國立虎尾科技大學 |

Chlorophyll Derivatives With Anti-Obesity Activity.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	Chlorophyll Derivatives With Anti-Obesity Activity./
作者:	Figueiredo, Ricardo.
面頁冊數:	1 online resource (82 pages)
附註:	Source: Masters Abstracts International, Volume: 86-02.
Contained By:	Masters Abstracts International86-02.
標題:	Public health. -
電子資源:	click for full text (PQDT)
ISBN:	9798383771310

Chlorophyll Derivatives With Anti-Obesity Activity.
Figueiredo, Ricardo.

Chlorophyll Derivatives With Anti-Obesity Activity. - 1 online resource (82 pages)

Source: Masters Abstracts International, Volume: 86-02.

Thesis (Master's)--Universidade do Porto (Portugal), 2024.

Includes bibliographical references

Obesity represents a complex and multifactorial disease that affects a growing segment of the global population. It is linked to a spectrum of cardiovascular and psychological diseases, among others. Addressing this multifactorial disease extends well beyond lifestyle changes. Current therapeutic options carry certain health risks and are accompanied by inconveniences, particularly in the context of more invasive interventions. Consequently, research of new treatments has expanded to explore the potential of compounds naturally produced by organisms. Within these natural products, chlorophyll derivatives have sparked the interest of the scientific community. owing to the recent discovery of their lipid-reducing activity, specifically the compounds 132-hydroxy-pheophytin a e 132-hydroxy-pheofarnesin a.In this study, an optimisation of the extraction process of chlorophyll a and its derivatives was test from Arthrospira platensis biomass, a remarkable cyanobacterium that produces significant quantities of this pigment and other natural products of interest. The obtained extracts were evaluated for their lipid and appetite-reducing activities in zebrafish larvae performing the Nile Red fat metabolism bioassay and a liposome-based bioassay. Additionally, an in silicometabolomic analysis was conducted using the Global Natural Product Social Molecular Networking (GNPS) platform and relative quantification of selected chlorophyll a derivatives from liquid chromatography-mass spectrometry analyses. This approach allowed the establishment of a relationship between the extraction conditions and the relative abundances of the selected analysed compounds, the identification of bioactive extracts, and ultimately the putatively identification of compounds in these extracts.As a result, 28 extracts were obtained, with 9 of them demonstrating the ability to promote lipid reduction and 4 extracts reducing appetite in zebrafish larvae. Additionally, 9 compounds were putatively identified in some bioactive extracts and extraction protocols were developed for different derivatives of chlorophyll a.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798383771310Subjects--Topical Terms:

560998
Public health.
Index Terms--Genre/Form:

554714
Electronic books.

Chlorophyll Derivatives With Anti-Obesity Activity.
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504 $a Includes bibliographical references
520 $a Obesity represents a complex and multifactorial disease that affects a growing segment of the global population. It is linked to a spectrum of cardiovascular and psychological diseases, among others. Addressing this multifactorial disease extends well beyond lifestyle changes. Current therapeutic options carry certain health risks and are accompanied by inconveniences, particularly in the context of more invasive interventions. Consequently, research of new treatments has expanded to explore the potential of compounds naturally produced by organisms. Within these natural products, chlorophyll derivatives have sparked the interest of the scientific community. owing to the recent discovery of their lipid-reducing activity, specifically the compounds 132-hydroxy-pheophytin a e 132-hydroxy-pheofarnesin a.In this study, an optimisation of the extraction process of chlorophyll a and its derivatives was test from Arthrospira platensis biomass, a remarkable cyanobacterium that produces significant quantities of this pigment and other natural products of interest. The obtained extracts were evaluated for their lipid and appetite-reducing activities in zebrafish larvae performing the Nile Red fat metabolism bioassay and a liposome-based bioassay. Additionally, an in silicometabolomic analysis was conducted using the Global Natural Product Social Molecular Networking (GNPS) platform and relative quantification of selected chlorophyll a derivatives from liquid chromatography-mass spectrometry analyses. This approach allowed the establishment of a relationship between the extraction conditions and the relative abundances of the selected analysed compounds, the identification of bioactive extracts, and ultimately the putatively identification of compounds in these extracts.As a result, 28 extracts were obtained, with 9 of them demonstrating the ability to promote lipid reduction and 4 extracts reducing appetite in zebrafish larvae. Additionally, 9 compounds were putatively identified in some bioactive extracts and extraction protocols were developed for different derivatives of chlorophyll a.
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