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Quantitative Evaluation of Simultaneous Selective Ion Clustering and Hydrogen/Deuterium Exchange.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Quantitative Evaluation of Simultaneous Selective Ion Clustering and Hydrogen/Deuterium Exchange./
Author:	Schramm, Haley M.
Description:	1 online resource (191 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
Contained By:	Dissertations Abstracts International85-12B.
Subject:	Chemistry. -
Online resource:	click for full text (PQDT)
ISBN:	9798383123409

Quantitative Evaluation of Simultaneous Selective Ion Clustering and Hydrogen/Deuterium Exchange.
Schramm, Haley M.

Quantitative Evaluation of Simultaneous Selective Ion Clustering and Hydrogen/Deuterium Exchange. - 1 online resource (191 pages)

Source: Dissertations Abstracts International, Volume: 85-12, Section: B.

Thesis (Ph.D.)--Washington State University, 2024.

Includes bibliographical references

Recent efforts in ion mobility coupled to mass spectrometry have enhanced the confidence in describing gas-phase ion structures. Hydrogen/deuterium exchange is highly studied in condensed phases as a chemical tool for indirect structural analysis, but wider adoption of gas-phase methods is hindered by low deuterium incorporation and restrictions of in vacuo experiments. To combine the chemical tools of ion clustering and isotope exchange with the physical separation tool of ion mobility, an atmospheric pressure drift cell was used as a reaction vessel. The increased collision rate of ions and neutrals at ambient conditions enabled increased exchange for amino acids and peptides and comparable exchange levels in proteins in millisecond reactions times. The multimodal data obtained from this method shows a direct link between localized ion solvation and exchange kinetics. Multiple distinctly reactive ion populations are detected in all the analytes studied with unprecedented speed and selectivity. These experiments elucidated new insights into the structure and solvation of single amino acids, peptide, and protein ions currently unattainable with commercial instrumentation.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798383123409Subjects--Topical Terms:

593913
Chemistry.
Subjects--Index Terms:

Mass spectrometryIndex Terms--Genre/Form:

554714
Electronic books.

Quantitative Evaluation of Simultaneous Selective Ion Clustering and Hydrogen/Deuterium Exchange.
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500 $a Advisor: Clowers, Brian H.
502 $a Thesis (Ph.D.)--Washington State University, 2024.
504 $a Includes bibliographical references
520 $a Recent efforts in ion mobility coupled to mass spectrometry have enhanced the confidence in describing gas-phase ion structures. Hydrogen/deuterium exchange is highly studied in condensed phases as a chemical tool for indirect structural analysis, but wider adoption of gas-phase methods is hindered by low deuterium incorporation and restrictions of in vacuo experiments. To combine the chemical tools of ion clustering and isotope exchange with the physical separation tool of ion mobility, an atmospheric pressure drift cell was used as a reaction vessel. The increased collision rate of ions and neutrals at ambient conditions enabled increased exchange for amino acids and peptides and comparable exchange levels in proteins in millisecond reactions times. The multimodal data obtained from this method shows a direct link between localized ion solvation and exchange kinetics. Multiple distinctly reactive ion populations are detected in all the analytes studied with unprecedented speed and selectivity. These experiments elucidated new insights into the structure and solvation of single amino acids, peptide, and protein ions currently unattainable with commercial instrumentation.
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538 $a Mode of access: World Wide Web
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650 4 $a Physical chemistry. $3 1148725
650 4 $a Inorganic chemistry. $3 1182077
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653 $a Ion mobility
653 $a Exchange kinetics
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