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Receptor tyrosine kinases = structure, functions and role in human disease /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Receptor tyrosine kinases/ edited by Deric L. Wheeler, Yosef Yarden.
其他題名:	structure, functions and role in human disease /
其他作者:	Wheeler, Deric L.
出版者:	New York, NY :Springer New York : : 2015.,
面頁冊數:	xvii, 440 p. :ill. (some col.), digital ; : 24 cm.;
Contained By:	Springer eBooks
標題:	Protein-tyrosine kinase. -
電子資源:	http://dx.doi.org/10.1007/978-1-4939-2053-2
ISBN:	9781493920532 (electronic bk.)

Receptor tyrosine kinases = structure, functions and role in human disease /
Receptor tyrosine kinasesstructure, functions and role in human disease /[electronic resource] :edited by Deric L. Wheeler, Yosef Yarden. - New York, NY :Springer New York :2015. - xvii, 440 p. :ill. (some col.), digital ;24 cm.

The Eukaryotic Protein Kinase Superfamily -- Evolution of Receptor Tyrosine Kinases -- RTKs in Invertebrates: Lessons in Signal Transduction -- Cell Signaling by Receptor Tyrosine Kinases -- Nuclear Signaling of Receptor Tyrosine Kinases -- Computational and Modeling Aspects of RTK Networks -- Endocytosis of Receptor Tyrosine Kinases -- Structural Features of the Ligand-Binding Extracellular Domain -- Structural Features of the Kinase Domain -- Targeting RTKs in Cancer.-- Mouse Models of Receptor Tyrosine Kinases.

Receptor tyrosine kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases, and over the last decade have become the number one targets of cancer drugs. Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease systematically covers, for the first time, the shared structural and functional features of the RTK family. Understanding the evolutionary origin of the 58 RTKs, their roles in invertebrates and in humans, as well as downstream signaling pathways, is essential for fundamental research and for attempts to develop pharmacological agents able to enhance or intercept their actions. The assembly of chapters written by experts underscores commonalities and is an ideal companion volume to The Receptor Tyrosine Kinase Family, which refers to specific subfamilies of RTKs, along with their unique landmarks.

ISBN: 9781493920532 (electronic bk.)

Standard No.: 10.1007/978-1-4939-2053-2doiSubjects--Topical Terms:

1063739
Protein-tyrosine kinase.

LC Class. No.: QP606.P78

Dewey Class. No.: 572.6

Receptor tyrosine kinases = structure, functions and role in human disease /
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