國立虎尾科技大學 |

Sensorimotor Integration in Parkinson's Disease During Lower Limb Movements.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	Sensorimotor Integration in Parkinson's Disease During Lower Limb Movements./
作者:	Tran, Stephanie.
面頁冊數:	1 online resource (160 pages)
附註:	Source: Dissertations Abstracts International, Volume: 85-05, Section: B.
Contained By:	Dissertations Abstracts International85-05B.
標題:	Neurosciences. -
電子資源:	click for full text (PQDT)
ISBN:	9798380835558

Sensorimotor Integration in Parkinson's Disease During Lower Limb Movements.
Tran, Stephanie.

Sensorimotor Integration in Parkinson's Disease During Lower Limb Movements. - 1 online resource (160 pages)

Source: Dissertations Abstracts International, Volume: 85-05, Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2023.

Includes bibliographical references

External sensory information can be applied to facilitate balance in Parkinson's disease (PD); however, in some instances, it can also disrupt movement (e.g., doorways and fast auditory cues). We examined visual-vestibular sensory integration during gait (Study 1) and neural oscillatory activity in response to doorways (Study 2) and auditory cues (Study 3) during foot pedaling. In Study 1, we tested 13 people with PD, 13 older adults (OA), and 15 young adults (YA). While walking in a virtual environment, visual and vestibular perturbations were applied to cause deviations in gait trajectories. We found that people with PD and OA integrated perturbed sensory information and showed more gait deviations than YA. In Study 2, we tested 19 people with PD while seated with electroencephalography. They were required to bilaterally pedal their feet to navigate through a virtual series of doors. Doorway-provoked lower limb motor blocks (LLMB) correlated with freezing severity and were associated with decreased beta and theta oscillations in the left temporal pole. Dopaminergic medications increased beta and theta power in the left fusiform gyrus and reduced LLMB percent durations. In Study 3, we tested 25 people with PD undergoing deep brain stimulation surgery. We recorded in the globus pallidus internus (GPi) or subthalamic nucleus (STN) while they pedaled their feet in a supine position in synchrony with auditory cues. We found that the GPi responded to the sensory aspect of the task, showing tonic beta desynchronization with fast cue frequencies. The STN responded to motor aspects of the task with beta rebounds following motor onset. Overall, we show that i) visual-vestibular sensory integration may be preserved in PD, and ii) motor block triggers, such as doorways and fast auditory cues, are related to decreased oscillatory activity in the ventral visual pathway and increased beta modulations in the basal ganglia. Understanding the role of these neurophysiological changes can open avenues to improve treatment in PD.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798380835558Subjects--Topical Terms:

593561
Neurosciences.
Subjects--Index Terms:

BalanceIndex Terms--Genre/Form:

554714
Electronic books.

Sensorimotor Integration in Parkinson's Disease During Lower Limb Movements.
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