國立虎尾科技大學 |

Chlorophyll Derivatives With Anti-Obesity Activity.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Chlorophyll Derivatives With Anti-Obesity Activity./
Author:	Figueiredo, Ricardo.
Description:	1 online resource (82 pages)
Notes:	Source: Masters Abstracts International, Volume: 86-02.
Contained By:	Masters Abstracts International86-02.
Subject:	Body fat. -
Online resource:	click for full text (PQDT)
ISBN:	9798383771310

Chlorophyll Derivatives With Anti-Obesity Activity.
Figueiredo, Ricardo.

Chlorophyll Derivatives With Anti-Obesity Activity. - 1 online resource (82 pages)

Source: Masters Abstracts International, Volume: 86-02.

Thesis (Master's)--Universidade do Porto (Portugal), 2024.

Includes bibliographical references

Obesity represents a complex and multifactorial disease that affects a growing segment of the global population. It is linked to a spectrum of cardiovascular and psychological diseases, among others. Addressing this multifactorial disease extends well beyond lifestyle changes. Current therapeutic options carry certain health risks and are accompanied by inconveniences, particularly in the context of more invasive interventions. Consequently, research of new treatments has expanded to explore the potential of compounds naturally produced by organisms. Within these natural products, chlorophyll derivatives have sparked the interest of the scientific community. owing to the recent discovery of their lipid-reducing activity, specifically the compounds 132-hydroxy-pheophytin a e 132-hydroxy-pheofarnesin a.In this study, an optimisation of the extraction process of chlorophyll a and its derivatives was test from Arthrospira platensis biomass, a remarkable cyanobacterium that produces significant quantities of this pigment and other natural products of interest. The obtained extracts were evaluated for their lipid and appetite-reducing activities in zebrafish larvae performing the Nile Red fat metabolism bioassay and a liposome-based bioassay. Additionally, an in silicometabolomic analysis was conducted using the Global Natural Product Social Molecular Networking (GNPS) platform and relative quantification of selected chlorophyll a derivatives from liquid chromatography-mass spectrometry analyses. This approach allowed the establishment of a relationship between the extraction conditions and the relative abundances of the selected analysed compounds, the identification of bioactive extracts, and ultimately the putatively identification of compounds in these extracts.As a result, 28 extracts were obtained, with 9 of them demonstrating the ability to promote lipid reduction and 4 extracts reducing appetite in zebrafish larvae. Additionally, 9 compounds were putatively identified in some bioactive extracts and extraction protocols were developed for different derivatives of chlorophyll a.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798383771310Subjects--Topical Terms:

1467283
Body fat.
Index Terms--Genre/Form:

554714
Electronic books.

Chlorophyll Derivatives With Anti-Obesity Activity.
LDR:03345ntm a22003497 4500 001 1152463
005 20241203090601.5
006 m o d
007 cr mn ---uuuuu
008 250605s2024 xx obm 000 0 eng d
020 $a 9798383771310
035 $a (MiAaPQ)AAI31153886
035 $a (MiAaPQ)Portugal10216156819
035 $a AAI31153886
040 $a MiAaPQ $b eng $c MiAaPQ $d NTU
100 1 $a Figueiredo, Ricardo. $3 1479464
245 1 0 $a Chlorophyll Derivatives With Anti-Obesity Activity.
264 0 $c 2024
300 $a 1 online resource (82 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Masters Abstracts International, Volume: 86-02.
500 $a Advisor: Urbatzka, Ralph;Reis, Mariana.
502 $a Thesis (Master's)--Universidade do Porto (Portugal), 2024.
504 $a Includes bibliographical references
520 $a Obesity represents a complex and multifactorial disease that affects a growing segment of the global population. It is linked to a spectrum of cardiovascular and psychological diseases, among others. Addressing this multifactorial disease extends well beyond lifestyle changes. Current therapeutic options carry certain health risks and are accompanied by inconveniences, particularly in the context of more invasive interventions. Consequently, research of new treatments has expanded to explore the potential of compounds naturally produced by organisms. Within these natural products, chlorophyll derivatives have sparked the interest of the scientific community. owing to the recent discovery of their lipid-reducing activity, specifically the compounds 132-hydroxy-pheophytin a e 132-hydroxy-pheofarnesin a.In this study, an optimisation of the extraction process of chlorophyll a and its derivatives was test from Arthrospira platensis biomass, a remarkable cyanobacterium that produces significant quantities of this pigment and other natural products of interest. The obtained extracts were evaluated for their lipid and appetite-reducing activities in zebrafish larvae performing the Nile Red fat metabolism bioassay and a liposome-based bioassay. Additionally, an in silicometabolomic analysis was conducted using the Global Natural Product Social Molecular Networking (GNPS) platform and relative quantification of selected chlorophyll a derivatives from liquid chromatography-mass spectrometry analyses. This approach allowed the establishment of a relationship between the extraction conditions and the relative abundances of the selected analysed compounds, the identification of bioactive extracts, and ultimately the putatively identification of compounds in these extracts.As a result, 28 extracts were obtained, with 9 of them demonstrating the ability to promote lipid reduction and 4 extracts reducing appetite in zebrafish larvae. Additionally, 9 compounds were putatively identified in some bioactive extracts and extraction protocols were developed for different derivatives of chlorophyll a.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2024
538 $a Mode of access: World Wide Web
650 4 $a Body fat. $3 1467283
650 4 $a Insulin resistance. $3 769352
650 4 $a Body mass index. $3 1465885
650 4 $a Pharmaceuticals. $3 1413678
650 4 $a Metabolites. $3 677719
650 4 $a Obesity. $3 582756
650 4 $a Health sciences. $3 1179212
650 4 $a Pharmaceutical sciences. $3 1180569
650 4 $a Public health. $3 560998
655 7 $a Electronic books. $2 local $3 554714
690 $a 0566
690 $a 0572
690 $a 0573
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a Universidade do Porto (Portugal). $3 1188642
773 0 $t Masters Abstracts International $g 86-02.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31153886 $z click for full text (PQDT)