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Handbook of process chromatography = development, manufacturing, validation and economics.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Handbook of process chromatography/
Reminder of title:	development, manufacturing, validation and economics.
Author:	Hagel, Lars.
other author:	Sofer, G. K.
Published:	London ;Academic, : 2008.,
Description:	xvi, 363 p. :ill. ; : 24 cm. +; 1 CD-ROM. +
Notes:	Previous ed.: published as by G.K. Sofer and Lars Hagel. 1997.
Subject:	Chromatographic analysis - Industrial applications. -
Online resource:	An electronic book accessible through the World Wide Web; click for information
ISBN:	9780123740236

Handbook of process chromatography = development, manufacturing, validation and economics.
Hagel, Lars.

Handbook of process chromatographydevelopment, manufacturing, validation and economics.[electronic resource] : - 2nd ed. / - London ;Academic,2008. - xvi, 363 p. :ill. ;24 cm. +1 CD-ROM.

Previous ed.: published as by G.K. Sofer and Lars Hagel. 1997.

Includes bibliographical references and index.

Preface -- Acknowledgements -- 1. Biopharmaceuticals Today -- 2. Process Capability and Production Scenarios -- 3. Process Design Concepts -- 4. Separation Technologies -- 5. Analysis -- 6. Cleaning and Sanitization -- 7. Validation -- 8. Economics -- 9. Basic Properties of Peptides, Proteons, Nucleic Acids, and Virus Particles -- 10. Optimization of Chromatographic Separations -- 11. Equipment -- 12. Column Packing -- Appendix A. Symbols and Definitions in Liquid Chromatography -- Appendix B. Dimensionless Numbers -- Appendix C. Activities for Biopharmaceutical Production from Genetically Engineered Mammalian Cells -- Appendix D. Simulations Using the Supplied Software.

This book will update the original edition published in 1997. Since the publication of the first edition, the biotechnology and biologics industries have gained extensive knowledge and experience in downstream processing using chromatography and other technologies associated with recovery and purification unit operations. This book will tie that experience together for the next generation of readers. Updates include: - sources and productivity - types of products made today - experiences in clinical and licensed products - economics - current status of validation - illustrations and tables - automated column packing - automated systems New topics include: - the use of disposables - multiproduct versus dedicated production - design principles for chromatography media and filters - ultrafiltration principles and optimization - risk assessments - characterization studies - design space - platform technologies - process analytical technologies (PATs) - biogenerics - comparability assessments Key Features: - new approaches to process optimiaztion - use of patform technologies - applying risk assessment to process design.

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2008.

Mode of access: World Wide Web.

ISBN: 9780123740236

Source: 139276:139413Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

655191
Chromatographic analysis
--Industrial applications.Index Terms--Genre/Form:

554714
Electronic books.

LC Class. No.: QD79.C4 / H34 2008eb

Dewey Class. No.: 543.8

Handbook of process chromatography = development, manufacturing, validation and economics.
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245 1 0 $a Handbook of process chromatography $h [electronic resource] : $b development, manufacturing, validation and economics.
250 $a 2nd ed. / $b Lars Hagel, G�unter Jagschies and Gail Sofer.
260 $a London ; $a Burlington, MA : $c 2008. $b Academic,
300 $a xvi, 363 p. : $b ill. ; $c 24 cm. + $e 1 CD-ROM.
500 $a Previous ed.: published as by G.K. Sofer and Lars Hagel. 1997.
500 $a Includes CD-ROM.
504 $a Includes bibliographical references and index.
505 0 $a Preface -- Acknowledgements -- 1. Biopharmaceuticals Today -- 2. Process Capability and Production Scenarios -- 3. Process Design Concepts -- 4. Separation Technologies -- 5. Analysis -- 6. Cleaning and Sanitization -- 7. Validation -- 8. Economics -- 9. Basic Properties of Peptides, Proteons, Nucleic Acids, and Virus Particles -- 10. Optimization of Chromatographic Separations -- 11. Equipment -- 12. Column Packing -- Appendix A. Symbols and Definitions in Liquid Chromatography -- Appendix B. Dimensionless Numbers -- Appendix C. Activities for Biopharmaceutical Production from Genetically Engineered Mammalian Cells -- Appendix D. Simulations Using the Supplied Software.
520 $a This book will update the original edition published in 1997. Since the publication of the first edition, the biotechnology and biologics industries have gained extensive knowledge and experience in downstream processing using chromatography and other technologies associated with recovery and purification unit operations. This book will tie that experience together for the next generation of readers. Updates include: - sources and productivity - types of products made today - experiences in clinical and licensed products - economics - current status of validation - illustrations and tables - automated column packing - automated systems New topics include: - the use of disposables - multiproduct versus dedicated production - design principles for chromatography media and filters - ultrafiltration principles and optimization - risk assessments - characterization studies - design space - platform technologies - process analytical technologies (PATs) - biogenerics - comparability assessments Key Features: - new approaches to process optimiaztion - use of patform technologies - applying risk assessment to process design.
533 $a Electronic reproduction. $b Amsterdam : $c Elsevier Science & Technology, $d 2008. $n Mode of access: World Wide Web. $n System requirements: Web browser. $n Title from title screen (viewed on May 14, 2008). $n Access may be restricted to users at subscribing institutions.
650 0 $a Chromatographic analysis $x Industrial applications. $3 655191
655 7 $a Electronic books. $2 local $3 554714
700 1 $a Sofer, G. K. $3 583538
700 1 $a Jagschies, G�unter. $3 655192
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856 4 0 $3 ScienceDirect $u http://www.sciencedirect.com/science/book/9780123740236 $z An electronic book accessible through the World Wide Web; click for information
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