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Molecular theory of fluctuation in life phenomena

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Molecular theory of fluctuation in life phenomena/ by Fumio Hirata.
作者:	Hirata, Fumio.
出版者:	Singapore :Springer Nature Singapore : : 2025.,
面頁冊數:	x, 146 p. :ill. (some col.), digital ; : 24 cm.;
Contained By:	Springer Nature eBook
標題:	Enzymology. -
電子資源:	https://doi.org/10.1007/978-981-96-3364-7
ISBN:	9789819633647

Molecular theory of fluctuation in life phenomena
Hirata, Fumio.

Molecular theory of fluctuation in life phenomena[electronic resource] /by Fumio Hirata. - Singapore :Springer Nature Singapore :2025. - x, 146 p. :ill. (some col.), digital ;24 cm.

Introduction -- Phenomenological description -- Statistical mechanics of molecular liquids -- Irreversible statistical mechanics of molecular liquids -- Conformational and density fluctuation in biomolecular system -- Chemical reactions of biomolecules in solutions -- Transitions among equilibrium states driven by fluctuations.

This book describes molecular processes taking place in living cells, in which "water" or "solvation" play essential roles. The molecular processes include conformational stability, fluctuation, relaxation, self-organization, molecular recognition, and chemical reactions. In all those processes, so-called solvation free-energy, and its first and second derivatives with respect to the atomic coordinates of biomolecules play key roles. Such derivatives of the free energy may not be calculated by any method of molecular simulation, because the calculation requires an analytical formula of the solvation free energy as a function of the atomic coordinates of a biomolecule. In this book, the theory is applied to analyze phenomena closely related to the conformational and density fluctuation of biomolecular systems, including the entropy and spectroscopy of both biomolecules and solvents. The theory is further developed to give microscopic expressions to the well-regarded phenomenological theories of chemical reactions, including the Michaelis-Menten theory of the enzymatic reaction, and the theory of the electron-transfer reaction by R. Marcus. Also clarified in the book is physical basis of Anfinsen's hypothesis concerning the protein folding. This book is beneficial for graduate students and researchers in the field of life science and technology, especially for those studying pharmaceutical design and biomimetic technology such as artificial enzymes.

ISBN: 9789819633647

Standard No.: 10.1007/978-981-96-3364-7doiSubjects--Topical Terms:

782178
Enzymology.

LC Class. No.: QH506

Dewey Class. No.: 572.8

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