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Hypothalamic Astrocytes Expressing Melanocortin-4 Receptors Regulate Inflammation and Body Weight Homeostasis.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Hypothalamic Astrocytes Expressing Melanocortin-4 Receptors Regulate Inflammation and Body Weight Homeostasis./
Author:	Eliason, Nicole Lee.
Description:	1 online resource (155 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 84-12, Section: B.
Contained By:	Dissertations Abstracts International84-12B.
Subject:	Neurosciences. -
Online resource:	click for full text (PQDT)
ISBN:	9798379746506

Hypothalamic Astrocytes Expressing Melanocortin-4 Receptors Regulate Inflammation and Body Weight Homeostasis.
Eliason, Nicole Lee.

Hypothalamic Astrocytes Expressing Melanocortin-4 Receptors Regulate Inflammation and Body Weight Homeostasis. - 1 online resource (155 pages)

Source: Dissertations Abstracts International, Volume: 84-12, Section: B.

Thesis (Ph.D.)--The University of Oklahoma Health Sciences Center, 2023.

Includes bibliographical references

The obesity epidemic continues to plague communities on a global scale, decreasing quality of life through physical impediments and co-morbid disease states. Within the obese population, there is a spectrum of metabolic health parameters that can operate independent of adiposity severity. This phenomenon has led the scientific field to investigate pathways within obesity that modulate systemic health. The hypothalamus is the major regulator of body homeostasis within the brain and facilitates appetitive behaviors and metabolism through the melanocortin system. Specifically, melanocortin peptide activity on melanocortin-4 receptors (MC4R) mediates potent effects on anorexigenic behaviors, energy balance and inflammation. The focus of melanocortin research has been on general or neuronal MC4R, with only recent studies identifying an astrocytic population (aMC4R). Astrocytes are vital regulators of neuronal health and cerebrovascular communication which are essential for the central integration and proliferation of responses to nutritional state. Combining genetic mouse lines and targeted hypothalamic viral injections has allowed us to selectively knock-down (KD) the aMC4R population to determine its role in body weight and inflammatory homeostasis. We found that deletion of aMC4R in healthy mice results in significantly increased markers of central inflammation and body weight as fat mass. Follow-up studies conducted in a diet-induced obese model showed endogenous dysregulation of the hypothalamic aMC4R population particularly in males which were not significantly affected by the KD. aMC4R KD females, however, still gained a significant amount of fat mass regardless of obesity status. These results indicate that aMC4R plays a critical role in maintaining central and peripheral measures of health that are naturally dysregulated in an obese condition.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798379746506Subjects--Topical Terms:

593561
Neurosciences.
Subjects--Index Terms:

AstrocytesIndex Terms--Genre/Form:

554714
Electronic books.

Hypothalamic Astrocytes Expressing Melanocortin-4 Receptors Regulate Inflammation and Body Weight Homeostasis.
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