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Cell toxicity and uptake of RRR-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) by various cell lines in vitro.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	Cell toxicity and uptake of RRR-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) by various cell lines in vitro./
作者:	Komguem Kamga, Christelle.
面頁冊數:	1 online resource (78 pages)
附註:	Source: Masters Abstracts International, Volume: 70-05.
Contained By:	Masters Abstracts International70-05.
標題:	Analytical chemistry. -
電子資源:	click for full text (PQDT)
ISBN:	9780549758068

Cell toxicity and uptake of RRR-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) by various cell lines in vitro.
Komguem Kamga, Christelle.

Cell toxicity and uptake of RRR-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) by various cell lines in vitro. - 1 online resource (78 pages)

Source: Masters Abstracts International, Volume: 70-05.

Thesis (M.Sc.)--East Tennessee State University, 2005.

Includes bibliographical references

This research focused on investigating and comparing the cytotoxicity and cellular uptake of RRR-alpha-tocopheryl polyethylene glycol succinate (TPGS) with that of alpha-tocopheryl succinate (α-TS). Both TPGS and α-TS are water-soluble forms of vitamin E with important clinical applications. Cytotoxicity assays with RAW 264.7 and LNCaP cells incubated overnight with TPGS or α-TS at concentrations ≥ 12.4 μM suggest that α-TS is more cytotoxic than TPGS. Macrophages were found to be more sensitive than LNCaP cells when treated with similar concentrations of α-TS. For both cell lines, most of the TPGS or α-TS taken up remained esterified after 24 hours. Our results suggest that cell death was due to TPGS and/or α-TS and not alpha-tocopherol. A para-hydroxyanilide of α-TS (p-HATS) that could be used to distinguish between cellular TPGS and α-TS was studied. It was found that p-HATS can be detected electrochemically and that it is hydrolyzed to α-TOH.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9780549758068Subjects--Topical Terms:

1182118
Analytical chemistry.
Index Terms--Genre/Form:

554714
Electronic books.

Cell toxicity and uptake of RRR-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) by various cell lines in vitro.
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245 1 0 $a Cell toxicity and uptake of RRR-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) by various cell lines in vitro.
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500 $a Source: Masters Abstracts International, Volume: 70-05.
500 $a Publisher info.: Dissertation/Thesis.
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502 $a Thesis (M.Sc.)--East Tennessee State University, 2005.
504 $a Includes bibliographical references
520 $a This research focused on investigating and comparing the cytotoxicity and cellular uptake of RRR-alpha-tocopheryl polyethylene glycol succinate (TPGS) with that of alpha-tocopheryl succinate (α-TS). Both TPGS and α-TS are water-soluble forms of vitamin E with important clinical applications. Cytotoxicity assays with RAW 264.7 and LNCaP cells incubated overnight with TPGS or α-TS at concentrations ≥ 12.4 μM suggest that α-TS is more cytotoxic than TPGS. Macrophages were found to be more sensitive than LNCaP cells when treated with similar concentrations of α-TS. For both cell lines, most of the TPGS or α-TS taken up remained esterified after 24 hours. Our results suggest that cell death was due to TPGS and/or α-TS and not alpha-tocopherol. A para-hydroxyanilide of α-TS (p-HATS) that could be used to distinguish between cellular TPGS and α-TS was studied. It was found that p-HATS can be detected electrochemically and that it is hydrolyzed to α-TOH.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2024
538 $a Mode of access: World Wide Web
650 4 $a Analytical chemistry. $3 1182118
650 4 $a Biochemistry. $3 582831
650 4 $a Physical chemistry. $3 1148725
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