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Investigating Smooth Muscle Myosin Dynamics and Assembly in Physiology and Pathology.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Investigating Smooth Muscle Myosin Dynamics and Assembly in Physiology and Pathology./
Author:	Bennett, Margaret.
Description:	1 online resource (103 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
Contained By:	Dissertations Abstracts International85-01B.
Subject:	Cellular biology. -
Online resource:	click for full text (PQDT)
ISBN:	9798379944001

Investigating Smooth Muscle Myosin Dynamics and Assembly in Physiology and Pathology.
Bennett, Margaret.

Investigating Smooth Muscle Myosin Dynamics and Assembly in Physiology and Pathology. - 1 online resource (103 pages)

Source: Dissertations Abstracts International, Volume: 85-01, Section: B.

Thesis (Ph.D.)--Loyola University Chicago, 2023.

Includes bibliographical references

Vascular smooth muscle cells (SMCs) line blood vessels throughout the body, where they dynamically alter vessel diameter to regulate blood pressure, provide structural integrity, and absorb shock on a beat-to-beat timescale. These mechanical and contractile functions are powered by the actin and smooth muscle myosin 2 cytoskeleton. To function, smooth muscle myosin transitions between an inactive monomeric state and an active filamentous state, which can then perform work on actin. Understanding the regulation of smooth muscle myosin activation at the molecular and cellular level is foundational for understanding tissue-level smooth muscle function and dysfunction in disease states. Indeed, mutations in smooth muscle myosin and dysregulation of actomyosin contractility are known drivers of smooth muscle pathologies, such as aortic aneurysms. The overarching goal of this work is to explore filament assembly and dynamics of smooth muscle myosin under normal physiological conditions, and look into how these may be changed in novel and pathology associated mutations.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798379944001Subjects--Topical Terms:

1148666
Cellular biology.
Subjects--Index Terms:

Vascular smooth muscle cellsIndex Terms--Genre/Form:

554714
Electronic books.

Investigating Smooth Muscle Myosin Dynamics and Assembly in Physiology and Pathology.
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245 1 0 $a Investigating Smooth Muscle Myosin Dynamics and Assembly in Physiology and Pathology.
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500 $a Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
500 $a Advisor: Beach, Jordan.
502 $a Thesis (Ph.D.)--Loyola University Chicago, 2023.
504 $a Includes bibliographical references
520 $a Vascular smooth muscle cells (SMCs) line blood vessels throughout the body, where they dynamically alter vessel diameter to regulate blood pressure, provide structural integrity, and absorb shock on a beat-to-beat timescale. These mechanical and contractile functions are powered by the actin and smooth muscle myosin 2 cytoskeleton. To function, smooth muscle myosin transitions between an inactive monomeric state and an active filamentous state, which can then perform work on actin. Understanding the regulation of smooth muscle myosin activation at the molecular and cellular level is foundational for understanding tissue-level smooth muscle function and dysfunction in disease states. Indeed, mutations in smooth muscle myosin and dysregulation of actomyosin contractility are known drivers of smooth muscle pathologies, such as aortic aneurysms. The overarching goal of this work is to explore filament assembly and dynamics of smooth muscle myosin under normal physiological conditions, and look into how these may be changed in novel and pathology associated mutations.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2024
538 $a Mode of access: World Wide Web
650 4 $a Cellular biology. $3 1148666
650 4 $a Physiology. $3 673386
650 4 $a Pathology. $3 668553
653 $a Vascular smooth muscle cells
653 $a Aortic aneurysms
653 $a Pathology associated mutations
653 $a Actomyosin
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