語系:
繁體中文
English
說明(常見問題)
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Structure-Function Coupling in Human Brain Networks.
紀錄類型:
書目-語言資料,手稿 : Monograph/item
正題名/作者:
Structure-Function Coupling in Human Brain Networks./
作者:
Fotiadis, Panagiotis.
面頁冊數:
1 online resource (565 pages)
附註:
Source: Dissertations Abstracts International, Volume: 85-08, Section: B.
Contained By:
Dissertations Abstracts International85-08B.
標題:
Neurosciences. -
電子資源:
click for full text (PQDT)
ISBN:
9798381510065
Structure-Function Coupling in Human Brain Networks.
Fotiadis, Panagiotis.
Structure-Function Coupling in Human Brain Networks.
- 1 online resource (565 pages)
Source: Dissertations Abstracts International, Volume: 85-08, Section: B.
Thesis (Ph.D.)--University of Pennsylvania, 2023.
Includes bibliographical references
The human brain is a complex network; an intricately woven tapestry of neuronal and non-neuronal cells in constant communication with each other. Precisely how the anatomical wiring of the human brain gives rise to a repertoire of complex functions remains incompletely understood. To elucidate this intricate mapping, we employ tools from network neuroscience and control theory: the former allows us to quantify the structural and functional connectivity patterns across different brain regions, while the latter tells us how to drive the brain from an initial pattern of functional activation to a target pattern, using external input. First, to understand how flexible cognition emerges from the underlying anatomical connectivity of the brain, we analyze neuroimaging data acquired from humans and macaque monkeys and show that flexible cognition depends on the distribution of the underlying anatomical projections and the energetic costs required to switch between different patterns of functional activation. Secondly, to address how the relationship between structure and function varies across different brain regions and among individuals, we introduce the concept of structure-function coupling, a metric that quantifies how strongly a brain region's functional expression patterns reflect the underlying structural connectivity. We review studies assessing the heterogeneous expression of structure-function coupling across brain regions, individuals, cognitive tasks, and over time, and its role in fostering flexible cognition. From a clinical perspective, we further collate studies showcasing how structure-function coupling becomes aberrant in the presence of neurological and psychiatric disorders. To investigate why structure-function coupling changes across the aforementioned dimensions, we draw insight from the fields of neurobiology and computational neuroscience. We then empirically demonstrate how different neurobiological properties operating at different timescales synergistically shape structure-function coupling across the cortex, in a region-dependent manner. Lastly, we investigate how the interplay between structure and function changes as humans transition between wakefulness and unconsciousness, and demonstrate that induction to and emergence from anesthetically-induced unconsciousness are characterized by widespread connectivity and hemodynamic changes. Collectively, this work deepens our understanding on how the brain's anatomical architecture shapes its complex functional expression in health, in the presence of neuropsychiatric disorders, and across conscious-unconscious transitions.
Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024
Mode of access: World Wide Web
ISBN: 9798381510065Subjects--Topical Terms:
593561
Neurosciences.
Subjects--Index Terms:
ConsciousnessIndex Terms--Genre/Form:
554714
Electronic books.
Structure-Function Coupling in Human Brain Networks.
LDR
:04029ntm a22004097 4500
001
1147992
005
20240916065958.5
006
m o d
007
cr bn ---uuuuu
008
250605s2023 xx obm 000 0 eng d
020
$a
9798381510065
035
$a
(MiAaPQ)AAI30695980
035
$a
AAI30695980
040
$a
MiAaPQ
$b
eng
$c
MiAaPQ
$d
NTU
100
1
$a
Fotiadis, Panagiotis.
$3
1473850
245
1 0
$a
Structure-Function Coupling in Human Brain Networks.
264
0
$c
2023
300
$a
1 online resource (565 pages)
336
$a
text
$b
txt
$2
rdacontent
337
$a
computer
$b
c
$2
rdamedia
338
$a
online resource
$b
cr
$2
rdacarrier
500
$a
Source: Dissertations Abstracts International, Volume: 85-08, Section: B.
500
$a
Advisor: Bassett, Dani S.
502
$a
Thesis (Ph.D.)--University of Pennsylvania, 2023.
504
$a
Includes bibliographical references
520
$a
The human brain is a complex network; an intricately woven tapestry of neuronal and non-neuronal cells in constant communication with each other. Precisely how the anatomical wiring of the human brain gives rise to a repertoire of complex functions remains incompletely understood. To elucidate this intricate mapping, we employ tools from network neuroscience and control theory: the former allows us to quantify the structural and functional connectivity patterns across different brain regions, while the latter tells us how to drive the brain from an initial pattern of functional activation to a target pattern, using external input. First, to understand how flexible cognition emerges from the underlying anatomical connectivity of the brain, we analyze neuroimaging data acquired from humans and macaque monkeys and show that flexible cognition depends on the distribution of the underlying anatomical projections and the energetic costs required to switch between different patterns of functional activation. Secondly, to address how the relationship between structure and function varies across different brain regions and among individuals, we introduce the concept of structure-function coupling, a metric that quantifies how strongly a brain region's functional expression patterns reflect the underlying structural connectivity. We review studies assessing the heterogeneous expression of structure-function coupling across brain regions, individuals, cognitive tasks, and over time, and its role in fostering flexible cognition. From a clinical perspective, we further collate studies showcasing how structure-function coupling becomes aberrant in the presence of neurological and psychiatric disorders. To investigate why structure-function coupling changes across the aforementioned dimensions, we draw insight from the fields of neurobiology and computational neuroscience. We then empirically demonstrate how different neurobiological properties operating at different timescales synergistically shape structure-function coupling across the cortex, in a region-dependent manner. Lastly, we investigate how the interplay between structure and function changes as humans transition between wakefulness and unconsciousness, and demonstrate that induction to and emergence from anesthetically-induced unconsciousness are characterized by widespread connectivity and hemodynamic changes. Collectively, this work deepens our understanding on how the brain's anatomical architecture shapes its complex functional expression in health, in the presence of neuropsychiatric disorders, and across conscious-unconscious transitions.
533
$a
Electronic reproduction.
$b
Ann Arbor, Mich. :
$c
ProQuest,
$d
2024
538
$a
Mode of access: World Wide Web
650
4
$a
Neurosciences.
$3
593561
650
4
$a
Bioengineering.
$3
598252
650
4
$a
Physiology.
$3
673386
653
$a
Consciousness
653
$a
Control theory
653
$a
Hemodynamics
653
$a
Network neuroscience
653
$a
Neuroimaging
653
$a
Structure-function coupling
655
7
$a
Electronic books.
$2
local
$3
554714
690
$a
0317
690
$a
0202
690
$a
0719
710
2
$a
ProQuest Information and Learning Co.
$3
1178819
710
2
$a
University of Pennsylvania.
$b
Neuroscience.
$3
1190675
773
0
$t
Dissertations Abstracts International
$g
85-08B.
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30695980
$z
click for full text (PQDT)
筆 0 讀者評論
多媒體
評論
新增評論
分享你的心得
Export
取書館別
處理中
...
變更密碼[密碼必須為2種組合(英文和數字)及長度為10碼以上]
登入