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Parasitic helminths DUP_1 = targets, screens, drugs and vaccines /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Parasitic helminths DUP_1/ edited by Conor R. Caffrey.
其他題名:	targets, screens, drugs and vaccines /
其他作者:	Caffrey, Conor R.
出版者:	Weinheim, Germany :Wiley-VCH, : 2012.,
面頁冊數:	1 online resource (xxiii, 516 p. :)ill. (some col.). :
標題:	Helminths. -
電子資源:	http://onlinelibrary.wiley.com/book/10.1002/9783527652969
ISBN:	9783527652969 (electronic bk.)

Parasitic helminths DUP_1 = targets, screens, drugs and vaccines /
Parasitic helminths DUP_1targets, screens, drugs and vaccines /[electronic resource] :edited by Conor R. Caffrey. - Weinheim, Germany :Wiley-VCH,2012. - 1 online resource (xxiii, 516 p. :)ill. (some col.). - Drug discovery in infectious diseases ;v. 3. - Drug discovery in infectious diseases ;v. 4..

Includes bibliographical references and index.

Part one: targets -- Ligand-gated ion channels as targets for anthelmintic drugs: past, current, and future perspectives -- How relevant is Caenorhabditis elegans as a model for the analysis of parasitic nematode biology? -- Integrating and mining helminth genomes to discover and prioritize novel therapeutic targets -- Recent progress in transcriptomics of key gastrointestinal nematodes of animals: fundamental research toward new intervention strategies -- Harnessing genomic technologies to explore the molecular biology of liver flukes-major implications for fundamental and applied research -- RNA interference: a potential discovery tool for therapeutic targets of parasitic nematodes -- RNA interference as a tool for drug discovery in parasitic flatworms -- Part two: screens -- Mechanism-based screening strategies for anthelmintic discovery -- Identification and profiling of nematicidal compounds in veterinary parasitology -- Quantitative high-content screening-based drug discovery against helmintic diseases -- Use of rodent models in the discovery of novel anthelmintics -- To kill a mocking worm: strategies to improve Caenorhabditis elegans as a model system for use in anthelmintic discovery -- Part three: drugs -- Anthelmintic drugs: tools and shortcuts for the long road from discovery to product -- Antinematodal drugs: modes of action and resistance: and worms will not come to thee (Shakespeare: Cymbeline: iv, ii) -- Drugs and targets to perturb the symbiosis of Wolbachia and filarial nematodes -- Promise of Bacillus thuringiensis crystal proteins as anthelmintics -- Monepantel: from discovery to mode of action -- Discovery, mode of action, and commercialization of derquantel -- Praziquantel: too good to be replaced? -- Drug discovery for trematodiases: challenges and progress -- Part four: vaccines -- Barefoot thru' the valley of darkness: preclinical development of a human hookworm vaccine -- Vaccines linked to chemotherapy: a new approach to control helminth infections -- Antifilarial vaccine development: present and future approaches -- Proteases as vaccines against gastrointestinal nematode parasites of sheep and cattle -- Schistosomiasis vaccines: new approaches to antigen discovery and promising new candidates -- Sm14 Schistosoma mansoni fatty acid-binding protein: molecular basis for an antihelminth vaccine -- Mechanisms of immune modulation by Fasciola hepatica: importance for vaccine development and for novel immunotherapeutics -- Prospects for immunoprophylaxis against Fasciola hepatica (liver fluke) -- Vaccines against cestode parasites.

ISBN: 9783527652969 (electronic bk.)Subjects--Topical Terms:

862636
Helminths.

LC Class. No.: RC119.7 / .P37 2012eb

Dewey Class. No.: 616.96061

Parasitic helminths DUP_1 = targets, screens, drugs and vaccines /
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245 0 0 $a Parasitic helminths DUP_1 $h [electronic resource] : $b targets, screens, drugs and vaccines / $c edited by Conor R. Caffrey.
260 $a Weinheim, Germany : $b Wiley-VCH, $c 2012.
300 $a 1 online resource (xxiii, 516 p. :) $b ill. (some col.).
490 1 $a Drug discovery in infectious diseases ; $v v. 3
504 $a Includes bibliographical references and index.
505 0 $a Part one: targets -- Ligand-gated ion channels as targets for anthelmintic drugs: past, current, and future perspectives -- How relevant is Caenorhabditis elegans as a model for the analysis of parasitic nematode biology? -- Integrating and mining helminth genomes to discover and prioritize novel therapeutic targets -- Recent progress in transcriptomics of key gastrointestinal nematodes of animals: fundamental research toward new intervention strategies -- Harnessing genomic technologies to explore the molecular biology of liver flukes-major implications for fundamental and applied research -- RNA interference: a potential discovery tool for therapeutic targets of parasitic nematodes -- RNA interference as a tool for drug discovery in parasitic flatworms -- Part two: screens -- Mechanism-based screening strategies for anthelmintic discovery -- Identification and profiling of nematicidal compounds in veterinary parasitology -- Quantitative high-content screening-based drug discovery against helmintic diseases -- Use of rodent models in the discovery of novel anthelmintics -- To kill a mocking worm: strategies to improve Caenorhabditis elegans as a model system for use in anthelmintic discovery -- Part three: drugs -- Anthelmintic drugs: tools and shortcuts for the long road from discovery to product -- Antinematodal drugs: modes of action and resistance: and worms will not come to thee (Shakespeare: Cymbeline: iv, ii) -- Drugs and targets to perturb the symbiosis of Wolbachia and filarial nematodes -- Promise of Bacillus thuringiensis crystal proteins as anthelmintics -- Monepantel: from discovery to mode of action -- Discovery, mode of action, and commercialization of derquantel -- Praziquantel: too good to be replaced? -- Drug discovery for trematodiases: challenges and progress -- Part four: vaccines -- Barefoot thru' the valley of darkness: preclinical development of a human hookworm vaccine -- Vaccines linked to chemotherapy: a new approach to control helminth infections -- Antifilarial vaccine development: present and future approaches -- Proteases as vaccines against gastrointestinal nematode parasites of sheep and cattle -- Schistosomiasis vaccines: new approaches to antigen discovery and promising new candidates -- Sm14 Schistosoma mansoni fatty acid-binding protein: molecular basis for an antihelminth vaccine -- Mechanisms of immune modulation by Fasciola hepatica: importance for vaccine development and for novel immunotherapeutics -- Prospects for immunoprophylaxis against Fasciola hepatica (liver fluke) -- Vaccines against cestode parasites.
588 $a Description based on print version record.
650 0 $a Helminths. $3 862636
650 0 $a Parasites. $3 579395
650 0 $a Parasitic diseases $x Treatment. $3 1058491
650 0 $a Parasitic diseases $x Diagnosis. $3 1060327
700 1 $a Caffrey, Conor R. $3 1060326
830 0 $a Drug discovery in infectious diseases ; $v v. 4. $3 1000296
856 4 0 $u http://onlinelibrary.wiley.com/book/10.1002/9783527652969