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Models of protection against HIV/SIV = avoiding AIDS in humans and monkeys /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Models of protection against HIV/SIV/ edited by Gianfranco Pancino, Guido Silvestri, Keith Fowke.
Reminder of title:	avoiding AIDS in humans and monkeys /
other author:	Pancino, Gianfranco.
Published:	London ;Academic Press, : 2012.,
Description:	1 online resource (xiv, 345 p.)
Subject:	HIV Infections - immunology. -
Online resource:	An electronic book accessible through the World Wide Web; click for information
ISBN:	9780123877154 (electronic bk.)

Models of protection against HIV/SIV = avoiding AIDS in humans and monkeys /
Models of protection against HIV/SIVavoiding AIDS in humans and monkeys /[electronic resource] :edited by Gianfranco Pancino, Guido Silvestri, Keith Fowke. - 1st ed. - London ;Academic Press,2012. - 1 online resource (xiv, 345 p.)

Simian models of non-pathogenic -- SIV infection -- Natural SIV infection: virological aspects -- Natural SIV infection: immunological aspects -- Prevention Implications for therapy HIV-1-exposed seronegative individuals -- Are some people protected against HIV infection? -- The genital mucosa, the front lines in the defense against HIV -- Host genetics and resistance to HIV-1 infection -- The immune system and resisting HIV infection -- HIV-1-controllers -- Definition, natural history and heterogeneity of HIV-controllers -- Residual viremia and viral reservoirs in elite controllers Immune responses associated to viral control Immune mechanisms of viral control in HIV-2 infection -- Genetic basis of protection against HIV -- Genetic associations with resistance to HIV-1 infection, viral control and protection against disease.

A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barér-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field.

ISBN: 9780123877154 (electronic bk.)

Source: 1103697:10970221Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

862575
HIV Infections
--immunology.Index Terms--Genre/Form:

554714
Electronic books.

LC Class. No.: RA644.A25 / M63 2012eb

Dewey Class. No.: 616.979205

National Library of Medicine Call No.: WC 503

Models of protection against HIV/SIV = avoiding AIDS in humans and monkeys /
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245 0 0 $a Models of protection against HIV/SIV $h [electronic resource] : $b avoiding AIDS in humans and monkeys / $c edited by Gianfranco Pancino, Guido Silvestri, Keith Fowke.
250 $a 1st ed.
260 $a London ; $a Waltham, MA : $b Academic Press, $c 2012.
300 $a 1 online resource (xiv, 345 p.)
505 0 $a Simian models of non-pathogenic -- SIV infection -- Natural SIV infection: virological aspects -- Natural SIV infection: immunological aspects -- Prevention Implications for therapy HIV-1-exposed seronegative individuals -- Are some people protected against HIV infection? -- The genital mucosa, the front lines in the defense against HIV -- Host genetics and resistance to HIV-1 infection -- The immune system and resisting HIV infection -- HIV-1-controllers -- Definition, natural history and heterogeneity of HIV-controllers -- Residual viremia and viral reservoirs in elite controllers Immune responses associated to viral control Immune mechanisms of viral control in HIV-2 infection -- Genetic basis of protection against HIV -- Genetic associations with resistance to HIV-1 infection, viral control and protection against disease.
520 $a A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barér-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field.
588 $a Description based on print version record.
650 1 2 $a HIV Infections $x immunology. $3 862575
650 1 2 $a HIV Infections $x prevention & control. $3 862576
650 2 2 $a Disease Models, Animal. $3 582981
650 2 2 $a HIV $x immunology. $3 862577
650 2 2 $a Simian Acquired Immunodeficiency Syndrome $x immunology. $3 862578
650 0 $a HIV infections $x Prevention. $3 807525
650 0 $a Vaccines $x Testing. $3 582185
655 4 $a Electronic books. $2 local $3 554714
700 1 $a Pancino, Gianfranco. $3 862572
700 1 $a Silvestri, Guido, $c MD. $3 862573
700 1 $a Fowke, Keith R. $3 862574
710 2 $a ScienceDirect (Online service) $3 636041
856 4 0 $3 ScienceDirect $u http://www.sciencedirect.com/science/book/9780123877154 $z An electronic book accessible through the World Wide Web; click for information