國立虎尾科技大學 |

Pathophysiology of cerebellar-induced motor disorders.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	Pathophysiology of cerebellar-induced motor disorders./
作者:	Esra, Tara.
面頁冊數:	1 online resource (360 pages)
附註:	Source: Dissertations Abstracts International, Volume: 74-07, Section: B.
Contained By:	Dissertations Abstracts International74-07B.
標題:	Neurosciences. -
電子資源:	click for full text (PQDT)
ISBN:	9781267748836

Pathophysiology of cerebellar-induced motor disorders.
Esra, Tara.

Pathophysiology of cerebellar-induced motor disorders. - 1 online resource (360 pages)

Source: Dissertations Abstracts International, Volume: 74-07, Section: B.

Thesis (Ph.D.)--Yeshiva University, 2012.

Includes bibliographical references

Inherited ataxias comprise a genetically highly heterogeneous group of disorders, with their underlying dysfunction typically cerebellar in origin. Even so, in all of them a similar set of motor symptoms ultimately characterizes the phenotype in affected individuals. The physiological basis of most hereditary forms of ataxia is poorly understood and the therapeutic options either limited or nonexistent. The wide range of genes and mutations implicated in motor deficits implicating the cerebellum indicate that multiple pathways can induce cerebellar dysfunction. The overarching goal of this thesis is to characterize cerebellar pathophysiology by examining cerebellar output patterns associated with the expression of symptoms as part of inherited syndromes. Chapter 2 investigates a physiological basis for the cerebellum's debated involvement in the expression of abnormal involuntary movements in a mouse model of episodic ataxia type 2. In chapter 3, a potential mechanism underlying the paroxysmal nature of these motor symptoms in episodic ataxia is proposed. Chapter 4 evaluates whether spinocerebellar ataxias always result from neuronal degeneration by examining the physiological underpinnings of spinocerebellar ataxia 8. Chapter 5 investigated whether cerebellar activity is altered in a mutant mouse whose genetic mutations in humans results in cerebellar malformation. Although the mutated genes in episodic ataxia, spinocerebellar ataxia and cerebellar hypoplasia are different and the symptoms involve dyskinesia and dystonia in the former and mild ataxia in the latter, similar aberrant cerebellar output patterns were found to associate with all three syndromes. The final chapter investigated the hypothesis that similar changes in the firing pattern of cerebellar output neurons can give rise to a spectrum of motor dysfunction delimited on one end by ataxia and on the other by dystonia.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9781267748836Subjects--Topical Terms:

593561
Neurosciences.
Subjects--Index Terms:

AyaxiaIndex Terms--Genre/Form:

554714
Electronic books.

Pathophysiology of cerebellar-induced motor disorders.
LDR:03380ntm a22004457 4500 001 1148272
005 20240916070044.5
006 m o d
007 cr bn ---uuuuu
008 250605s2012 xx obm 000 0 eng d
020 $a 9781267748836
035 $a (MiAaPQ)AAI3532195
035 $a AAI3532195
040 $a MiAaPQ $b eng $c MiAaPQ $d NTU
100 1 $a Esra, Tara. $3 1474206
245 1 0 $a Pathophysiology of cerebellar-induced motor disorders.
264 0 $c 2012
300 $a 1 online resource (360 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 74-07, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Khodakhah, Kamran.
502 $a Thesis (Ph.D.)--Yeshiva University, 2012.
504 $a Includes bibliographical references
520 $a Inherited ataxias comprise a genetically highly heterogeneous group of disorders, with their underlying dysfunction typically cerebellar in origin. Even so, in all of them a similar set of motor symptoms ultimately characterizes the phenotype in affected individuals. The physiological basis of most hereditary forms of ataxia is poorly understood and the therapeutic options either limited or nonexistent. The wide range of genes and mutations implicated in motor deficits implicating the cerebellum indicate that multiple pathways can induce cerebellar dysfunction. The overarching goal of this thesis is to characterize cerebellar pathophysiology by examining cerebellar output patterns associated with the expression of symptoms as part of inherited syndromes. Chapter 2 investigates a physiological basis for the cerebellum's debated involvement in the expression of abnormal involuntary movements in a mouse model of episodic ataxia type 2. In chapter 3, a potential mechanism underlying the paroxysmal nature of these motor symptoms in episodic ataxia is proposed. Chapter 4 evaluates whether spinocerebellar ataxias always result from neuronal degeneration by examining the physiological underpinnings of spinocerebellar ataxia 8. Chapter 5 investigated whether cerebellar activity is altered in a mutant mouse whose genetic mutations in humans results in cerebellar malformation. Although the mutated genes in episodic ataxia, spinocerebellar ataxia and cerebellar hypoplasia are different and the symptoms involve dyskinesia and dystonia in the former and mild ataxia in the latter, similar aberrant cerebellar output patterns were found to associate with all three syndromes. The final chapter investigated the hypothesis that similar changes in the firing pattern of cerebellar output neurons can give rise to a spectrum of motor dysfunction delimited on one end by ataxia and on the other by dystonia.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2024
538 $a Mode of access: World Wide Web
650 4 $a Neurosciences. $3 593561
650 4 $a Cellular biology. $3 1148666
650 4 $a Pathology. $3 668553
650 4 $a Physiology. $3 673386
653 $a Ayaxia
653 $a Cerebellum
653 $a Dystonia
653 $a Episodic ataxia
653 $a Motor disorders
653 $a Purkinje cels
653 $a Spinocerebellar ataxia
655 7 $a Electronic books. $2 local $3 554714
690 $a 0317
690 $a 0379
690 $a 0571
690 $a 0719
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a Yeshiva University. $3 1194992
773 0 $t Dissertations Abstracts International $g 74-07B.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3532195 $z click for full text (PQDT)