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The Design and Characterization of a Piezoelectric PVDF-TrFE Nanofiber Scaffold for Nerve Repair Applications.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	The Design and Characterization of a Piezoelectric PVDF-TrFE Nanofiber Scaffold for Nerve Repair Applications./
Author:	Wolf, Ann.
Description:	1 online resource (62 pages)
Notes:	Source: Masters Abstracts International, Volume: 84-01.
Contained By:	Masters Abstracts International84-01.
Subject:	Electrical engineering. -
Online resource:	click for full text (PQDT)
ISBN:	9798802742402

The Design and Characterization of a Piezoelectric PVDF-TrFE Nanofiber Scaffold for Nerve Repair Applications.
Wolf, Ann.

The Design and Characterization of a Piezoelectric PVDF-TrFE Nanofiber Scaffold for Nerve Repair Applications. - 1 online resource (62 pages)

Source: Masters Abstracts International, Volume: 84-01.

Thesis (M.S.)--University of Cincinnati, 2022.

Includes bibliographical references

Severe peripheral nerve injuries are currently limited in their available treatment approaches. Standard clinical therapies include the use of nerve grafts or nerve conduits to guide axons across the injury gap, however many of these approaches show variable outcomes in functional recovery, possibly due to a lack of cues directing the nerve regeneration. Polyvinylidene flouride triflouroethylene (PVDF-TrFE) is a piezoelectric polymer that generates electric charge in response to mechanical deformation, and can provide a suitable regenerative microenvironment by imparting electrical stimulation to direct peripheral nervous system cells and function. In this thesis, PVDF-TrFE nanofibrous scaffolds are fabricated through electrospinning and are extensively characterized for their material and electrical properties. Further, the PVDF-TrFE scaffolds are functionalized with decellularized extracellular matrix (dECM), presenting a promising outlook for a piezoelectric biomaterial for tissue engineering.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798802742402Subjects--Topical Terms:

596380
Electrical engineering.
Subjects--Index Terms:

Piezoelectric polymerIndex Terms--Genre/Form:

554714
Electronic books.

The Design and Characterization of a Piezoelectric PVDF-TrFE Nanofiber Scaffold for Nerve Repair Applications.
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520 $a Severe peripheral nerve injuries are currently limited in their available treatment approaches. Standard clinical therapies include the use of nerve grafts or nerve conduits to guide axons across the injury gap, however many of these approaches show variable outcomes in functional recovery, possibly due to a lack of cues directing the nerve regeneration. Polyvinylidene flouride triflouroethylene (PVDF-TrFE) is a piezoelectric polymer that generates electric charge in response to mechanical deformation, and can provide a suitable regenerative microenvironment by imparting electrical stimulation to direct peripheral nervous system cells and function. In this thesis, PVDF-TrFE nanofibrous scaffolds are fabricated through electrospinning and are extensively characterized for their material and electrical properties. Further, the PVDF-TrFE scaffolds are functionalized with decellularized extracellular matrix (dECM), presenting a promising outlook for a piezoelectric biomaterial for tissue engineering.
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653 $a Piezoelectric polymer
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