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Target validation in drug discovery

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Target validation in drug discovery/ editors, Brian W. Metcalf and Susan Dillon.
other author:	Metcalf, Brian W.
Published:	Amsterdam ;Academic Press, : c2007.,
Description:	xii, 279 p. :ill. ; : 27 cm.;
Subject:	Drug development. -
Online resource:	An electronic book accessible through the World Wide Web; click for information
ISBN:	9780123693938

Target validation in drug discovery
Target validation in drug discovery[electronic resource] /editors, Brian W. Metcalf and Susan Dillon. - Amsterdam ;Academic Press,c2007. - xii, 279 p. :ill. ;27 cm.

Includes bibliographical references and index.

Section Contents -- I. Pharmaceutical Biotechnology for Target Validation -- II. Target Validation for Biopharmaceutical Drug Discovery -- III. Validating Targets of Small Molecule Approaches.

This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2007.

Mode of access: World Wide Web.

ISBN: 9780123693938

Source: 113098:113186Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

581824
Drug development.
Index Terms--Genre/Form:

554714
Electronic books.

LC Class. No.: RM301.63 / .T36 2007eb

Dewey Class. No.: 615/.19

National Library of Medicine Call No.: 2006 N-124

Target validation in drug discovery
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245 0 0 $a Target validation in drug discovery $h [electronic resource] / $c editors, Brian W. Metcalf and Susan Dillon.
260 $a Amsterdam ; $a Boston : $b Academic Press, $c c2007.
300 $a xii, 279 p. : $b ill. ; $c 27 cm.
504 $a Includes bibliographical references and index.
505 0 $a Section Contents -- I. Pharmaceutical Biotechnology for Target Validation -- II. Target Validation for Biopharmaceutical Drug Discovery -- III. Validating Targets of Small Molecule Approaches.
520 $a This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.
533 $a Electronic reproduction. $b Amsterdam : $c Elsevier Science & Technology, $d 2007. $n Mode of access: World Wide Web. $n System requirements: Web browser. $n Title from title screen (viewed on July 25, 2007). $n Access may be restricted to users at subscribing institutions.
650 0 $a Drug development. $3 581824
650 0 $a Drugs $x Testing. $3 581825
650 0 $a High throughput screening (Drug development) $3 582128
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650 6 $a M�edicaments $x Essais cliniques. $3 791584
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655 7 $a Electronic books. $2 local $3 554714
700 1 $a Metcalf, Brian W. $3 791581
700 1 $a Dillon, Susan, $d 1952- $3 791582
710 2 $a ScienceDirect (Online service) $3 636041
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994 $a C0 $b TEF