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A New Spin on the Origin of Biological Homochirality.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	A New Spin on the Origin of Biological Homochirality./
Author:	Ozturk, Sukru Furkan.
Description:	1 online resource (233 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
Contained By:	Dissertations Abstracts International85-12B.
Subject:	Physics. -
Online resource:	click for full text (PQDT)
ISBN:	9798382775647

A New Spin on the Origin of Biological Homochirality.
Ozturk, Sukru Furkan.

A New Spin on the Origin of Biological Homochirality. - 1 online resource (233 pages)

Source: Dissertations Abstracts International, Volume: 85-12, Section: B.

Thesis (Ph.D.)--Harvard University, 2024.

Includes bibliographical references

Essential molecules of life-amino acids, nucleic acids, and sugars-are chiral; they exist in mirror-symmetrical pairs. However, biological systems exclusively use only one form of these pairs: right-handed sugars and nucleic acids, along with left-handed amino acids. This phenomenon characterizes life as homochiral. However, the origins of this asymmetry remain elusive, and it is this long-standing mystery that we address in this thesis.The chiral-induced spin selectivity (CISS) effect has established a strong coupling between electron spin and molecular chirality and this coupling paves the way for breaking the chiral molecular symmetry by spin-selective processes. Achiral magnetic surfaces, when spin-polarized, can function as chiral agents due to the CISS effect, serving as templates for the asymmetric crystallization of chiral molecules.In this thesis, we studied the spin-selective crystallization of racemic ribo-aminooxazoline (RAO), a central precursor of RNA, on magnetite surfaces-achieving homochirality in two crystallization steps. Moreover, we have shown the chirality-induced avalanche magnetization of magnetite by RAO molecules, which verifies the reciprocal nature of the effect and allows for a cooperative feedback between chiral molecules and magnetic surfaces. Finally, based on empirical evidence, we propose a pathway through which the achieved homochirality in a single chiral compound, RAO, can efficiently propagate throughout the entire prebiotic network, starting from D-nucleic acids, to L-peptides, and then to homochiral metabolites.Our results demonstrate a prebiotically plausible way of achieving systems-level homochirality from completely racemic starting materials through a process initiated by the physical environment.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798382775647Subjects--Topical Terms:

564049
Physics.
Subjects--Index Terms:

Chiral-induced spin selectivityIndex Terms--Genre/Form:

554714
Electronic books.

A New Spin on the Origin of Biological Homochirality.
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504 $a Includes bibliographical references
520 $a Essential molecules of life-amino acids, nucleic acids, and sugars-are chiral; they exist in mirror-symmetrical pairs. However, biological systems exclusively use only one form of these pairs: right-handed sugars and nucleic acids, along with left-handed amino acids. This phenomenon characterizes life as homochiral. However, the origins of this asymmetry remain elusive, and it is this long-standing mystery that we address in this thesis.The chiral-induced spin selectivity (CISS) effect has established a strong coupling between electron spin and molecular chirality and this coupling paves the way for breaking the chiral molecular symmetry by spin-selective processes. Achiral magnetic surfaces, when spin-polarized, can function as chiral agents due to the CISS effect, serving as templates for the asymmetric crystallization of chiral molecules.In this thesis, we studied the spin-selective crystallization of racemic ribo-aminooxazoline (RAO), a central precursor of RNA, on magnetite surfaces-achieving homochirality in two crystallization steps. Moreover, we have shown the chirality-induced avalanche magnetization of magnetite by RAO molecules, which verifies the reciprocal nature of the effect and allows for a cooperative feedback between chiral molecules and magnetic surfaces. Finally, based on empirical evidence, we propose a pathway through which the achieved homochirality in a single chiral compound, RAO, can efficiently propagate throughout the entire prebiotic network, starting from D-nucleic acids, to L-peptides, and then to homochiral metabolites.Our results demonstrate a prebiotically plausible way of achieving systems-level homochirality from completely racemic starting materials through a process initiated by the physical environment.
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