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Foundations of comparative genomics

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Foundations of comparative genomics/ Arcady R. Mushegian.
Author:	Mushegian, Arcady R.
Published:	Amsterdam ;Academic Press, : c2007.,
Description:	ix, 265 p. :ill. ; : 27 cm.;
Subject:	Sequence Analysis - methods. -
Online resource:	An electronic book accessible through the World Wide Web; click for information
Online resource:	http://www.loc.gov/catdir/toc/ecip079/2007003418.html
Online resource:	http://www.loc.gov/catdir/enhancements/fy0707/2007003418-d.html
ISBN:	9780120887941

Foundations of comparative genomics
Mushegian, Arcady R.

Foundations of comparative genomics[electronic resource] /Arcady R. Mushegian. - Amsterdam ;Academic Press,c2007. - ix, 265 p. :ill. ;27 cm.

Includes bibliographical references (p. 238-257) and index.

The beginning of computational genomics -- Finding sequence similarities -- Homology: can we get it right? -- Getting ready for the era of comparative genomics: the importance of viruses -- The first fact of comparative genomics: protein sequences are remarkably resilient in evolution -- The second fact of comparative genomics: functional convergence at the molecular level -- Prediction of function and reconstruction of metabolism from genomic data: homology-based approaches -- Prediction of function and reconstruction of metabolism: post-homology approaches -- Structural genomics: what does it tell us about life? -- How many protein families are there? -- Phylogenetic inference and the era of complete genomes -- Two stories about evolution -- Minimal and ancestral genomes -- Comparative genomics and systems biology.

This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several state-of-the-art issues, such as systems biology and whole-genome phylogenetic reconstructions. This book is an essential reference for researchers and students in computational biology, evolutionary biology, and genetics. * Presents an historic overview of genome biology and its achievements * Includes topics not covered in other books such as minimal and ancestral genomes * Discusses the evolutionary resilience of protein-coding genes and frequent functional convergence at the molecular level * Critically reviews horizontal gene transfer and other contentious issues * Covers comparative virology as a somewhat overlooked foundation of modern genome science.

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2007.

Mode of access: World Wide Web.

ISBN: 9780120887941

Source: 112454:112542Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

655036
Sequence Analysis
--methods.Index Terms--Genre/Form:

554714
Electronic books.

LC Class. No.: QH447 / .M88 2007eb

Dewey Class. No.: 572.8/6

National Agricultural Library Call No.: QH447 / .M88 2007

National Library of Medicine Call No.: QU 58.5 / M987f 2007

Foundations of comparative genomics
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100 1 $a Mushegian, Arcady R. $3 655035
245 1 0 $a Foundations of comparative genomics $h [electronic resource] / $c Arcady R. Mushegian.
260 $a Amsterdam ; $a Boston : $c c2007. $b Academic Press,
300 $a ix, 265 p. : $b ill. ; $c 27 cm.
504 $a Includes bibliographical references (p. 238-257) and index.
505 0 $a The beginning of computational genomics -- Finding sequence similarities -- Homology: can we get it right? -- Getting ready for the era of comparative genomics: the importance of viruses -- The first fact of comparative genomics: protein sequences are remarkably resilient in evolution -- The second fact of comparative genomics: functional convergence at the molecular level -- Prediction of function and reconstruction of metabolism from genomic data: homology-based approaches -- Prediction of function and reconstruction of metabolism: post-homology approaches -- Structural genomics: what does it tell us about life? -- How many protein families are there? -- Phylogenetic inference and the era of complete genomes -- Two stories about evolution -- Minimal and ancestral genomes -- Comparative genomics and systems biology.
520 $a This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several state-of-the-art issues, such as systems biology and whole-genome phylogenetic reconstructions. This book is an essential reference for researchers and students in computational biology, evolutionary biology, and genetics. * Presents an historic overview of genome biology and its achievements * Includes topics not covered in other books such as minimal and ancestral genomes * Discusses the evolutionary resilience of protein-coding genes and frequent functional convergence at the molecular level * Critically reviews horizontal gene transfer and other contentious issues * Covers comparative virology as a somewhat overlooked foundation of modern genome science.
533 $a Electronic reproduction. $b Amsterdam : $c Elsevier Science & Technology, $d 2007. $n Mode of access: World Wide Web. $n System requirements: Web browser. $n Title from title screen (viewed on Aug. 2, 2007). $n Access may be restricted to users at subscribing institutions.
650 2 2 $a Sequence Analysis $x methods. $3 655036
650 2 2 $a Genetic Techniques. $3 582929
650 1 2 $a Genomics $x methods. $3 581355
650 0 $a Physiology, Comparative. $3 591918
650 0 $a Gene mapping. $3 582865
650 0 $a Genomics. $3 578973
655 7 $a Electronic books. $2 local $3 554714
710 2 $a ScienceDirect (Online service) $3 636041
856 4 0 $3 ScienceDirect $u http://www.sciencedirect.com/science/book/9780120887941 $z An electronic book accessible through the World Wide Web; click for information
856 4 1 $3 Table of contents only $u http://www.loc.gov/catdir/toc/ecip079/2007003418.html
856 4 2 $3 Publisher description $u http://www.loc.gov/catdir/enhancements/fy0707/2007003418-d.html
994 $a C0 $b TEF