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BRAF targets in melanoma = biological mechanisms, resistance, and drug discovery /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	BRAF targets in melanoma/ edited by Ryan J. Sullivan.
Reminder of title:	biological mechanisms, resistance, and drug discovery /
other author:	Sullivan, Ryan J.
Published:	New York, NY :Springer New York : : 2015.,
Description:	viii, 204 p. :ill. (some col.), digital ; : 24 cm.;
Contained By:	Springer eBooks
Subject:	Melanoma - Treatment. -
Online resource:	http://dx.doi.org/10.1007/978-1-4939-2143-0
ISBN:	9781493921430 (electronic bk.)

BRAF targets in melanoma = biological mechanisms, resistance, and drug discovery /
BRAF targets in melanomabiological mechanisms, resistance, and drug discovery /[electronic resource] :edited by Ryan J. Sullivan. - New York, NY :Springer New York :2015. - viii, 204 p. :ill. (some col.), digital ;24 cm. - Cancer drug discovery and development,v.822196-9906 ;. - Cancer drug discovery and development ;v.82..

Melanoma: Historical Context -- Melanoma Pathogenesis -- Molecular Diagnostics and Tumor Mutational Analysis -- Clinical Utility of BRAF-targeted therapy in Melanoma -- The Ethics of Randomized Trials in Oncology -- Parallel and Serial Blockade Strategies in BRAF-Mutant Melanoma -- Targeting the cell cycle and p53 in combination with BRAF-directed therapy -- Combination BRAF-directed therapy and immunotherapy -- Moving Forward: Making BRAF-Targeted Therapy Better.

This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that these drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researchers who work in drug discovery, there is a lot of interest in the development of molecularly targeted cancer agents. Namely, the identification of a molecular target, the selection of molecules which effectively inhibit this target. What is starkly different about the development of this class of compounds, however, is that the mechanism of action of these agents are not as straightforward as was once previously assumed and the mechanisms of resistance that tumor cells employ to evade complete destruction are unlike any that have been described before. These discoveries in addition to utilization of modern molecular biology techniques have led to a series of hypotheses regarding which other types of molecules could be used in combination with BRAF-inhibitors in hopes of revolutionizing the potential of therapeutics in melanoma.

ISBN: 9781493921430 (electronic bk.)

Standard No.: 10.1007/978-1-4939-2143-0doiSubjects--Topical Terms:

778173
Melanoma
--Treatment.

LC Class. No.: RC280.M37 / B73 2015

Dewey Class. No.: 616.99477

BRAF targets in melanoma = biological mechanisms, resistance, and drug discovery /
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520 $a This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that these drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researchers who work in drug discovery, there is a lot of interest in the development of molecularly targeted cancer agents. Namely, the identification of a molecular target, the selection of molecules which effectively inhibit this target. What is starkly different about the development of this class of compounds, however, is that the mechanism of action of these agents are not as straightforward as was once previously assumed and the mechanisms of resistance that tumor cells employ to evade complete destruction are unlike any that have been described before. These discoveries in addition to utilization of modern molecular biology techniques have led to a series of hypotheses regarding which other types of molecules could be used in combination with BRAF-inhibitors in hopes of revolutionizing the potential of therapeutics in melanoma.
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