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Progressive Changes in Global Gene Expression Underpinning Muscle Senescence in Manduca sexta.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Progressive Changes in Global Gene Expression Underpinning Muscle Senescence in Manduca sexta./
Author:	Del Grosso, Avery.
Description:	1 online resource (111 pages)
Notes:	Source: Masters Abstracts International, Volume: 82-12.
Contained By:	Masters Abstracts International82-12.
Subject:	Molecular biology. -
Online resource:	click for full text (PQDT)
ISBN:	9798738649288

Progressive Changes in Global Gene Expression Underpinning Muscle Senescence in Manduca sexta.
Del Grosso, Avery.

Progressive Changes in Global Gene Expression Underpinning Muscle Senescence in Manduca sexta. - 1 online resource (111 pages)

Source: Masters Abstracts International, Volume: 82-12.

Thesis (M.S.)--University of South Dakota, 2021.

Includes bibliographical references

Muscle aging is a complex dynamic process that adversely affects whole-animal metabolism and physiology. The molecular regulation of aging muscle that impacts muscle function, performance, and metabolism remains largely unknown because such studies in model organisms are prohibitively time- and resource-intensive. The hawk moth, Manduca sexta, offers a unique opportunity to identify the genes that coordinate the muscle aging process. With a complete lifespan of about ten days and their high similarity to vertebrate muscle systems, this non-vertebrate animal model is ideal to conduct a molecular dissection of the regulatory genes underpinning the senescence process in muscles. Here, we report decreased gene expression of genes related to fatty acid β-oxidation, ATP synthase subunits, superoxide dismutase, glutathione S-transferases, and heat shock proteins, and increased gene expression of genes related to proteolysis, catabolic processes, insulin receptors, akirin, titin, high-affinity choline transporters, and vesicular acetylcholine transporters from a high-resolution time course sampling of muscle tissue from middle age to advanced age male moths. These results suggest an age-related shift towards proteolysis and catabolism of proteins and suggest M. sexta is an ideal complementary aging model. However, it remains unclear if the data are the result of starvation in male M. sexta or aging.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798738649288Subjects--Topical Terms:

583443
Molecular biology.
Subjects--Index Terms:

AgingIndex Terms--Genre/Form:

554714
Electronic books.

Progressive Changes in Global Gene Expression Underpinning Muscle Senescence in Manduca sexta.
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520 $a Muscle aging is a complex dynamic process that adversely affects whole-animal metabolism and physiology. The molecular regulation of aging muscle that impacts muscle function, performance, and metabolism remains largely unknown because such studies in model organisms are prohibitively time- and resource-intensive. The hawk moth, Manduca sexta, offers a unique opportunity to identify the genes that coordinate the muscle aging process. With a complete lifespan of about ten days and their high similarity to vertebrate muscle systems, this non-vertebrate animal model is ideal to conduct a molecular dissection of the regulatory genes underpinning the senescence process in muscles. Here, we report decreased gene expression of genes related to fatty acid β-oxidation, ATP synthase subunits, superoxide dismutase, glutathione S-transferases, and heat shock proteins, and increased gene expression of genes related to proteolysis, catabolic processes, insulin receptors, akirin, titin, high-affinity choline transporters, and vesicular acetylcholine transporters from a high-resolution time course sampling of muscle tissue from middle age to advanced age male moths. These results suggest an age-related shift towards proteolysis and catabolism of proteins and suggest M. sexta is an ideal complementary aging model. However, it remains unclear if the data are the result of starvation in male M. sexta or aging.
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653 $a Time-series RNA-Seq
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