Source: Dissertations Abstracts International, Volume: 75-12, Section: B.

Thesis (Ph.D.)--The University of Alabama at Birmingham, 2014.

Includes bibliographical references

Enhancing therapeutic efficacy is essential for successful treatment of chemoresistant cancers such as metastatic hormone-refractory prostate cancer. Current chemotherapy regimens are plagued with issues such as toxicity, low bioavailability, and lack of specificity. To combat these issues, the feasibility of using nanodiamond particles (ND) to enhance the therapeutic efficacy of doxorubicin and resveratrol was investigated. The enhancement of chemotherapy using NDs was evaluated with three unique approaches: (1) drug mediation, (2) combination therapy, and (3) targeted drug delivery. The ND mediated doxorubicin system achieved a 50% improvement in therapeutic efficacy with over 60% cell death. The ND resveratrol combination therapy improved the efficacy of resveratrol by 40%, enhancing its typically low bioavailability. To facilitate targeting and further enhance the efficacy of doxorubicin, NDs were conjugated with the Asp-Gly-Glu-Ala (DGEA) peptide, which interacts with integrins over-expressed in metastatic prostate cancers, α2β1. The resulting ND-DGEA doxorubicin targeted drug delivery system produced a 4 fold increase in efficacy with low drug doses. The findings from each component of the work confirmed that NDs are capable of enhancing therapeutic efficacy. The results from these studies are promising as they suggest that drug delivery with NDs provides a novel approach for decreasing toxicity and drug doses of traditional chemotherapy.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9781303868528Subjects--Topical Terms:

593951
Oncology.
Subjects--Index Terms:

Dgea peptideIndex Terms--Genre/Form:

554714
Electronic books.

Nanodiamond mediated therapies for prostate cancer.
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500 $a Source: Dissertations Abstracts International, Volume: 75-12, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Dean, Derrick.
502 $a Thesis (Ph.D.)--The University of Alabama at Birmingham, 2014.
504 $a Includes bibliographical references
520 $a Enhancing therapeutic efficacy is essential for successful treatment of chemoresistant cancers such as metastatic hormone-refractory prostate cancer. Current chemotherapy regimens are plagued with issues such as toxicity, low bioavailability, and lack of specificity. To combat these issues, the feasibility of using nanodiamond particles (ND) to enhance the therapeutic efficacy of doxorubicin and resveratrol was investigated. The enhancement of chemotherapy using NDs was evaluated with three unique approaches: (1) drug mediation, (2) combination therapy, and (3) targeted drug delivery. The ND mediated doxorubicin system achieved a 50% improvement in therapeutic efficacy with over 60% cell death. The ND resveratrol combination therapy improved the efficacy of resveratrol by 40%, enhancing its typically low bioavailability. To facilitate targeting and further enhance the efficacy of doxorubicin, NDs were conjugated with the Asp-Gly-Glu-Ala (DGEA) peptide, which interacts with integrins over-expressed in metastatic prostate cancers, α2β1. The resulting ND-DGEA doxorubicin targeted drug delivery system produced a 4 fold increase in efficacy with low drug doses. The findings from each component of the work confirmed that NDs are capable of enhancing therapeutic efficacy. The results from these studies are promising as they suggest that drug delivery with NDs provides a novel approach for decreasing toxicity and drug doses of traditional chemotherapy.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2024
538 $a Mode of access: World Wide Web
650 4 $a Oncology. $3 593951
650 4 $a Nanotechnology. $3 557660
650 4 $a Biomedical engineering. $3 588770
650 4 $a Engineering. $3 561152
653 $a Dgea peptide
653 $a Doxorubicin
653 $a Nanodiamond
653 $a Prostate cancer
653 $a Resveratrol
653 $a Targeted drug delivery
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690 $a 0541
690 $a 0652
690 $a 0992
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