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Mechanisms of Vascular Endothelial Dysfunction in Chronic E-Cigarette Users.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Mechanisms of Vascular Endothelial Dysfunction in Chronic E-Cigarette Users./
Author:	Halstead, Kristen.
Description:	1 online resource (53 pages)
Notes:	Source: Masters Abstracts International, Volume: 85-01.
Contained By:	Masters Abstracts International85-01.
Subject:	Physiology. -
Online resource:	click for full text (PQDT)
ISBN:	9798379786090

Mechanisms of Vascular Endothelial Dysfunction in Chronic E-Cigarette Users.
Halstead, Kristen.

Mechanisms of Vascular Endothelial Dysfunction in Chronic E-Cigarette Users. - 1 online resource (53 pages)

Source: Masters Abstracts International, Volume: 85-01.

Thesis (M.S.)--The University of Iowa, 2023.

Includes bibliographical references

Tobacco and nicotine use cause vascular endothelial dysfunction, thus increasing lifetime cardiovascular disease (CVD) risk. Whether this is also true for e-cigarette use remains unknown. Tobacco cigarette smoking leads to higher CVD burden in females compared to males, but no studies of e-cigarette use have examined sex-differences in vascular responses that inform lifetime CVD risk. Chronic e-cigarette use is reported to decrease endothelial function, a potent predictor of future CVD risk. However, the mechanism(s) mediating this reduction remain unclear.Using the cutaneous circulation as a model, we examined endothelium- and nitric oxide (NO)-dependent dilation, and the role of oxidative stress in attenuating these responses, in otherwise healthy, young chronic (≥6 months) e-cigarette users (EC) compared to healthy controls (HC). 20 HC (21±2 yrs; 10M/10F) and 20 EC (21±2 yrs; 10M/8F) underwent a standard local heating protocol (42°C; 0.1°C·s-1). Two intradermal microdialysis fibers were placed in the ventral forearm skin for local delivery of lactated Ringer's (control), or 10µM tempol (superoxide dismutase mimetic). After full expression of the local heating response, 15mM NG-nitro-L-arginine methyl ester (L-NAME; NO synthase-inhibition) was perfused. Red cell flux was measured continuously by laser-Doppler flowmetry, and cutaneous vascular conductance (CVC=flux/MAP) was standardized to maximum (%CVCmax; 28mM SNP + 43°C).Between groups, endothelium- (EC: 73.1 ± 14.3 vs HC: 86.5 ± 8.9 %CVCmax; p<0.001) and NO-dependent (EC: 49.5 ± 18.1% vs HC: 61.8 ± 14.7%) dilation were attenuated in EC compared to HC. Local tempol perfusion increased endothelium- (83.6 ± 11.6 %CVCmax; p=0.01) and NO-dependent (62.6 ± 13.5%; p=0.005) dilation in EC but had no effect in HC (all p>0.05). Within sex, female EC had lower endothelium- (EC: 71.0 ± 13.3 vs HC: 89.1 ± 7.3 %CVCmax; p=0.002) and NO-dependent (EC: 46.9±5.5 vs HC: 69.4±10.8%; p=0.005) dilation compared to female HC. There were no differences between these responses in HC and EC males (both p>0.05). Tempol perfusion augmented endothelium- (83.1 ± 12.8 %CVCmax; p=0.002) and NO-dependent (62.3 ± 13.1%; p=0.015) dilation in EC females but had no effect in EC males (both p>0.05). These data suggest that otherwise healthy young adult e-cigarette users have reduced microvascular endothelium- and NO-dependent dilation. Within e-cigarette users, these results are driven by greater reductions in females. Oxidative stress, and specifically superoxide anion, contributes to these impairments. Females who use e-cigarettes demonstrate greater reductions in endothelial function and may have increased risk for developing future CVD.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798379786090Subjects--Topical Terms:

673386
Physiology.
Subjects--Index Terms:

Electronic cigarettesIndex Terms--Genre/Form:

554714
Electronic books.

Mechanisms of Vascular Endothelial Dysfunction in Chronic E-Cigarette Users.
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