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Intravascular Sonothrombolysis with Magnetic Microbubbles and Nanodroplets.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Intravascular Sonothrombolysis with Magnetic Microbubbles and Nanodroplets./
Author:	Zhang, Bohua.
Description:	1 online resource (261 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
Contained By:	Dissertations Abstracts International85-01B.
Subject:	Study abroad. -
Online resource:	click for full text (PQDT)
ISBN:	9798379871246

Intravascular Sonothrombolysis with Magnetic Microbubbles and Nanodroplets.
Zhang, Bohua.

Intravascular Sonothrombolysis with Magnetic Microbubbles and Nanodroplets. - 1 online resource (261 pages)

Source: Dissertations Abstracts International, Volume: 85-01, Section: B.

Thesis (Ph.D.)--North Carolina State University, 2023.

Includes bibliographical references

Thrombosis disease continues to be one of the leading causes of death and disability on a global scale. Ultrasound has been widely used to treat thrombosis-related diseases such as stroke, deep vein thrombosis, and pulmonary embolism. However, the safety and efficacy are still limited for clinical application. The central theme of this dissertation is the development of novel intravascular ultrasound transducers for fast and effective sonothrombolysis with cavitation agents such as magnetic microbubbles, microbubbles, and nanodroplets. Five different types of intravascular ultrasound transducers were designed and prototyped for therapeutic applications: 1) Magnetic and ultrasound dual-mode stacked transducer for sonothrombolysis with microbubbles and nanodroplets combined with magnetic nanoparticles. 2) Forward-viewing, laser-coupled composite dual-mode intravascular ultrasound transducer for microbubbles-mediated sonothrombolysis. 4) Forward-viewing, low-frequency, intravascular ultrasound stacked transducer for magnetic microbubbles and nanodroplets-mediated sonothrombolysis in a rotational magnetic field. 5) Laser sensor-guided intravascular stacked transducer with real-time clot detection and magnetic scanning function for enhanced microbubble-mediated sonothrombolysis. 6) Forward-viewing, vortex intravascular stacked ultrasound transducer for acute clot microbubbles-mediated sonothrombolysis.Two types of magnetic and ultrasound dual-mode stacked transducer were developed for dual-excitation thrombolysis. For the single-element, 40-layer dual-mode stacked transducer, the center frequency is around 102 kHz, and the maximum peak-negative-pressure (PNP) was over 5.0 MPa. The center frequency for the four-element array dual-mode stacked transducer is around 446 kHz, and the maximum PNP was over 3.0 MPa. The dual-mode transducer could create ultrasound waves and a high-frequency oscillating magnetic field to activate the magnetic nanoparticles, microbubbles, and nanodroplets for sonothrombolysis.The composite laser-coupled dual-mode ultrasound transducer with four piezoelectric stacks and a laser ultrasound transducer could produce both low-frequency (600 kHz) and highfrequency (7.4 MHz) stimulation. Besides, a miniaturized laser-coupled dual-mode intravascular ultrasound transducer featuring piezoelectric stacks and a laser ultrasound transducer was developed, providing a combined low-frequency (425 kHz) and high-frequency (7.2 MHz) excitation for intravascular sonothrombolysis treatment.A forward-looking, low-frequency 8-layer stacked ultrasound transducer was prototyped for intravascular sonothrombolysis. Under a driving voltage of 130 Vpp, the prototype of the ultrasound transducer had a resonance frequency of 850 kHz, an electrical impedance of 90 Ohm, and a maximum PNP of 2.48 MPa. The developed transducer could be installed on a 9 Fr catheter for magnetic microbubbles-mediated sonothrombolysis treatment.Two types of laser sensor-guided intravascular stacked transducer were developed for clot detection and sonothrombolysis. The center frequency for the ring-type stacked transducer was around 330 kHz, and the PNP was about 1.87 MPa under 120 Vpp input voltage. The laser sensor could detect the location of blood clots during the treatment. The center frequency for the magnetic scanning stacked transducer was around 536 kHz, and PNP was about 4.25 MPa under 120 Vppinput voltage. The magnetic scanning motion could significantly expand the area of transducer focus zone by 103% and improve the clot channel size by 77.8%.The vortex ultrasound transducer for endovascular sonothrombolysis was developed. The center frequency of the vortex transducer was about 2.2 MHz, and the PNP was over 4.2 MPa under 100 Vpp input voltage. The diameter of the vortex ultrasonic beam (insonation zone) is about 2.3 mm when measured at -6 dB. The vortex ultrasound could significantly improve the efficacy of large, completely occluded clot lysis due to the wave-matter interaction-induced shear stress. A record-high lytic rate of 237.5 mg/min was measured in our in-vitrotest that recanalized a 3.1 g, 7.5 cm long clot within 8 min.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798379871246Subjects--Topical Terms:

1339629
Study abroad.
Index Terms--Genre/Form:

554714
Electronic books.

Intravascular Sonothrombolysis with Magnetic Microbubbles and Nanodroplets.
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520 $a Thrombosis disease continues to be one of the leading causes of death and disability on a global scale. Ultrasound has been widely used to treat thrombosis-related diseases such as stroke, deep vein thrombosis, and pulmonary embolism. However, the safety and efficacy are still limited for clinical application. The central theme of this dissertation is the development of novel intravascular ultrasound transducers for fast and effective sonothrombolysis with cavitation agents such as magnetic microbubbles, microbubbles, and nanodroplets. Five different types of intravascular ultrasound transducers were designed and prototyped for therapeutic applications: 1) Magnetic and ultrasound dual-mode stacked transducer for sonothrombolysis with microbubbles and nanodroplets combined with magnetic nanoparticles. 2) Forward-viewing, laser-coupled composite dual-mode intravascular ultrasound transducer for microbubbles-mediated sonothrombolysis. 4) Forward-viewing, low-frequency, intravascular ultrasound stacked transducer for magnetic microbubbles and nanodroplets-mediated sonothrombolysis in a rotational magnetic field. 5) Laser sensor-guided intravascular stacked transducer with real-time clot detection and magnetic scanning function for enhanced microbubble-mediated sonothrombolysis. 6) Forward-viewing, vortex intravascular stacked ultrasound transducer for acute clot microbubbles-mediated sonothrombolysis.Two types of magnetic and ultrasound dual-mode stacked transducer were developed for dual-excitation thrombolysis. For the single-element, 40-layer dual-mode stacked transducer, the center frequency is around 102 kHz, and the maximum peak-negative-pressure (PNP) was over 5.0 MPa. The center frequency for the four-element array dual-mode stacked transducer is around 446 kHz, and the maximum PNP was over 3.0 MPa. The dual-mode transducer could create ultrasound waves and a high-frequency oscillating magnetic field to activate the magnetic nanoparticles, microbubbles, and nanodroplets for sonothrombolysis.The composite laser-coupled dual-mode ultrasound transducer with four piezoelectric stacks and a laser ultrasound transducer could produce both low-frequency (600 kHz) and highfrequency (7.4 MHz) stimulation. Besides, a miniaturized laser-coupled dual-mode intravascular ultrasound transducer featuring piezoelectric stacks and a laser ultrasound transducer was developed, providing a combined low-frequency (425 kHz) and high-frequency (7.2 MHz) excitation for intravascular sonothrombolysis treatment.A forward-looking, low-frequency 8-layer stacked ultrasound transducer was prototyped for intravascular sonothrombolysis. Under a driving voltage of 130 Vpp, the prototype of the ultrasound transducer had a resonance frequency of 850 kHz, an electrical impedance of 90 Ohm, and a maximum PNP of 2.48 MPa. The developed transducer could be installed on a 9 Fr catheter for magnetic microbubbles-mediated sonothrombolysis treatment.Two types of laser sensor-guided intravascular stacked transducer were developed for clot detection and sonothrombolysis. The center frequency for the ring-type stacked transducer was around 330 kHz, and the PNP was about 1.87 MPa under 120 Vpp input voltage. The laser sensor could detect the location of blood clots during the treatment. The center frequency for the magnetic scanning stacked transducer was around 536 kHz, and PNP was about 4.25 MPa under 120 Vppinput voltage. The magnetic scanning motion could significantly expand the area of transducer focus zone by 103% and improve the clot channel size by 77.8%.The vortex ultrasound transducer for endovascular sonothrombolysis was developed. The center frequency of the vortex transducer was about 2.2 MHz, and the PNP was over 4.2 MPa under 100 Vpp input voltage. The diameter of the vortex ultrasonic beam (insonation zone) is about 2.3 mm when measured at -6 dB. The vortex ultrasound could significantly improve the efficacy of large, completely occluded clot lysis due to the wave-matter interaction-induced shear stress. A record-high lytic rate of 237.5 mg/min was measured in our in-vitrotest that recanalized a 3.1 g, 7.5 cm long clot within 8 min.
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