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Spasm Intensity and Modulation by Serotonin Across Spinal Cord Injury Severities.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Spasm Intensity and Modulation by Serotonin Across Spinal Cord Injury Severities./
Author:	Shelton, Owen Adio.
Description:	1 online resource (60 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 84-11, Section: B.
Contained By:	Dissertations Abstracts International84-11B.
Subject:	Neurosciences. -
Online resource:	click for full text (PQDT)
ISBN:	9798379588472

Spasm Intensity and Modulation by Serotonin Across Spinal Cord Injury Severities.
Shelton, Owen Adio.

Spasm Intensity and Modulation by Serotonin Across Spinal Cord Injury Severities. - 1 online resource (60 pages)

Source: Dissertations Abstracts International, Volume: 84-11, Section: B.

Thesis (Ph.D.)--Northwestern University, 2023.

Includes bibliographical references

Involuntary motor activities such as spasms arise from hyperreflexia in about 70% of individuals with spinal cord injuries (SCI). Despite this prevalence and the negative impact on health and safety, it is unclear what determines the severity of the spasms that develop. This study investigated the impact of injury severity and functional outcome on hyperreflexia intensity in a mouse model of SCI. Hyperreflexia of awake, behaving mice was examined by recording motor outputs ex vivo and in vivo in response to electrical sensory stimuli. A lack of difference in hyperreflexia between the injury groups and the functional groups suggests that hyperreflexia arising from a complete transection can be just as severe as from a milder SCI. When serotonin (5HT) was added to the ex vivo preparation, 5HT increased the intensity of spasms regardless of injury group.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798379588472Subjects--Topical Terms:

593561
Neurosciences.
Subjects--Index Terms:

Movement disorderIndex Terms--Genre/Form:

554714
Electronic books.

Spasm Intensity and Modulation by Serotonin Across Spinal Cord Injury Severities.
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520 $a Involuntary motor activities such as spasms arise from hyperreflexia in about 70% of individuals with spinal cord injuries (SCI). Despite this prevalence and the negative impact on health and safety, it is unclear what determines the severity of the spasms that develop. This study investigated the impact of injury severity and functional outcome on hyperreflexia intensity in a mouse model of SCI. Hyperreflexia of awake, behaving mice was examined by recording motor outputs ex vivo and in vivo in response to electrical sensory stimuli. A lack of difference in hyperreflexia between the injury groups and the functional groups suggests that hyperreflexia arising from a complete transection can be just as severe as from a milder SCI. When serotonin (5HT) was added to the ex vivo preparation, 5HT increased the intensity of spasms regardless of injury group.
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