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The Effects of Osteocyte-Intrinsic TGF-Beta Signaling in Alveolar Bone During Orthodontic Tooth Movement.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	The Effects of Osteocyte-Intrinsic TGF-Beta Signaling in Alveolar Bone During Orthodontic Tooth Movement./
Author:	Ngo, Albert.
Description:	1 online resource (71 pages)
Notes:	Source: Masters Abstracts International, Volume: 84-12.
Contained By:	Masters Abstracts International84-12.
Subject:	Dentistry. -
Online resource:	click for full text (PQDT)
ISBN:	9798379620653

The Effects of Osteocyte-Intrinsic TGF-Beta Signaling in Alveolar Bone During Orthodontic Tooth Movement.
Ngo, Albert.

The Effects of Osteocyte-Intrinsic TGF-Beta Signaling in Alveolar Bone During Orthodontic Tooth Movement. - 1 online resource (71 pages)

Source: Masters Abstracts International, Volume: 84-12.

Thesis (M.S.)--University of California, San Francisco, 2023.

Includes bibliographical references

Orthodontics is a specialty of dentistry that focuses on the correction of malpositioned teeth and jaws through dentofacial orthopedics. Thus, a critical understanding of tooth movement, retention, and relapse is crucial for clinical practice and treatment advancements for our patients. The foundation of orthodontic tooth movement (OTM) and relapse must be studied at the cellular level, by examining the role of osteocytes, the key cell present in bone. Many studies have explored the mechanisms underlying OTM and relapse but have focused more on the roles of osteoclasts and osteoblasts. Recent studies are now investigating osteocytes and unveiled that these cells are integral in mechanical-sensing in bone. On the molecular level, one of the pathways that is warranting further investigation is TGF-s signaling in osteocytes with respect to orthodontic tooth movement. Studies showing that osteocytes directly remodel their perilacunar/canalicular matrix suggest that TGF-s controls bone quality through this remodeling as well. TGF-s has also been shown to stimulate osteocytes to increase RANKL production, ultimately leading to osteoclastogenesis in long bones. The aim of this study was to determine the extent to which osteocyte-intrinsic TGF-s signaling in alveolar bone affects orthodontic tooth movement rate and alveolar bone remodeling. We employed TβRIIocy-/- mice to examine the mechanism of TGF-β signaling in osteocytes. TβRIIocy-/- and control littermates underwent OTM for 14 days through a spring assembly mesializing the upper left first molar. MicroCT scanning was used to measure factors such as orthodontic tooth movement rate, bone volume bone mineral density, alveolar bone height, root length, and root volume. The goal of this project was to analyze osteocyte function during orthodontic tooth movement and understand its mechanism so that we can safely and efficiently move teeth while reducing dental relapse potential afterwards. Thus, we can spark future clinical applications in orthodontic treatment and efficiency.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798379620653Subjects--Topical Terms:

674038
Dentistry.
Subjects--Index Terms:

OrthodonticsIndex Terms--Genre/Form:

554714
Electronic books.

The Effects of Osteocyte-Intrinsic TGF-Beta Signaling in Alveolar Bone During Orthodontic Tooth Movement.
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