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Extracellular matrix and the liver = approach to gene therapy /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Extracellular matrix and the liver/ edited by Isao Okazaki ... [et al.].
其他題名:	approach to gene therapy /
其他作者:	Okazaki, Isao.
團體作者:	Workshop on the Preservation of Stability under Discretization
出版者:	Amsterdam ;Academic Press, : c2003.,
面頁冊數:	1 online resource (xxi, 467 p.) :ill. :
標題:	Liver - Cirrhosis -
電子資源:	http://www.sciencedirect.com/science/book/9780125252515
ISBN:	9780125252515

Extracellular matrix and the liver = approach to gene therapy /
Extracellular matrix and the liverapproach to gene therapy /[electronic resource] :edited by Isao Okazaki ... [et al.]. - Amsterdam ;Academic Press,c2003. - 1 online resource (xxi, 467 p.) :ill.

Includes bibliographical references and index.

New Insights into the Extracellular Matrix. -- Dynamic Regulation of Basement Membrane Collagen IV Gene Expression in Malignant Tumors. -- Regulation of Phenotypes of Human AortaEndothelial Cells and Smooth Muscle Cells in Culture by Type IV Collage Aggregates. -- Functions of Proteoglycan/Glycosaminoglycan in Liver; SPARC, A Matricellular Protein that Regulates Cell-Matrix Interaction: Implications for Vascular and Connective Tissue Biology. -- Cells Responsible for ECM Production in the Liver. Different Hepatic Cell Populations of the Fibroblast Lineage with Fibrogenic Potential. -- Role of Sinusoidal Endothelial Cells in Liver Inflammation and Repair. -- Molecular Mechanism of Stellate Cell Activation and ECM Remodeling. -- Role of Histone Deacetylases in Transcriptional Control of the Hepatic Stellate Cell Phenotype. Knockout Mice of Matrix Metalloproteinase Genes. Stem Cells Expressing MMP-13 mRNA Appear During Regression Reversal of Hepatic Cirrhosis.

Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discusses new strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapy approaches. The chapters are divided into six sections as follows: * Basic Science of Extracellular Matrix * Cells Responsible for Extracellular Matrix Production * Activation Mechanism of Hepatic Cells and Signal Transduction * Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors * Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases * New Strategies for the treatment of Liver Cirrhosis Key Features * Discusses the possibility of gene therapy for liver cirrhosis * Includes information on new aspects of hepatic stellate cells * Written by top experts in basic science and clinical hepatology.

ISBN: 9780125252515

Source: 90519:90519Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

862457
Liver
--CirrhosisIndex Terms--Genre/Form:

554714
Electronic books.

LC Class. No.: RC848.C5 / E96 2003eb

Dewey Class. No.: 616.362406

National Library of Medicine Call No.: 2003 D-810

Extracellular matrix and the liver = approach to gene therapy /
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505 0 $a New Insights into the Extracellular Matrix. -- Dynamic Regulation of Basement Membrane Collagen IV Gene Expression in Malignant Tumors. -- Regulation of Phenotypes of Human AortaEndothelial Cells and Smooth Muscle Cells in Culture by Type IV Collage Aggregates. -- Functions of Proteoglycan/Glycosaminoglycan in Liver; SPARC, A Matricellular Protein that Regulates Cell-Matrix Interaction: Implications for Vascular and Connective Tissue Biology. -- Cells Responsible for ECM Production in the Liver. Different Hepatic Cell Populations of the Fibroblast Lineage with Fibrogenic Potential. -- Role of Sinusoidal Endothelial Cells in Liver Inflammation and Repair. -- Molecular Mechanism of Stellate Cell Activation and ECM Remodeling. -- Role of Histone Deacetylases in Transcriptional Control of the Hepatic Stellate Cell Phenotype. Knockout Mice of Matrix Metalloproteinase Genes. Stem Cells Expressing MMP-13 mRNA Appear During Regression Reversal of Hepatic Cirrhosis.
520 $a Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discusses new strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapy approaches. The chapters are divided into six sections as follows: * Basic Science of Extracellular Matrix * Cells Responsible for Extracellular Matrix Production * Activation Mechanism of Hepatic Cells and Signal Transduction * Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors * Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases * New Strategies for the treatment of Liver Cirrhosis Key Features * Discusses the possibility of gene therapy for liver cirrhosis * Includes information on new aspects of hepatic stellate cells * Written by top experts in basic science and clinical hepatology.
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