國立虎尾科技大學 |

New transcription factors and their role in diabetes and therapy

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	New transcription factors and their role in diabetes and therapy/ editor, Jacob E. Friedman.
其他作者:	Friedman, Jacob E.
出版者:	Amsterdam ;Elsevier, : 2006.,
面頁冊數:	xii, 309 p. :ill. :
標題:	Diabetes Mellitus, Type 2. -
電子資源:	http://www.sciencedirect.com/science/book/9780444511584
ISBN:	9780444511584

New transcription factors and their role in diabetes and therapy
New transcription factors and their role in diabetes and therapy[electronic resource] /editor, Jacob E. Friedman. - 1st ed. - Amsterdam ;Elsevier,2006. - xii, 309 p. :ill. - Advances in molecular and cellular endocrinology ;v. 5. - Advances in molecular and cellular endocrinology ;v. 5..

Includes bibliographical references and index.

1. PPARs as therapeutic targets for treating diabetes and insulin resistance -- 2. Genetic regulators of human obesity and diabetes -- 3. NF-kb, insulin resistance and the actions of salicylates -- 4. Wnt signaling and C/EBPs role in adipogenesis -- 5. Regulation of hepatic gluconeogenesis C/EPBs -- 6. Forkhead proteins and regulation of hepatic gene expression -- 7. Control of mitochondrial biogenesis through PGC-1 -- 8. Regulation of PGC-1 in humans in insulin resistance and diabetes: Functional implications -- 9. FOXC2 controls resistance to obesity and Type II diabetes -- 10. SREB-1C regulation of nutrient homeostasis and lipid accumulation -- 11. GATA proteins as molecular gatekeeprs of the adipocyte -- 12. Diabetes regulation of gene expression by CREB -- 13. Molecular etiologies of MODY and other early-onset forms of diabetes -- 14. Liver X receptors as potential drug targets for Diabetes and its disorders -- 15. The potential therapeutic use of PPAR beta/delta agonists in lipid and glucose homeostasis -- 16. Influences of new PPAR insulin sensitizers on the metabolic syndrome in Rhesus Monkeys -- 17. PPARgamma and metabolism: Insights from the study of human genetic variants.

This book contains contributions from some of the most eminent experts in the fields of genetics, biochemistry, and pathophysiology of diabetes. Through specific examples, with broad applications, this book provides a comprehensive look at how transcription factors may underline the pathogenetic mechanisms of diabetes and obesity. Volume 5 provides an overview of the status of the field, while also providing valuable information of practical utility to those who do not necessarily work in this field. The integration of basic biology with physiologically and clinically relevant proteins should provide the reader with a theoretical background to understanding the strategies for new potential therapeutic targets and their application to disease. *Applies molecular biology to transcriptional regulation of metabolism and obesity *Underscores the clinical relevance of transcription factors *Provides a valuable overview of the current status of the field.

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2007.

Mode of access: World Wide Web.

ISBN: 9780444511584

Source: 109762:109810Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

778232
Diabetes Mellitus, Type 2.
Index Terms--Genre/Form:

554714
Electronic books.

LC Class. No.: QP187.3.M64 / A38 v.5eb

Dewey Class. No.: 616.46207

National Library of Medicine Call No.: W1 / AD6823 v.5 2006

New transcription factors and their role in diabetes and therapy
LDR:05390cam 2200397Ia 4500 001 679446
003 OCoLC
005 20110614113917.0
006 m d
007 cr cn|||||||||
008 111108s2006 ne a ob 001 0 eng d
020 $a 9780444511584
020 $a 044451158X
029 1 $a NZ1 $b 12434453
029 1 $a CHVBK $b 135303672
035 $a (OCoLC)162130225
035 $a ocn162130225
037 $a 109762:109810 $b Elsevier Science & Technology $n http://www.sciencedirect.com
040 $a OPELS $c OPELS $d BAKER $d OPELS
049 $a TEFA
050 1 4 $a QP187.3.M64 $b A38 v.5eb
060 1 4 $a W1 $b AD6823 v.5 2006
060 1 4 $a WK 810 $b N5329 2006
082 0 4 $a 616.46207 $2 22
245 0 0 $a New transcription factors and their role in diabetes and therapy $h [electronic resource] / $c editor, Jacob E. Friedman.
250 $a 1st ed.
260 $a Amsterdam ; $a Boston : $b Elsevier, $c 2006.
300 $a xii, 309 p. : $b ill.
490 1 $a Advances in molecular and cellular endocrinology ; $v v. 5
504 $a Includes bibliographical references and index.
505 0 $a 1. PPARs as therapeutic targets for treating diabetes and insulin resistance -- 2. Genetic regulators of human obesity and diabetes -- 3. NF-kb, insulin resistance and the actions of salicylates -- 4. Wnt signaling and C/EBPs role in adipogenesis -- 5. Regulation of hepatic gluconeogenesis C/EPBs -- 6. Forkhead proteins and regulation of hepatic gene expression -- 7. Control of mitochondrial biogenesis through PGC-1 -- 8. Regulation of PGC-1 in humans in insulin resistance and diabetes: Functional implications -- 9. FOXC2 controls resistance to obesity and Type II diabetes -- 10. SREB-1C regulation of nutrient homeostasis and lipid accumulation -- 11. GATA proteins as molecular gatekeeprs of the adipocyte -- 12. Diabetes regulation of gene expression by CREB -- 13. Molecular etiologies of MODY and other early-onset forms of diabetes -- 14. Liver X receptors as potential drug targets for Diabetes and its disorders -- 15. The potential therapeutic use of PPAR beta/delta agonists in lipid and glucose homeostasis -- 16. Influences of new PPAR insulin sensitizers on the metabolic syndrome in Rhesus Monkeys -- 17. PPARgamma and metabolism: Insights from the study of human genetic variants.
505 0 $a Transcription factor genes in type 2 diabetes / by M.N. Weedon, A.T. Hattersley & T.M. Frayling -- PPAR[gamma], a key therapeutic target in the metabolic syndrome-unique insights derived from the study of human genetic variants / by C.S. Mitchell & M. Gurnell -- PPAR[delta]: emerging therapeutic potential of novel agonists in lipid and glucose homeostasis / by U. Dressel & G.E.O. Muscat -- Liver X receptors as potential drug targets for diabetes and its disorders / by K.R. Steffenson -- SREBP-lc regulation of nutrient homeostasis and lipid accumulation / by P. Ferr�e ... [et al.] -- The adipocyte and adipose tissue as endocrine organs: impact on the insulin resistance phenotype / by R.R. Henry ... [et al.] -- FOXC2 in the adipocyte / by S. Enerb�ack -- Regulation of adipocyte differentiation and metabolism by Wnt signaling and C/EBP transcription factors / by I. Gerin, H.D. Cha & O.A. MacDougald -- GATA proteins as molecular gatekeepers of adipogenesis / by J. Tsai, Q. Tong & G.S. Hotamisligil -- Forkhead proteins and the regulation of hepatic gene expression / by A. Barthel, S. Herzig & D. Schmoll -- Disruption of CREB regulated of gene expression in diabetes / by J.E.B. Reusch, P.A. Watson & S. Pugazhenthi -- Regulation of PGC-1 in humans with insulin resistance and type 2 diabetes: functional implications / by J. Pihlajam�aki & M.E. Patti -- Hepatic CCAAT/enhancer binding protein [beta] (C/EBP[beta]): engineer of diabetes, obesity, and inflammatory disease processes / by J.M. Schroeder-Gloeckler, S.M. Rahman & J.E. Friedman -- Insulin resistance, inflammation, and the IKK/I[kappa]B/NF-[kappa]B pathway by B.A. Bhatt & R.M. O'Doherty.
520 $a This book contains contributions from some of the most eminent experts in the fields of genetics, biochemistry, and pathophysiology of diabetes. Through specific examples, with broad applications, this book provides a comprehensive look at how transcription factors may underline the pathogenetic mechanisms of diabetes and obesity. Volume 5 provides an overview of the status of the field, while also providing valuable information of practical utility to those who do not necessarily work in this field. The integration of basic biology with physiologically and clinically relevant proteins should provide the reader with a theoretical background to understanding the strategies for new potential therapeutic targets and their application to disease. *Applies molecular biology to transcriptional regulation of metabolism and obesity *Underscores the clinical relevance of transcription factors *Provides a valuable overview of the current status of the field.
533 $a Electronic reproduction. $b Amsterdam : $c Elsevier Science & Technology, $d 2007. $n Mode of access: World Wide Web. $n System requirements: Web browser. $n Title from title screen (viewed on July 25, 2007). $n Access may be restricted to users at subscribing institutions.
650 1 2 $a Diabetes Mellitus, Type 2. $3 778232
650 1 2 $a Transcription Factors. $3 654974
650 2 2 $a Diabetes Mellitus, Type 2 $x genetics. $3 788438
650 2 2 $a Diabetes Mellitus, Type 2 $x physiopathology. $3 582759
650 0 $a Transcription factors. $3 654971
650 0 $a Diabetes $x Genetic factors. $3 788439
650 0 $a Diabetes $x Pathophysiology. $3 679778
650 6 $a Diab�ete $x Physiopathologie. $3 788440
650 6 $a Facteurs de transcription. $3 788441
650 6 $a Ob�esit� $x Physiopathologie. $3 788442
655 7 $a Electronic books. $2 local $3 554714
700 1 $a Friedman, Jacob E. $3 788436
710 2 $a ScienceDirect (Online service) $3 636041
830 0 $a Advances in molecular and cellular endocrinology ; $v v. 5. $3 788437
856 4 0 $3 ScienceDirect $u http://www.sciencedirect.com/science/book/9780444511584
938 $a Baker & Taylor $b BKTY $c 139.95 $d .00 $i 044451158X $n 0006308408 $s active
994 $a C0 $b TEF