國立虎尾科技大學 |

Comparison of Clinical Study Results Reported in medRxiv Preprints vs Peer-Reviewed Journal Articles.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	Comparison of Clinical Study Results Reported in medRxiv Preprints vs Peer-Reviewed Journal Articles./
作者:	Janda, Guneet Singh.
面頁冊數:	1 online resource (53 pages)
附註:	Source: Dissertations Abstracts International, Volume: 85-11, Section: B.
Contained By:	Dissertations Abstracts International85-11B.
標題:	Journalism. -
電子資源:	click for full text (PQDT)
ISBN:	9798382321899

Comparison of Clinical Study Results Reported in medRxiv Preprints vs Peer-Reviewed Journal Articles.
Janda, Guneet Singh.

Comparison of Clinical Study Results Reported in medRxiv Preprints vs Peer-Reviewed Journal Articles. - 1 online resource (53 pages)

Source: Dissertations Abstracts International, Volume: 85-11, Section: B.

Thesis (M.D.)--Yale University, 2024.

Includes bibliographical references

The aim of this project was to evaluate the concordance among study characteristics, results, and interpretations described in preprints of clinical studies that are subsequently published in peer-reviewed journals (preprint-journal article pairs).In this cross-sectional analysis, preprints posted on medRxiv in September 2020 were identified. Four evaluators determined how many preprints were subsequently published in peer-reviewed journals as of September 2022, calculating the time from preprint posting to publication. For preprints with multiple versions, the most recent version prior to journal acceptance was selected. Preprints updated after journal acceptance were excluded. For preprint-journal article pairs describing clinical trials, observational studies, and meta-analyses that measured health-related outcomes, sample size, primary endpoints, corresponding results, and overarching conclusions were abstracted. Results from primary endpoints were only considered concordant if they contained the same information or had numerical equivalence (e.g., identical effect size estimates and 95% CIs/P-values from inferential analyses). Rates of concordance were compared between preprints and corresponding journal articles, overall and by focus on COVID-19 and journal impact factor (IF).Among 1399 preprints first posted on medRxiv in September 2020, a total of 1077 (77.0%) had been published as of September 15, 2022, a median of 6 months (IQR, 3-8 months) after preprint posting. Among the 547 preprint-journal article pairs describing clinical trials, observational studies, or meta-analyses, 293 (53.6%) were related to COVID-19. Of the 535 pairs reporting sample sizes in both sources, 462 (86.4%) were concordant; 43 (58.9%) of the 73 pairs with discordant sample sizes had larger samples in the journal publication. There were 534 pairs (97.6%) with concordant and 13 pairs (2.4%) with discordant primary end points. Among the 535 pairs with numerical results for the primary end points, 434 (81.1%) had concordant primary end point results; 66 of the 101 discordant pairs (65.3%) had effect size estimates that were in the same direction and were statistically consistent. Overall, 526 pairs (96.2%) had concordant study interpretations, including 82 of the 101 pairs (81.2%) with discordant primary end point results.Most clinical studies posted as preprints on medRxiv and subsequently published in peer-reviewed journals had concordant study characteristics, results, and final interpretations. With over three-quarters of preprints published in journals within 24 months, these results may suggest that many preprints report findings that are consistent with the final peer-reviewed publications.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798382321899Subjects--Topical Terms:

659797
Journalism.
Subjects--Index Terms:

COVID-19Index Terms--Genre/Form:

554714
Electronic books.

Comparison of Clinical Study Results Reported in medRxiv Preprints vs Peer-Reviewed Journal Articles.
LDR:04146ntm a22004217 4500 001 1151713
005 20241118085742.5
006 m o d
007 cr mn ---uuuuu
008 250605s2024 xx obm 000 0 eng d
020 $a 9798382321899
035 $a (MiAaPQ)AAI31142917
035 $a AAI31142917
040 $a MiAaPQ $b eng $c MiAaPQ $d NTU
100 1 $a Janda, Guneet Singh. $3 1478530
245 1 0 $a Comparison of Clinical Study Results Reported in medRxiv Preprints vs Peer-Reviewed Journal Articles.
264 0 $c 2024
300 $a 1 online resource (53 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 85-11, Section: B.
500 $a Advisor: Ross, Joseph S.;Wallach, Joshua D.
502 $a Thesis (M.D.)--Yale University, 2024.
504 $a Includes bibliographical references
520 $a The aim of this project was to evaluate the concordance among study characteristics, results, and interpretations described in preprints of clinical studies that are subsequently published in peer-reviewed journals (preprint-journal article pairs).In this cross-sectional analysis, preprints posted on medRxiv in September 2020 were identified. Four evaluators determined how many preprints were subsequently published in peer-reviewed journals as of September 2022, calculating the time from preprint posting to publication. For preprints with multiple versions, the most recent version prior to journal acceptance was selected. Preprints updated after journal acceptance were excluded. For preprint-journal article pairs describing clinical trials, observational studies, and meta-analyses that measured health-related outcomes, sample size, primary endpoints, corresponding results, and overarching conclusions were abstracted. Results from primary endpoints were only considered concordant if they contained the same information or had numerical equivalence (e.g., identical effect size estimates and 95% CIs/P-values from inferential analyses). Rates of concordance were compared between preprints and corresponding journal articles, overall and by focus on COVID-19 and journal impact factor (IF).Among 1399 preprints first posted on medRxiv in September 2020, a total of 1077 (77.0%) had been published as of September 15, 2022, a median of 6 months (IQR, 3-8 months) after preprint posting. Among the 547 preprint-journal article pairs describing clinical trials, observational studies, or meta-analyses, 293 (53.6%) were related to COVID-19. Of the 535 pairs reporting sample sizes in both sources, 462 (86.4%) were concordant; 43 (58.9%) of the 73 pairs with discordant sample sizes had larger samples in the journal publication. There were 534 pairs (97.6%) with concordant and 13 pairs (2.4%) with discordant primary end points. Among the 535 pairs with numerical results for the primary end points, 434 (81.1%) had concordant primary end point results; 66 of the 101 discordant pairs (65.3%) had effect size estimates that were in the same direction and were statistically consistent. Overall, 526 pairs (96.2%) had concordant study interpretations, including 82 of the 101 pairs (81.2%) with discordant primary end point results.Most clinical studies posted as preprints on medRxiv and subsequently published in peer-reviewed journals had concordant study characteristics, results, and final interpretations. With over three-quarters of preprints published in journals within 24 months, these results may suggest that many preprints report findings that are consistent with the final peer-reviewed publications.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2024
538 $a Mode of access: World Wide Web
650 4 $a Journalism. $3 659797
650 4 $a Information science. $3 561178
650 4 $a Public health. $3 560998
650 4 $a Medicine. $3 644133
653 $a COVID-19
653 $a Journal
653 $a Peer review
653 $a Preprints
653 $a Publishing
653 $a Articles
655 7 $a Electronic books. $2 local $3 554714
690 $a 0564
690 $a 0573
690 $a 0723
690 $a 0391
710 2 $a Yale University. $b Yale School of Medicine. $3 1464899
710 2 $a ProQuest Information and Learning Co. $3 1178819
773 0 $t Dissertations Abstracts International $g 85-11B.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31142917 $z click for full text (PQDT)