國立虎尾科技大學 |

Prokaryotic systems biology

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Prokaryotic systems biology/ edited by Nevan J. Krogan, Mohan Babu.
其他作者:	Babu, Mohan.
出版者:	Cham :Imprint: Springer, : 2015.,
面頁冊數:	ix, 319 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
標題:	Systems Biology. -
電子資源:	http://dx.doi.org/10.1007/978-3-319-23603-2
ISBN:	9783319236032

Prokaryotic systems biology
Prokaryotic systems biology[electronic resource] /edited by Nevan J. Krogan, Mohan Babu. - Cham :Imprint: Springer,2015. - ix, 319 p. :ill., digital ;24 cm. - Advances in experimental medicine and biology,v.8830065-2598 ;. - Advances in experimental medicine and biology ;780..

Metagenomics as a Tool for Enzyme Discovery: Hydrolytic Enzymes from Marine-related Metagenomes -- Investigating Bacterial Protein Synthesis Using Systems Biology Approaches -- Biology and Assembly of the Bacterial Envelope -- Comparative Genomics and Evolutionary Modularity of Prokaryotes -- Predicting Functional Interactions among Genes in Prokaryotes by Genomic Context -- Functional Implications for Domain Organization within Prokaryotic Rhomboid Proteases -- Mapping Transcription Regulatory Networks with ChIP-seq and RNA-seq -- Quantitative and Systems-Based Approaches for Deciphering Bacterial Membrane Interactome and Gene Function -- Toward Network Biology in E. coli Cell -- Genetic Interaction Scoring Procedure for Bacterial Species -- Mapping the Protein-Protein Interactome Networks Using Yeast Two-Hybrid Screens -- Biogenesis of Escherichia coli DMSO Reductase: A Network of Participants for Protein Folding and Complex Enzyme Maturation -- Microbial Proteome Profiling and Systems Biology: Applications to Mycobacterium tuberculosis -- Structural Aspects of Bacterial Outer Membrane Protein Assembly -- Substrate Interaction Networks of the Escherichia coli Chaperones: Trigger Factor, DnaK and GroEL -- Genetic, Biochemical, and Structural Analyses of Bacterial Surface Polysaccharides.

This book focuses on innovative experimental and computational approaches for charting interaction networks in bacterial species. The first part of the volume consists of nine chapters, focusing on biochemical and genetics and genomics approaches including yeast two hybrid, metagenomics, affinity purification in combination with mass spectrometry, chromatin-immunoprecipitation coupled with sequencing, large-scale synthetic genetic screens, and quantitative-based mass spectrometry strategies for mapping the bacterial physical, functional, substrate, and regulatory interaction networks needed for interpreting biological networks, inferring gene function, enzyme discovery, and identifying new drug targets. The second part comprises five chapters, covering the network of participants for protein folding and complex enzyme maturation. It also covers the structural approaches required to understand bacterial intramembrane proteolysis and the structure and function of bacterial proteins involved in surface polysaccharides, outer membrane, and envelope assembly. This volume concludes with a focus on computational and comparative genomics approaches, especially network-based methods for predicting physical or functional interactions, and integrative analytical approaches for generating more reliable information on bacterial gene function. This book provides foundational knowledge in the understanding of prokaryotic systems biology by illuminating how bacterial genes f unction within the framework of global cellular processes. The book will enable the microbiology community to create substantive resources for addressing many pending unanswered questions, and facilitate the development of new technologies that can be applied to other bacterial species lacking experimental data.

ISBN: 9783319236032

Standard No.: 10.1007/978-3-319-23603-2doiSubjects--Topical Terms:

683756
Systems Biology.

LC Class. No.: QH301 / .P76 2015

Dewey Class. No.: 570

Prokaryotic systems biology
LDR:04157nam a2200337 a 4500 001 838053
003 DE-He213
005 20160413142206.0
006 m d
007 cr nn 008maaau
008 160616s2015 gw s 0 eng d
020 $a 9783319236032 $q (electronic bk.)
020 $a 9783319236025 $q (paper)
024 7 $a 10.1007/978-3-319-23603-2 $2 doi
035 $a 978-3-319-23603-2
040 $a GP $c GP
041 0 $a eng
050 4 $a QH301 $b .P76 2015
072 7 $a PSA $2 bicssc
072 7 $a SCI086000 $2 bisacsh
072 7 $a SCI064000 $2 bisacsh
082 0 4 $a 570 $2 23
090 $a QH301 $b .P964 2015
245 0 0 $a Prokaryotic systems biology $h [electronic resource] / $c edited by Nevan J. Krogan, Mohan Babu.
260 $a Cham : $c 2015. $b Imprint: Springer, $b Springer International Publishing :
300 $a ix, 319 p. : $b ill., digital ; $c 24 cm.
490 1 $a Advances in experimental medicine and biology, $x 0065-2598 ; $v v.883
505 0 $a Metagenomics as a Tool for Enzyme Discovery: Hydrolytic Enzymes from Marine-related Metagenomes -- Investigating Bacterial Protein Synthesis Using Systems Biology Approaches -- Biology and Assembly of the Bacterial Envelope -- Comparative Genomics and Evolutionary Modularity of Prokaryotes -- Predicting Functional Interactions among Genes in Prokaryotes by Genomic Context -- Functional Implications for Domain Organization within Prokaryotic Rhomboid Proteases -- Mapping Transcription Regulatory Networks with ChIP-seq and RNA-seq -- Quantitative and Systems-Based Approaches for Deciphering Bacterial Membrane Interactome and Gene Function -- Toward Network Biology in E. coli Cell -- Genetic Interaction Scoring Procedure for Bacterial Species -- Mapping the Protein-Protein Interactome Networks Using Yeast Two-Hybrid Screens -- Biogenesis of Escherichia coli DMSO Reductase: A Network of Participants for Protein Folding and Complex Enzyme Maturation -- Microbial Proteome Profiling and Systems Biology: Applications to Mycobacterium tuberculosis -- Structural Aspects of Bacterial Outer Membrane Protein Assembly -- Substrate Interaction Networks of the Escherichia coli Chaperones: Trigger Factor, DnaK and GroEL -- Genetic, Biochemical, and Structural Analyses of Bacterial Surface Polysaccharides.
520 $a This book focuses on innovative experimental and computational approaches for charting interaction networks in bacterial species. The first part of the volume consists of nine chapters, focusing on biochemical and genetics and genomics approaches including yeast two hybrid, metagenomics, affinity purification in combination with mass spectrometry, chromatin-immunoprecipitation coupled with sequencing, large-scale synthetic genetic screens, and quantitative-based mass spectrometry strategies for mapping the bacterial physical, functional, substrate, and regulatory interaction networks needed for interpreting biological networks, inferring gene function, enzyme discovery, and identifying new drug targets. The second part comprises five chapters, covering the network of participants for protein folding and complex enzyme maturation. It also covers the structural approaches required to understand bacterial intramembrane proteolysis and the structure and function of bacterial proteins involved in surface polysaccharides, outer membrane, and envelope assembly. This volume concludes with a focus on computational and comparative genomics approaches, especially network-based methods for predicting physical or functional interactions, and integrative analytical approaches for generating more reliable information on bacterial gene function. This book provides foundational knowledge in the understanding of prokaryotic systems biology by illuminating how bacterial genes f unction within the framework of global cellular processes. The book will enable the microbiology community to create substantive resources for addressing many pending unanswered questions, and facilitate the development of new technologies that can be applied to other bacterial species lacking experimental data.
650 2 4 $a Systems Biology. $3 683756
650 1 4 $a Life Sciences. $3 593888
650 0 $a Systems biology. $3 600045
650 0 $a Life sciences. $3 815602
650 0 $a Bacteriology. $3 668505
650 0 $a Proteomics. $3 581930
700 1 $a Babu, Mohan. $3 1068944
700 1 $a Krogan, Nevan J. $3 1068943
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer eBooks
830 0 $a Advances in experimental medicine and biology ; $v 780. $3 881230
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-23603-2
950 $a Biomedical and Life Sciences (Springer-11642)